Ganglioside GD3 May Suppress the Functional Activities of Benign Skin T Cells in Cutaneous T-Cell Lymphoma
In cutaneous T-cell lymphoma (CTCL), which arises from skin-tropic memory T cells, malignant T cells and benign T cells are confined in the same skin lesions. It is thus difficult to evaluate the phenotypic characteristics and functional activities of benign T cells in CTCL. Disialoganglioside with...
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Frontiers Media S.A.
2021-03-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2021.651048/full |
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| author | Miki Kume Eiji Kiyohara Yutaka Matsumura Hanako Koguchi-Yoshioka Hanako Koguchi-Yoshioka Atsushi Tanemura Yuma Hanaoka Mifue Taminato Hiroki Tashima Koichi Tomita Tateki Kubo Rei Watanabe Rei Watanabe Manabu Fujimoto |
| author_facet | Miki Kume Eiji Kiyohara Yutaka Matsumura Hanako Koguchi-Yoshioka Hanako Koguchi-Yoshioka Atsushi Tanemura Yuma Hanaoka Mifue Taminato Hiroki Tashima Koichi Tomita Tateki Kubo Rei Watanabe Rei Watanabe Manabu Fujimoto |
| author_sort | Miki Kume |
| collection | DOAJ |
| description | In cutaneous T-cell lymphoma (CTCL), which arises from skin-tropic memory T cells, malignant T cells and benign T cells are confined in the same skin lesions. It is thus difficult to evaluate the phenotypic characteristics and functional activities of benign T cells in CTCL. Disialoganglioside with three glycosyl groups (GD3) is increasingly expressed on the surface of solid malignant tumor cells and takes part in tumor progression and suppression of tumor immunity. However, the role of GD3 in CTCL is not well-understood. In this study, the malignant and benign T cells in CTCL skin lesions were distinguished by flow cytometry and their phenotypic characteristics were compared with those of T cells from control skin specimens. In CTCL skin lesions, the benign T cells included limited resident memory T cells (TRM), which are sessile in skin and known to exert strong antitumor function. The benign T cells showed diminished Th17 property, and the expression of GD3 was high in the malignant T cells. The expression of GD3 in the malignant T cells inversely correlated with IL-17A production from the benign CD4 T cells. GD3 from the malignant T cells was implied to be involved in suppressing the Th17 activity of the benign T cells independent of the regulation of TRM differentiation in CTCL. Revealing the role of GD3 in inhibiting the production of IL-17A in CTCL would aid the understanding of the suppressive mechanism of the antitumor activity by malignant tumor cells. |
| first_indexed | 2024-12-14T19:18:33Z |
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| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-14T19:18:33Z |
| publishDate | 2021-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-6c52559023404adda83e03f5f61128342022-12-21T22:50:26ZengFrontiers Media S.A.Frontiers in Immunology1664-32242021-03-011210.3389/fimmu.2021.651048651048Ganglioside GD3 May Suppress the Functional Activities of Benign Skin T Cells in Cutaneous T-Cell LymphomaMiki Kume0Eiji Kiyohara1Yutaka Matsumura2Hanako Koguchi-Yoshioka3Hanako Koguchi-Yoshioka4Atsushi Tanemura5Yuma Hanaoka6Mifue Taminato7Hiroki Tashima8Koichi Tomita9Tateki Kubo10Rei Watanabe11Rei Watanabe12Manabu Fujimoto13Department of Dermatology, Course of Integrated Medicine, Graduate School of Medicine, Osaka University, Osaka, JapanDepartment of Dermatology, Course of Integrated Medicine, Graduate School of Medicine, Osaka University, Osaka, JapanDepartment of Dermatology, Course of Integrated Medicine, Graduate School of Medicine, Osaka University, Osaka, JapanDepartment of Dermatology, Course of Integrated Medicine, Graduate School of Medicine, Osaka University, Osaka, JapanDepartment of Integrative Medicine for Allergic and Immunological Diseases, Course of Integrated Medicine, Graduate School of Medicine, Osaka University, Osaka, JapanDepartment of Dermatology, Course of Integrated Medicine, Graduate School of Medicine, Osaka