An overview of PAX1: Expression, function and regulation in development and diseases
Transcription factors play multifaceted roles in embryonic development and diseases. PAX1, a paired-box transcription factor, has been elucidated to play key roles in multiple tissues during embryonic development by extensive studies. Recently, an emerging role of PAX1 in cancers was clarified. Here...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2022.1051102/full |
| _version_ | 1811197362363695104 |
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| author | Weiyin Wu Xiangjun Kong Yanhan Jia Yihui Jia Weimei Ou Cuilian Dai Gang Li Rui Gao |
| author_facet | Weiyin Wu Xiangjun Kong Yanhan Jia Yihui Jia Weimei Ou Cuilian Dai Gang Li Rui Gao |
| author_sort | Weiyin Wu |
| collection | DOAJ |
| description | Transcription factors play multifaceted roles in embryonic development and diseases. PAX1, a paired-box transcription factor, has been elucidated to play key roles in multiple tissues during embryonic development by extensive studies. Recently, an emerging role of PAX1 in cancers was clarified. Herein, we summarize the expression and functions of PAX1 in skeletal system and thymus development, as well as cancer biology and outline its cellular and molecular modes of action and the association of PAX1 mutation or dysregulation with human diseases, thus providing insights for the molecular basis of congenital diseases and cancers. |
| first_indexed | 2024-04-12T01:13:25Z |
| format | Article |
| id | doaj.art-6c5c196397a8440a9aad181d41f4698c |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-04-12T01:13:25Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-6c5c196397a8440a9aad181d41f4698c2022-12-22T03:54:03ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2022-10-011010.3389/fcell.2022.10511021051102An overview of PAX1: Expression, function and regulation in development and diseasesWeiyin Wu0Xiangjun Kong1Yanhan Jia2Yihui Jia3Weimei Ou4Cuilian Dai5Gang Li6Rui Gao7Institute of Cardiovascular Diseases, Xiamen Cardiovascular Hospital, School of medicine, Xiamen University, Xiamen, ChinaDepartment of Pharmacy, Xiang'an Hospital of Xiamen University, School of medicine, Xiamen University, Xiamen, ChinaSichuan Cancer Hospital and Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, ChinaInstitute of Cardiovascular Diseases, Xiamen Cardiovascular Hospital, School of medicine, Xiamen University, Xiamen, ChinaInstitute of Cardiovascular Diseases, Xiamen Cardiovascular Hospital, School of medicine, Xiamen University, Xiamen, ChinaInstitute of Cardiovascular Diseases, Xiamen Cardiovascular Hospital, School of medicine, Xiamen University, Xiamen, ChinaInstitute of Cardiovascular Diseases, Xiamen Cardiovascular Hospital, School of medicine, Xiamen University, Xiamen, ChinaInstitute of Cardiovascular Diseases, Xiamen Cardiovascular Hospital, School of medicine, Xiamen University, Xiamen, ChinaTranscription factors play multifaceted roles in embryonic development and diseases. PAX1, a paired-box transcription factor, has been elucidated to play key roles in multiple tissues during embryonic development by extensive studies. Recently, an emerging role of PAX1 in cancers was clarified. Herein, we summarize the expression and functions of PAX1 in skeletal system and thymus development, as well as cancer biology and outline its cellular and molecular modes of action and the association of PAX1 mutation or dysregulation with human diseases, thus providing insights for the molecular basis of congenital diseases and cancers.https://www.frontiersin.org/articles/10.3389/fcell.2022.1051102/fullPax1transcription factorembryonic developmentdiseasescancer |
| spellingShingle | Weiyin Wu Xiangjun Kong Yanhan Jia Yihui Jia Weimei Ou Cuilian Dai Gang Li Rui Gao An overview of PAX1: Expression, function and regulation in development and diseases Frontiers in Cell and Developmental Biology Pax1 transcription factor embryonic development diseases cancer |
| title | An overview of PAX1: Expression, function and regulation in development and diseases |
| title_full | An overview of PAX1: Expression, function and regulation in development and diseases |
| title_fullStr | An overview of PAX1: Expression, function and regulation in development and diseases |
| title_full_unstemmed | An overview of PAX1: Expression, function and regulation in development and diseases |
| title_short | An overview of PAX1: Expression, function and regulation in development and diseases |
| title_sort | overview of pax1 expression function and regulation in development and diseases |
| topic | Pax1 transcription factor embryonic development diseases cancer |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2022.1051102/full |
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