Characterization of the Menin-MLL Interaction as Therapeutic Cancer Target

Characterization of the Menin-MLL Interaction as Therapeutic Cancer Target

Inhibiting the interaction of menin with the histone methyltransferase MLL1 (KMT2A) has recently emerged as a novel therapeutic strategy. Beneficial therapeutic effects have been postulated in leukemia, prostate, breast, liver and in synovial sarcoma models. In those indications, MLL1 recruitment by...

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Bibliographic Details
Main Authors: Krzysztof Brzezinka, Ekaterina Nevedomskaya, Ralf Lesche, Andrea Haegebarth, Antonius ter Laak, Amaury E. Fernández-Montalván, Uwe Eberspaecher, Nicolas D. Werbeck, Ursula Moenning, Stephan Siegel, Bernard Haendler, Ashley L. Eheim, Carlo Stresemann
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:Cancers
Subjects:
chemical probe
menin-mll
target validation
cancer
solid tumor
Online Access:https://www.mdpi.com/2072-6694/12/1/201

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