Coordination of RNA Processing Regulation by Signal Transduction Pathways
Signal transduction pathways transmit the information received from external and internal cues and generate a response that allows the cell to adapt to changes in the surrounding environment. Signaling pathways trigger rapid responses by changing the activity or localization of existing molecules, a...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-10-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/11/10/1475 |
| _version_ | 1797515221558886400 |
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| author | Veronica Ruta Vittoria Pagliarini Claudio Sette |
| author_facet | Veronica Ruta Vittoria Pagliarini Claudio Sette |
| author_sort | Veronica Ruta |
| collection | DOAJ |
| description | Signal transduction pathways transmit the information received from external and internal cues and generate a response that allows the cell to adapt to changes in the surrounding environment. Signaling pathways trigger rapid responses by changing the activity or localization of existing molecules, as well as long-term responses that require the activation of gene expression programs. All steps involved in the regulation of gene expression, from transcription to processing and utilization of new transcripts, are modulated by multiple signal transduction pathways. This review provides a broad overview of the post-translational regulation of factors involved in RNA processing events by signal transduction pathways, with particular focus on the regulation of pre-mRNA splicing, cleavage and polyadenylation. The effects of several post-translational modifications (i.e., sumoylation, ubiquitination, methylation, acetylation and phosphorylation) on the expression, subcellular localization, stability and affinity for RNA and protein partners of many RNA-binding proteins are highlighted. Moreover, examples of how some of the most common signal transduction pathways can modulate biological processes through changes in RNA processing regulation are illustrated. Lastly, we discuss challenges and opportunities of therapeutic approaches that correct RNA processing defects and target signaling molecules. |
| first_indexed | 2024-03-10T06:42:27Z |
| format | Article |
| id | doaj.art-6c54b0ae397c4b9bb27b3c83e25651b7 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-10T06:42:27Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-6c54b0ae397c4b9bb27b3c83e25651b72023-11-22T17:34:09ZengMDPI AGBiomolecules2218-273X2021-10-011110147510.3390/biom11101475Coordination of RNA Processing Regulation by Signal Transduction PathwaysVeronica Ruta0Vittoria Pagliarini1Claudio Sette2Department of Neuroscience, Section of Human Anatomy, Catholic University of the Sacred Heart, 00168 Rome, ItalyDepartment of Neuroscience, Section of Human Anatomy, Catholic University of the Sacred Heart, 00168 Rome, ItalyDepartment of Neuroscience, Section of Human Anatomy, Catholic University of the Sacred Heart, 00168 Rome, ItalySignal transduction pathways transmit the information received from external and internal cues and generate a response that allows the cell to adapt to changes in the surrounding environment. Signaling pathways trigger rapid responses by changing the activity or localization of existing molecules, as well as long-term responses that require the activation of gene expression programs. All steps involved in the regulation of gene expression, from transcription to processing and utilization of new transcripts, are modulated by multiple signal transduction pathways. This review provides a broad overview of the post-translational regulation of factors involved in RNA processing events by signal transduction pathways, with particular focus on the regulation of pre-mRNA splicing, cleavage and polyadenylation. The effects of several post-translational modifications (i.e., sumoylation, ubiquitination, methylation, acetylation and phosphorylation) on the expression, subcellular localization, stability and affinity for RNA and protein partners of many RNA-binding proteins are highlighted. Moreover, examples of how some of the most common signal transduction pathways can modulate biological processes through changes in RNA processing regulation are illustrated. Lastly, we discuss challenges and opportunities of therapeutic approaches that correct RNA processing defects and target signaling molecules.https://www.mdpi.com/2218-273X/11/10/1475signal transductionalternative splicingalternative polyadenylationstress response |
| spellingShingle | Veronica Ruta Vittoria Pagliarini Claudio Sette Coordination of RNA Processing Regulation by Signal Transduction Pathways Biomolecules signal transduction alternative splicing alternative polyadenylation stress response |
| title | Coordination of RNA Processing Regulation by Signal Transduction Pathways |
| title_full | Coordination of RNA Processing Regulation by Signal Transduction Pathways |
| title_fullStr | Coordination of RNA Processing Regulation by Signal Transduction Pathways |
| title_full_unstemmed | Coordination of RNA Processing Regulation by Signal Transduction Pathways |
| title_short | Coordination of RNA Processing Regulation by Signal Transduction Pathways |
| title_sort | coordination of rna processing regulation by signal transduction pathways |
| topic | signal transduction alternative splicing alternative polyadenylation stress response |
| url | https://www.mdpi.com/2218-273X/11/10/1475 |
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