University, Osaka, JapanDepartment of Dermatology, Course of Integrated Medicine, Graduate School of Medicine, Osaka University, Osaka, JapanDepartment of Plastic Surgery, Course of Organ Regulation Medicine, Graduate School of Medicine, Osaka University, Osaka, JapanDepartment of Plastic Surgery, Course of Organ Regulation Medicine, Graduate School of Medicine, Osaka University, Osaka, JapanDepartment of Plastic Surgery, Course of Organ Regulation Medicine, Graduate School of Medicine, Osaka University, Osaka, JapanDepartment of Plastic Surgery, Course of Organ Regulation Medicine, Graduate School of Medicine, Osaka University, Osaka, JapanDepartment of Dermatology, Course of Integrated Medicine, Graduate School of Medicine, Osaka University, Osaka, JapanDepartment of Integrative Medicine for Allergic and Immunological Diseases, Course of Integrated Medicine, Graduate School of Medicine, Osaka University, Osaka, JapanDepartment of Dermatology, Course of Integrated Medicine, Graduate School of Medicine, Osaka University, Osaka, JapanIn cutaneous T-cell lymphoma (CTCL), which arises from skin-tropic memory T cells, malignant T cells and benign T cells are confined in the same skin lesions. It is thus difficult to evaluate the phenotypic characteristics and functional activities of benign T cells in CTCL. Disialoganglioside with three glycosyl groups (GD3) is increasingly expressed on the surface of solid malignant tumor cells and takes part in tumor progression and suppression of tumor immunity. However, the role of GD3 in CTCL is not well-understood. In this study, the malignant and benign T cells in CTCL skin lesions were distinguished by flow cytometry and their phenotypic characteristics were compared with those of T cells from control skin specimens. In CTCL skin lesions, the benign T cells included limited resident memory T cells (TRM), which are sessile in skin and known to exert strong antitumor function. The benign T cells showed diminished Th17 property, and the expression of GD3 was high in the malignant T cells. The expression of GD3 in the malignant T cells inversely correlated with IL-17A production from the benign CD4 T cells. GD3 from the malignant T cells was implied to be involved in suppressing the Th17 activity of the benign T cells independent of the regulation of TRM differentiation in CTCL. Revealing the role of GD3 in inhibiting the production of IL-17A in CTCL would aid the understanding of the suppressive mechanism of the antitumor activity by malignant tumor cells.https://www.frontiersin.org/articles/10.3389/fimmu.2021.651048/fullcutaneous T-cell lymphomagangliosideGD3resident memory T cellsantitumor immunity |
| spellingShingle | Miki Kume Eiji Kiyohara Yutaka Matsumura Hanako Koguchi-Yoshioka Hanako Koguchi-Yoshioka Atsushi Tanemura Yuma Hanaoka Mifue Taminato Hiroki Tashima Koichi Tomita Tateki Kubo Rei Watanabe Rei Watanabe Manabu Fujimoto Ganglioside GD3 May Suppress the Functional Activities of Benign Skin T Cells in Cutaneous T-Cell Lymphoma Frontiers in Immunology cutaneous T-cell lymphoma ganglioside GD3 resident memory T cells antitumor immunity |
| title | Ganglioside GD3 May Suppress the Functional Activities of Benign Skin T Cells in Cutaneous T-Cell Lymphoma |
| title_full | Ganglioside GD3 May Suppress the Functional Activities of Benign Skin T Cells in Cutaneous T-Cell Lymphoma |
| title_fullStr | Ganglioside GD3 May Suppress the Functional Activities of Benign Skin T Cells in Cutaneous T-Cell Lymphoma |
| title_full_unstemmed | Ganglioside GD3 May Suppress the Functional Activities of Benign Skin T Cells in Cutaneous T-Cell Lymphoma |
| title_short | Ganglioside GD3 May Suppress the Functional Activities of Benign Skin T Cells in Cutaneous T-Cell Lymphoma |
| title_sort | ganglioside gd3 may suppress the functional activities of benign skin t cells in cutaneous t cell lymphoma |
| topic | cutaneous T-cell lymphoma ganglioside GD3 resident memory T cells antitumor immunity |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2021.651048/full |
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