Brain perfusion impairment in neurologically asymptomatic adult patients with Sickle-Cell Disease shown by voxel-based analysis of SPECT images
Cerebrovascular lesions are frequently observed in patients with sickle cell disease (SCD) and these structural lesions are preceded by insidious perfusion deficits. Our aim was to investigate the presence of brain perfusion deficits in neurologically asymptomatic SCD patients, especially affecting...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2013-12-01
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| Series: | Frontiers in Neurology |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fneur.2013.00207/full |
| _version_ | 1818505519240839168 |
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| author | Leonardo eDeus-Silva Leonardo eBonilha Benito Pereira Damasceno Andre Luiz Costa Clarissa Lin Yasuda Fernando Ferreira Costa Allan Oliveira Santos Elba eEtchebehere Regis eOquendo-Nogueira Renata eFockink Claudio Fróes de Freitas Edwaldo Eduardo Camargo Li Li Min Fernando eCendes Sara Ollala Saad |
| author_facet | Leonardo eDeus-Silva Leonardo eBonilha Benito Pereira Damasceno Andre Luiz Costa Clarissa Lin Yasuda Fernando Ferreira Costa Allan Oliveira Santos Elba eEtchebehere Regis eOquendo-Nogueira Renata eFockink Claudio Fróes de Freitas Edwaldo Eduardo Camargo Li Li Min Fernando eCendes Sara Ollala Saad |
| author_sort | Leonardo eDeus-Silva |
| collection | DOAJ |
| description | Cerebrovascular lesions are frequently observed in patients with sickle cell disease (SCD) and these structural lesions are preceded by insidious perfusion deficits. Our aim was to investigate the presence of brain perfusion deficits in neurologically asymptomatic SCD patients, especially affecting microvessels. For this study, forty-two SCD patients (33 sickle cell anemia (HbSS), 6 sickle hemoglobin C disease (HbSC) and 3 sickle β-thalassemia disease (HbSβ) with mean hematocrit of 25.1 (±4.85; 15.6-38.5) underwent brain perfusion SPECT using the tracer 99mTc-ECD. Images from SCD patients were compared to images of a healthy control group (29 females and 20 males, mean age 31 ±8; range 25-49 years). Images underwent voxel-wise comparison of regional tracer uptake using paired t-test to estimate the probability of each voxel to have an increased or decreased tracer uptake. When compared to controls, SCD patients exhibited significantly reduced tracer uptake in basal ganglia and thalami, the anterior frontal region and the watershed region of the temporo-parietal-occipital transition. (p<0.05). Our study showed that neurologically asymptomatic adult SCD patients exhibit a pattern of reduced 99mTc-ECD tracer uptake demonstrated by SPECT. Early diagnosis of this cerebral vasculopathy has prognostic implications and can be determinant in considering therapeutic alternatives to avoid increasing brain lesion load and progressive disability. |
| first_indexed | 2024-12-10T21:51:53Z |
| format | Article |
| id | doaj.art-6c5593151609480ca0d67a931371dfe7 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-10T21:51:53Z |
| publishDate | 2013-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-6c5593151609480ca0d67a931371dfe72022-12-22T01:32:10ZengFrontiers Media S.A.Frontiers in Neurology1664-22952013-12-01410.3389/fneur.2013.0020767317Brain perfusion impairment in neurologically asymptomatic adult patients with Sickle-Cell Disease shown by voxel-based analysis of SPECT imagesLeonardo eDeus-Silva0Leonardo eBonilha1Benito Pereira Damasceno2Andre Luiz Costa3Clarissa Lin Yasuda4Fernando Ferreira Costa5Allan Oliveira Santos6Elba eEtchebehere7Regis eOquendo-Nogueira8Renata eFockink9Claudio Fróes de Freitas10Edwaldo Eduardo Camargo11Li Li Min12Fernando eCendes13Sara Ollala Saad14UNICAMPMedical University of South CarolinaUNICAMPUniversity of City of São Paulo (UNICID)UNICAMPUNICAMPUNICAMPUNICAMPUNICAMPUNICAMPUniversity of City of São Paulo (UNICID)UNICAMPUNICAMPUNICAMPUNICAMPCerebrovascular lesions are frequently observed in patients with sickle cell disease (SCD) and these structural lesions are preceded by insidious perfusion deficits. Our aim was to investigate the presence of brain perfusion deficits in neurologically asymptomatic SCD patients, especially affecting microvessels. For this study, forty-two SCD patients (33 sickle cell anemia (HbSS), 6 sickle hemoglobin C disease (HbSC) and 3 sickle β-thalassemia disease (HbSβ) with mean hematocrit of 25.1 (±4.85; 15.6-38.5) underwent brain perfusion SPECT using the tracer 99mTc-ECD. Images from SCD patients were compared to images of a healthy control group (29 females and 20 males, mean age 31 ±8; range 25-49 years). Images underwent voxel-wise comparison of regional tracer uptake using paired t-test to estimate the probability of each voxel to have an increased or decreased tracer uptake. When compared to controls, SCD patients exhibited significantly reduced tracer uptake in basal ganglia and thalami, the anterior frontal region and the watershed region of the temporo-parietal-occipital transition. (p<0.05). Our study showed that neurologically asymptomatic adult SCD patients exhibit a pattern of reduced 99mTc-ECD tracer uptake demonstrated by SPECT. Early diagnosis of this cerebral vasculopathy has prognostic implications and can be determinant in considering therapeutic alternatives to avoid increasing brain lesion load and progressive disability.http://journal.frontiersin.org/Journal/10.3389/fneur.2013.00207/fullImage Processing, Computer-AssistedBrain PerfusionSickle Cell DiseaseSPECTvoxel based analysis. |
| spellingShingle | Leonardo eDeus-Silva Leonardo eBonilha Benito Pereira Damasceno Andre Luiz Costa Clarissa Lin Yasuda Fernando Ferreira Costa Allan Oliveira Santos Elba eEtchebehere Regis eOquendo-Nogueira Renata eFockink Claudio Fróes de Freitas Edwaldo Eduardo Camargo Li Li Min Fernando eCendes Sara Ollala Saad Brain perfusion impairment in neurologically asymptomatic adult patients with Sickle-Cell Disease shown by voxel-based analysis of SPECT images Frontiers in Neurology Image Processing, Computer-Assisted Brain Perfusion Sickle Cell Disease SPECT voxel based analysis. |
| title | Brain perfusion impairment in neurologically asymptomatic adult patients with Sickle-Cell Disease shown by voxel-based analysis of SPECT images |
| title_full | Brain perfusion impairment in neurologically asymptomatic adult patients with Sickle-Cell Disease shown by voxel-based analysis of SPECT images |
| title_fullStr | Brain perfusion impairment in neurologically asymptomatic adult patients with Sickle-Cell Disease shown by voxel-based analysis of SPECT images |
| title_full_unstemmed | Brain perfusion impairment in neurologically asymptomatic adult patients with Sickle-Cell Disease shown by voxel-based analysis of SPECT images |
| title_short | Brain perfusion impairment in neurologically asymptomatic adult patients with Sickle-Cell Disease shown by voxel-based analysis of SPECT images |
| title_sort | brain perfusion impairment in neurologically asymptomatic adult patients with sickle cell disease shown by voxel based analysis of spect images |
| topic | Image Processing, Computer-Assisted Brain Perfusion Sickle Cell Disease SPECT voxel based analysis. |
| url | http://journal.frontiersin.org/Journal/10.3389/fneur.2013.00207/full |
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