Gene expression in early and progression phases of autosomal dominant polycystic kidney disease
<p>Abstract</p> <p>Background</p> <p>Little is known about the genes involved in the initial cyst formation and disease progression in autosomal dominant polycystic kidney disease (ADPKD); however, such knowledge is necessary to explore therapeutic avenues for this comm...
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| Format: | Article |
| Language: | English |
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BMC
2008-12-01
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| Series: | BMC Research Notes |
| Online Access: | http://www.biomedcentral.com/1756-0500/1/131 |
| _version_ | 1818661924251893760 |
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| author | Tzeng Yi-Shiuan Chen Wen-Cheng Li Hung |
| author_facet | Tzeng Yi-Shiuan Chen Wen-Cheng Li Hung |
| author_sort | Tzeng Yi-Shiuan |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Little is known about the genes involved in the initial cyst formation and disease progression in autosomal dominant polycystic kidney disease (ADPKD); however, such knowledge is necessary to explore therapeutic avenues for this common inherited kidney disease.</p> <p>Findings</p> <p>To uncover the genetic determinants and molecular mechanisms of ADPKD, we analyzed 4-point time-series DNA microarrays from <it>Pkd1</it><sup><it>L</it>3/<it>L</it>3 </sup>mice to generate high resolution gene expression profiles at different stages of disease progression. We found different characteristic gene expression signatures in the kidneys of <it>Pkd1</it><sup><it>L</it>3/<it>L</it>3 </sup>mice compared to age-matched controls during the initial phase of the disease. By postnatal week 1, the <it>Pkd1</it><sup><it>L</it>3/<it>L</it>3 </sup>kidney already had a distinctive gene expression pattern different from the corresponding normal controls.</p> <p>Conclusion</p> <p>The genes differentially expressed, either induced or repressed, in ADPKD are important in immune defense, cell structure and motility, cellular proliferation, apoptosis and metabolic processes, and include members of three pathways (Wnt, Notch, and BMP) involved in morphogenetic signaling. Further analysis of the gene expression profiles from the early stage of cystogenesis to end stage disease identified a possible gene network involved in the pathogenesis of ADPKD.</p> |
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| format | Article |
| id | doaj.art-6c5c5fd7ec1f4cca88a35f2ed249585b |
| institution | Directory Open Access Journal |
| issn | 1756-0500 |
| language | English |
| last_indexed | 2024-12-17T04:52:47Z |
| publishDate | 2008-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Research Notes |
| spelling | doaj.art-6c5c5fd7ec1f4cca88a35f2ed249585b2022-12-21T22:02:51ZengBMCBMC Research Notes1756-05002008-12-011113110.1186/1756-0500-1-131Gene expression in early and progression phases of autosomal dominant polycystic kidney diseaseTzeng Yi-ShiuanChen Wen-ChengLi Hung<p>Abstract</p> <p>Background</p> <p>Little is known about the genes involved in the initial cyst formation and disease progression in autosomal dominant polycystic kidney disease (ADPKD); however, such knowledge is necessary to explore therapeutic avenues for this common inherited kidney disease.</p> <p>Findings</p> <p>To uncover the genetic determinants and molecular mechanisms of ADPKD, we analyzed 4-point time-series DNA microarrays from <it>Pkd1</it><sup><it>L</it>3/<it>L</it>3 </sup>mice to generate high resolution gene expression profiles at different stages of disease progression. We found different characteristic gene expression signatures in the kidneys of <it>Pkd1</it><sup><it>L</it>3/<it>L</it>3 </sup>mice compared to age-matched controls during the initial phase of the disease. By postnatal week 1, the <it>Pkd1</it><sup><it>L</it>3/<it>L</it>3 </sup>kidney already had a distinctive gene expression pattern different from the corresponding normal controls.</p> <p>Conclusion</p> <p>The genes differentially expressed, either induced or repressed, in ADPKD are important in immune defense, cell structure and motility, cellular proliferation, apoptosis and metabolic processes, and include members of three pathways (Wnt, Notch, and BMP) involved in morphogenetic signaling. Further analysis of the gene expression profiles from the early stage of cystogenesis to end stage disease identified a possible gene network involved in the pathogenesis of ADPKD.</p>http://www.biomedcentral.com/1756-0500/1/131 |
| spellingShingle | Tzeng Yi-Shiuan Chen Wen-Cheng Li Hung Gene expression in early and progression phases of autosomal dominant polycystic kidney disease BMC Research Notes |
| title | Gene expression in early and progression phases of autosomal dominant polycystic kidney disease |
| title_full | Gene expression in early and progression phases of autosomal dominant polycystic kidney disease |
| title_fullStr | Gene expression in early and progression phases of autosomal dominant polycystic kidney disease |
| title_full_unstemmed | Gene expression in early and progression phases of autosomal dominant polycystic kidney disease |
| title_short | Gene expression in early and progression phases of autosomal dominant polycystic kidney disease |
| title_sort | gene expression in early and progression phases of autosomal dominant polycystic kidney disease |
| url | http://www.biomedcentral.com/1756-0500/1/131 |
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