Relationship between the Patients’ Setup Errors with Dosimetric and Radiobiologic Parameters in Whole Breast Radiotherapy
parameters for left-sided Whole-Breast Irradiation (WBI) in three different radiotherapy techniques, including Intensity-Modulated Radiation Therapy (IMRT), Field-In-Field (FIF), and Conventional Wedge (CW). Materials and Methods: Computed Tomography (CT) images of 10 female patients with early-...
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2023-06-01
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| Series: | Frontiers in Biomedical Technologies |
| Subjects: | |
| Online Access: | https://fbt.tums.ac.ir/index.php/fbt/article/view/489 |
| _version_ | 1797742521615384576 |
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| author | Zahra Alijani Kourosh Ebrahimnejad Gorji Ali Shabestani Monfared Abbas Rahimi Alisaraee Ali Esmaeeli Fatemeh Niksirat |
| author_facet | Zahra Alijani Kourosh Ebrahimnejad Gorji Ali Shabestani Monfared Abbas Rahimi Alisaraee Ali Esmaeeli Fatemeh Niksirat |
| author_sort | Zahra Alijani |
| collection | DOAJ |
| description |
parameters for left-sided Whole-Breast Irradiation (WBI) in three different radiotherapy techniques, including Intensity-Modulated Radiation Therapy (IMRT), Field-In-Field (FIF), and Conventional Wedge (CW).
Materials and Methods: Computed Tomography (CT) images of 10 female patients with early-stage left-sided breast cancer were used to simulate different radiotherapy techniques (IMRT, FIF, and CW). The dosimetric parameters; Conformity Index (CI), Homogeneity Index (HI), the dose received by at least 95% (D95%) of Planning Tumor Volume (PTV), the volume of lung and heart that respectively received at least 20% (V20%) and 40% (V40%) of the prescribed dose, as well as, the radiobiologic parameters, including Tumor Control Probability (TCP) and Normal Tissue Complication Probability (NTCP) were assessed for setup errors in patients. The setup errors were assessed by shifting the isocenters and gantry angles of the treatment plans.
Results: The D95% of the PTV for an isocenter misplacement plan in the posterior direction decreased by 66.99 (IMRT), 71.86 (CW), and 68.25% (FIF). The TCP of the PTV was reduced by 26.66, 39.16, and 36.97% for IMRT, CW, and FIF techniques, respectively. Increasing gantry angle by a ±10 degree caused a 43%, 41%, and 41% decrease in the D95% of IMRT, FIF, and CW techniques, respectively. The TCP values decreased about 18% in all three techniques with a ±10 degree gantry angle shift; however, the NTCP values of the heart and lungs increased for all three methods. The CI and HI values had significantly more changes with increasing setup errors in the IMRT than in the two techniques.
Conclusion: The radiobiologic parameters in IMRT were less sensitive to setup errors compared to FIF and CW techniques. The radiobiological parameters can help estimate the setup errors along with physical parameters during breast radiotherapy.
