Usefulness of 18F-Fluorodeoxyglucose Positron Emission Tomography in Diagnosing Polymyalgia Rheumatica and Large-Vessel Vasculitis: A Case-Control Study
Introduction: We aimed to evaluate the utility of FDG-PET/CT in diagnosing polymyalgia rheumatica (PMR) and associated large-vessel vasculitis (LVV). Methods: We analyzed FDG-PET/CT completed between 2015 and 2019 on patients diagnosed with PMR. For comparisons, patients with PMR were matched 1:1 to...
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MDPI AG
2023-04-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/8/2844 |
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| author | Anne Desvages Florent Hives Xavier Deprez Adeline Pierache Hélène Béhal René-Marc Flipo Julien Paccou |
| author_facet | Anne Desvages Florent Hives Xavier Deprez Adeline Pierache Hélène Béhal René-Marc Flipo Julien Paccou |
| author_sort | Anne Desvages |
| collection | DOAJ |
| description | Introduction: We aimed to evaluate the utility of FDG-PET/CT in diagnosing polymyalgia rheumatica (PMR) and associated large-vessel vasculitis (LVV). Methods: We analyzed FDG-PET/CT completed between 2015 and 2019 on patients diagnosed with PMR. For comparisons, patients with PMR were matched 1:1 to controls based on age and gender. FDG-PET/CT had been completed on the controls over the same period. The FDG uptake was scored visually for 17 articular or periarticular sites and 13 vascular sites using a semi-quantitative scoring system (score of 0–3). Results: Eighty-one patients with PMR and eighty-one controls were included (mean age 70.7 (9.8) years; 44.4% women). Significant differences between the PMR and control groups were found at all articular and periarticular sites for the following: (i) the FDG uptake score (<i>p</i> < 0.001 for all locations); (ii) the number of patients per site with significant FDG uptake (score ≥ 2); (iii) the global FDG articular uptake scores (31 [IQR, 21 to 37] versus 6 [IQR, 3 to 10], <i>p</i> < 0.001); and (iv) the number of sites with significant FDG uptake (score ≥ 2) (scores of 0–17) (11 [IQR, 7 to 13] versus 1 [IQR, 0 to 2], <i>p</i> < 0.001). No significant differences in the global FDG vascular uptake scores were found between the patients who were considered isolated PMR and the control groups. Conclusions: The FDG uptake score and the number of sites with significant FDG uptake could be pertinent criteria for the diagnosis of PMR. Unlike others, we did not confirm the presence of vascular involvement in patients with isolated PMR. |
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| spelling | doaj.art-6c52741b907e46ec9016f73cda3657d62023-11-17T19:49:16ZengMDPI AGJournal of Clinical Medicine2077-03832023-04-01128284410.3390/jcm12082844Usefulness of 18F-Fluorodeoxyglucose Positron Emission Tomography in Diagnosing Polymyalgia Rheumatica and Large-Vessel Vasculitis: A Case-Control StudyAnne Desvages0Florent Hives1Xavier Deprez2Adeline Pierache3Hélène Béhal4René-Marc Flipo5Julien Paccou6Department of Rheumatology, Lille University Hospital, University of Lille, CHU Lille, 59000 Lille, FranceDepartment of Nuclear Medicine, Lille University Hospital, University of Lille, CHU Lille, 59000 Lille, FranceDepartment of Rheumatology, Valenciennes Hospital, 59300 Valenciennes, FranceMETRICS: Evaluation des Technologies de Santé et des Pratiques Médicales, University of Lille, CHU Lille, ULR 2694, 59000 Lille, FranceMETRICS: Evaluation des Technologies de Santé et des Pratiques Médicales, University of Lille, CHU Lille, ULR 2694, 59000 Lille, FranceDepartment of Rheumatology, Lille University Hospital, University of Lille, CHU Lille, 59000 Lille, FranceDepartment of Rheumatology, Lille University Hospital, University of Lille, CHU Lille, 59000 Lille, FranceIntroduction: We aimed to evaluate the utility of FDG-PET/CT in diagnosing polymyalgia rheumatica (PMR) and associated large-vessel vasculitis (LVV). Methods: We analyzed FDG-PET/CT completed between 2015 and 2019 on patients diagnosed with PMR. For comparisons, patients with PMR were matched 1:1 to controls based on age and gender. FDG-PET/CT had been completed on the controls over the same period. The FDG uptake was scored visually for 17 articular or periarticular sites and 13 vascular sites using a semi-quantitative scoring system (score of 0–3). Results: Eighty-one patients with PMR and eighty-one controls were included (mean age 70.7 (9.8) years; 44.4% women). Significant differences between the PMR and control groups were found at all articular and periarticular sites for the following: (i) the FDG uptake score (<i>p</i> < 0.001 for all locations); (ii) the number of patients per site with significant FDG uptake (score ≥ 2); (iii) the global FDG articular uptake scores (31 [IQR, 21 to 37] versus 6 [IQR, 3 to 10], <i>p</i> < 0.001); and (iv) the number of sites with significant FDG uptake (score ≥ 2) (scores of 0–17) (11 [IQR, 7 to 13] versus 1 [IQR, 0 to 2], <i>p</i> < 0.001). No significant differences in the global FDG vascular uptake scores were found between the patients who were considered isolated PMR and the control groups. Conclusions: The FDG uptake score and the number of sites with significant FDG uptake could be pertinent criteria for the diagnosis of PMR. Unlike others, we did not confirm the presence of vascular involvement in patients with isolated PMR.https://www.mdpi.com/2077-0383/12/8/2844polymyalgia rheumaticaFDG-PET/CTlarge-vessel vasculitisgiant cell arteritis |
| spellingShingle | Anne Desvages Florent Hives Xavier Deprez Adeline Pierache Hélène Béhal René-Marc Flipo Julien Paccou Usefulness of 18F-Fluorodeoxyglucose Positron Emission Tomography in Diagnosing Polymyalgia Rheumatica and Large-Vessel Vasculitis: A Case-Control Study Journal of Clinical Medicine polymyalgia rheumatica FDG-PET/CT large-vessel vasculitis giant cell arteritis |
| title | Usefulness of 18F-Fluorodeoxyglucose Positron Emission Tomography in Diagnosing Polymyalgia Rheumatica and Large-Vessel Vasculitis: A Case-Control Study |
| title_full | Usefulness of 18F-Fluorodeoxyglucose Positron Emission Tomography in Diagnosing Polymyalgia Rheumatica and Large-Vessel Vasculitis: A Case-Control Study |
| title_fullStr | Usefulness of 18F-Fluorodeoxyglucose Positron Emission Tomography in Diagnosing Polymyalgia Rheumatica and Large-Vessel Vasculitis: A Case-Control Study |
| title_full_unstemmed | Usefulness of 18F-Fluorodeoxyglucose Positron Emission Tomography in Diagnosing Polymyalgia Rheumatica and Large-Vessel Vasculitis: A Case-Control Study |
| title_short | Usefulness of 18F-Fluorodeoxyglucose Positron Emission Tomography in Diagnosing Polymyalgia Rheumatica and Large-Vessel Vasculitis: A Case-Control Study |
| title_sort | usefulness of 18f fluorodeoxyglucose positron emission tomography in diagnosing polymyalgia rheumatica and large vessel vasculitis a case control study |
| topic | polymyalgia rheumatica FDG-PET/CT large-vessel vasculitis giant cell arteritis |
| url | https://www.mdpi.com/2077-0383/12/8/2844 |
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