The study evaluating the effect of probiotic supplementation on the mental status, inflammation, and intestinal barrier in major depressive disorder patients using gluten-free or gluten-containing diet (SANGUT study): a 12-week, randomized, double-blind, and placebo-controlled clinical study protocol

The study evaluating the effect of probiotic supplementation on the mental status, inflammation, and intestinal barrier in major depressive disorder patients using gluten-free or gluten-containing diet (SANGUT study): a 12-week, randomized, double-blind, and placebo-controlled clinical study protocol

Abstract Background Current treatment of major depressive disorder (MDD) often does not achieve full remission of symptoms. Therefore, new forms of treatment and/or adjunct therapy are needed. Evidence has confirmed the modulation of the gut–brain–microbiota axis as a promising approach in MDD patie...

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Bibliographic Details
Main Authors: Hanna Karakula-Juchnowicz, Joanna Rog, Dariusz Juchnowicz, Igor Łoniewski, Karolina Skonieczna-Żydecka, Paweł Krukow, Malgorzata Futyma-Jedrzejewska, Mariusz Kaczmarczyk
Format: Article
Language:English
Published: BMC 2019-08-01
Series:Nutrition Journal
Subjects:
Depression
Probiotics
Gluten-free diet
Inflammation
Intervention study
Gut-brain axis
Online Access:http://link.springer.com/article/10.1186/s12937-019-0475-x

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