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| first_indexed | 2024-03-12T14:42:02Z |
| format | Article |
| id | doaj.art-6c522708a53f479caa462737d73ff91e |
| institution | Directory Open Access Journal |
| issn | 2345-5837 |
| language | English |
| last_indexed | 2024-03-12T14:42:02Z |
| publishDate | 2023-06-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Frontiers in Biomedical Technologies |
| spelling | doaj.art-6c522708a53f479caa462737d73ff91e2023-08-16T05:59:27ZengTehran University of Medical SciencesFrontiers in Biomedical Technologies2345-58372023-06-0110310.18502/fbt.v10i3.13155Relationship between the Patients’ Setup Errors with Dosimetric and Radiobiologic Parameters in Whole Breast RadiotherapyZahra Alijani0Kourosh Ebrahimnejad Gorji1Ali Shabestani Monfared2Abbas Rahimi Alisaraee3Ali Esmaeeli4Fatemeh Niksirat5Student Research Committee, Babol University of Medical Sciences, Babol, IranDepartment of Medical Physics Radiobiology and Radiation Protection, School of Medicine, Babol University of Medical Sciences, Babol, IranCancer Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, IranDepartment of Radiotherapy, Guilan University of Medical Sciences, Rasht, IranDepartment of Physics, Islamic Azad University, Rasht, IranDepartment of Medical Physics Radiobiology and Radiation Protection, School of Medicine, Babol University of Medical Sciences, Babol, Iran parameters for left-sided Whole-Breast Irradiation (WBI) in three different radiotherapy techniques, including Intensity-Modulated Radiation Therapy (IMRT), Field-In-Field (FIF), and Conventional Wedge (CW). Materials and Methods: Computed Tomography (CT) images of 10 female patients with early-stage left-sided breast cancer were used to simulate different radiotherapy techniques (IMRT, FIF, and CW). The dosimetric parameters; Conformity Index (CI), Homogeneity Index (HI), the dose received by at least 95% (D95%) of Planning Tumor Volume (PTV), the volume of lung and heart that respectively received at least 20% (V20%) and 40% (V40%) of the prescribed dose, as well as, the radiobiologic parameters, including Tumor Control Probability (TCP) and Normal Tissue Complication Probability (NTCP) were assessed for setup errors in patients. The setup errors were assessed by shifting the isocenters and gantry angles of the treatment plans. Results: The D95% of the PTV for an isocenter misplacement plan in the posterior direction decreased by 66.99 (IMRT), 71.86 (CW), and 68.25% (FIF). The TCP of the PTV was reduced by 26.66, 39.16, and 36.97% for IMRT, CW, and FIF techniques, respectively. Increasing gantry angle by a ±10 degree caused a 43%, 41%, and 41% decrease in the D95% of IMRT, FIF, and CW techniques, respectively. The TCP values decreased about 18% in all three techniques with a ±10 degree gantry angle shift; however, the NTCP values of the heart and lungs increased for all three methods. The CI and HI values had significantly more changes with increasing setup errors in the IMRT than in the two techniques. Conclusion: The radiobiologic parameters in IMRT were less sensitive to setup errors compared to FIF and CW techniques. The radiobiological parameters can help estimate the setup errors along with physical parameters during breast radiotherapy. https://fbt.tums.ac.ir/index.php/fbt/article/view/489Whole Breast RadiotherapySetup ErrorsIntensity-Modulated Radiation TherapyField-In-FieldRadiobiological Parameters |
| spellingShingle | Zahra Alijani Kourosh Ebrahimnejad Gorji Ali Shabestani Monfared Abbas Rahimi Alisaraee Ali Esmaeeli Fatemeh Niksirat Relationship between the Patients’ Setup Errors with Dosimetric and Radiobiologic Parameters in Whole Breast Radiotherapy Frontiers in Biomedical Technologies Whole Breast Radiotherapy Setup Errors Intensity-Modulated Radiation Therapy Field-In-Field Radiobiological Parameters |
| title | Relationship between the Patients’ Setup Errors with Dosimetric and Radiobiologic Parameters in Whole Breast Radiotherapy |
| title_full | Relationship between the Patients’ Setup Errors with Dosimetric and Radiobiologic Parameters in Whole Breast Radiotherapy |
| title_fullStr | Relationship between the Patients’ Setup Errors with Dosimetric and Radiobiologic Parameters in Whole Breast Radiotherapy |
| title_full_unstemmed | Relationship between the Patients’ Setup Errors with Dosimetric and Radiobiologic Parameters in Whole Breast Radiotherapy |
| title_short | Relationship between the Patients’ Setup Errors with Dosimetric and Radiobiologic Parameters in Whole Breast Radiotherapy |
| title_sort | relationship between the patients setup errors with dosimetric and radiobiologic parameters in whole breast radiotherapy |
| topic | Whole Breast Radiotherapy Setup Errors Intensity-Modulated Radiation Therapy Field-In-Field Radiobiological Parameters |
| url | https://fbt.tums.ac.ir/index.php/fbt/article/view/489 |
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