Potential oxidative stress related targets of mitochondria-focused therapy of PTSD
Post-traumatic stress disorder (PTSD) remains a highly prevalent, under-diagnosed, and under-treated psychiatric disorder that often deteriorates over time, and is highly comorbid with major depressive disorder, suicidality, and substance use disorder. Several biomarkers have been proposed but have...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-11-01
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| Series: | Frontiers in Physiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2023.1266575/full |
| _version_ | 1797628992628457472 |
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| author | Hanna Kmita Graziano Pinna Graziano Pinna Graziano Pinna Volodymyr I. Lushchak Volodymyr I. Lushchak |
| author_facet | Hanna Kmita Graziano Pinna Graziano Pinna Graziano Pinna Volodymyr I. Lushchak Volodymyr I. Lushchak |
| author_sort | Hanna Kmita |
| collection | DOAJ |
| description | Post-traumatic stress disorder (PTSD) remains a highly prevalent, under-diagnosed, and under-treated psychiatric disorder that often deteriorates over time, and is highly comorbid with major depressive disorder, suicidality, and substance use disorder. Several biomarkers have been proposed but have yet to be implemented into clinical practice. Treatments, including selective serotonin reuptake inhibitors, are efficacious in only a small number of patients, which underscores the need to develop novel, efficient treatments. Mitochondrial dysfunction resulting from chronic oxidative stress has been linked with both altered neurotransmitter signaling and the inflammatory response. Hereinafter, we discuss mechanisms by which mitochondrial dysfunction may contribute to the development of PTSD symptoms, and how these may even increase PTSD susceptibility. We also highlight possible therapeutic targets to reduce oxidative stress to prevent or treat PTSD symptoms. |
| first_indexed | 2024-03-11T10:46:58Z |
| format | Article |
| id | doaj.art-6c5b78487d5742a7839060c1bee2dcfe |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-03-11T10:46:58Z |
| publishDate | 2023-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-6c5b78487d5742a7839060c1bee2dcfe2023-11-14T02:03:39ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2023-11-011410.3389/fphys.2023.12665751266575Potential oxidative stress related targets of mitochondria-focused therapy of PTSDHanna Kmita0Graziano Pinna1Graziano Pinna2Graziano Pinna3Volodymyr I. Lushchak4Volodymyr I. Lushchak5Department of Bioenergetics, Institute of Molecular Biology and Biotechnology, Faculty of Biology, Adam Mickiewicz University, Poznań, PolandPsychiatric Institute (SPHPI), Chicago, IL, United StatesUI Center on Depression and Resilience (UICDR), Chicago, IL, United StatesCenter for Alcohol Research in Epigenetics (CARE), Department of Psychiatry, College of Medicine, University of Illinois at Chicago, Chicago, IL, United StatesDepartment of Biochemistry and Biotechnology, Vasyl Stefanyk Precarpathian National University, Ivano-Frankivsk, UkraineResearch and Development University, Ivano-Frankivsk, UkrainePost-traumatic stress disorder (PTSD) remains a highly prevalent, under-diagnosed, and under-treated psychiatric disorder that often deteriorates over time, and is highly comorbid with major depressive disorder, suicidality, and substance use disorder. Several biomarkers have been proposed but have yet to be implemented into clinical practice. Treatments, including selective serotonin reuptake inhibitors, are efficacious in only a small number of patients, which underscores the need to develop novel, efficient treatments. Mitochondrial dysfunction resulting from chronic oxidative stress has been linked with both altered neurotransmitter signaling and the inflammatory response. Hereinafter, we discuss mechanisms by which mitochondrial dysfunction may contribute to the development of PTSD symptoms, and how these may even increase PTSD susceptibility. We also highlight possible therapeutic targets to reduce oxidative stress to prevent or treat PTSD symptoms.https://www.frontiersin.org/articles/10.3389/fphys.2023.1266575/fullPTSDmitochondriareactive oxygen speciesmonoamine oxidasemitochondria-derived peptidesmitochondria-derived vesicles |
| spellingShingle | Hanna Kmita Graziano Pinna Graziano Pinna Graziano Pinna Volodymyr I. Lushchak Volodymyr I. Lushchak Potential oxidative stress related targets of mitochondria-focused therapy of PTSD Frontiers in Physiology PTSD mitochondria reactive oxygen species monoamine oxidase mitochondria-derived peptides mitochondria-derived vesicles |
| title | Potential oxidative stress related targets of mitochondria-focused therapy of PTSD |
| title_full | Potential oxidative stress related targets of mitochondria-focused therapy of PTSD |
| title_fullStr | Potential oxidative stress related targets of mitochondria-focused therapy of PTSD |
| title_full_unstemmed | Potential oxidative stress related targets of mitochondria-focused therapy of PTSD |
| title_short | Potential oxidative stress related targets of mitochondria-focused therapy of PTSD |
| title_sort | potential oxidative stress related targets of mitochondria focused therapy of ptsd |
| topic | PTSD mitochondria reactive oxygen species monoamine oxidase mitochondria-derived peptides mitochondria-derived vesicles |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2023.1266575/full |
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