Malignancies in adult patients with common variable immunodeficiency
Background: Common variable immunodeficiency (CVID) implies an increased risk of cancer, with an estimated incidence of 11-13%, particularly during the 5th and 6th decade of life. B cell-Hodgkin lymphomas are the more frequent cancer, followed by non-Hodgkin lymphoma and epithelial tumors (gastric,...
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| Format: | Article |
| Language: | English |
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Colegio Mexicano de Inmunología Clínica y Alergia, A.C.
2015-03-01
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| Series: | Revista Alergia México |
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| Online Access: | http://revistaalergia.mx/ojs/index.php/ram/article/view/56 |
| _version_ | 1797709811084689408 |
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| author | Eunice Giselle López-Rocha Karen Alicia Rodríguez-Mireles Nora Hilda Segura-Méndez Marco Antonio Yamazaki-Nakashimada |
| author_facet | Eunice Giselle López-Rocha Karen Alicia Rodríguez-Mireles Nora Hilda Segura-Méndez Marco Antonio Yamazaki-Nakashimada |
| author_sort | Eunice Giselle López-Rocha |
| collection | DOAJ |
| description | Background: Common variable immunodeficiency (CVID) implies an increased risk of cancer, with an estimated incidence of 11-13%, particularly during the 5th and 6th decade of life. B cell-Hodgkin lymphomas are the more frequent cancer, followed by non-Hodgkin lymphoma and epithelial tumors (gastric, breast, bladder and cervix).
Objective: To describe the types of cancers in a cohort of adult patients with CVID.
Material and method: An observational, cross-sectional and descriptive study was made in which we reviewed the charts of patients with CVID attending the Primary Immunodeficiencies Clinic at Specialties Hospital Dr. Bernardo Sepulveda, Centro Medico Nacional Siglo XXI, Mexico City.
Results: There were included 23 patients with CVID diagnosis, 13 women (56%) and 10 men (44%), with an average age of 36.7 years. Four patients developed malignancies (2 men and 2 women), with a prevalence of 17.3%. The types of cancers in this group of patients were: B cell-Hodgkin lymphoma (1/23), neuroendocrine carcinoma of the pancreas (1/23), myeloid chronic leukemia (1/23) and thyroid papillary carcinoma (1/23). In two of the subjects the diagnosis of cancer was established previous to CVID diagnosis. The average age of diagnosis of cancer was 27 years (19-34 years).
Conclusions: In our patients we found different types of malignancies compared to previously described. We consider necessary a screening protocol for an early diagnosis of cancer in these patients. The frequency of cancer in our population was the same as reported in the literature. |
| first_indexed | 2024-03-12T06:43:16Z |
| format | Article |
| id | doaj.art-6c5e8a9919d94f9b9b84f4b536b0cca9 |
| institution | Directory Open Access Journal |
| issn | 0002-5151 2448-9190 |
| language | English |
| last_indexed | 2024-03-12T06:43:16Z |
| publishDate | 2015-03-01 |
| publisher | Colegio Mexicano de Inmunología Clínica y Alergia, A.C. |
| record_format | Article |
| series | Revista Alergia México |
| spelling | doaj.art-6c5e8a9919d94f9b9b84f4b536b0cca92023-09-03T00:50:15ZengColegio Mexicano de Inmunología Clínica y Alergia, A.C.Revista Alergia México0002-51512448-91902015-03-01621222710.29262/ram.v62i1.5665Malignancies in adult patients with common variable immunodeficiencyEunice Giselle López-Rocha0Karen Alicia Rodríguez-Mireles1Nora Hilda Segura-Méndez2Marco Antonio Yamazaki-Nakashimada3Instituto Mexicano del Seguro Social, Centro Médico Nacional Siglo XXI, Hospital de Especialidades, Servicio de Alergia e Inmunología Clínica, Ciudad de MéxicoInstituto Mexicano del Seguro Social, Centro Médico Nacional Siglo XXI, Hospital de Especialidades, Servicio de Alergia e Inmunología Clínica, Ciudad de MéxicoInstituto Mexicano del Seguro Social, Centro Médico Nacional Siglo XXI, Hospital de Especialidades, Servicio de Alergia e Inmunología Clínica, Ciudad de MéxicoSecretaría de Salud, Instituto Nacional de Pediatría, Servicio de Inmunología, Ciudad de MéxicoBackground: Common variable immunodeficiency (CVID) implies an increased risk of cancer, with an estimated incidence of 11-13%, particularly during the 5th and 6th decade of life. B cell-Hodgkin lymphomas are the more frequent cancer, followed by non-Hodgkin lymphoma and epithelial tumors (gastric, breast, bladder and cervix). Objective: To describe the types of cancers in a cohort of adult patients with CVID. Material and method: An observational, cross-sectional and descriptive study was made in which we reviewed the charts of patients with CVID attending the Primary Immunodeficiencies Clinic at Specialties Hospital Dr. Bernardo Sepulveda, Centro Medico Nacional Siglo XXI, Mexico City. Results: There were included 23 patients with CVID diagnosis, 13 women (56%) and 10 men (44%), with an average age of 36.7 years. Four patients developed malignancies (2 men and 2 women), with a prevalence of 17.3%. The types of cancers in this group of patients were: B cell-Hodgkin lymphoma (1/23), neuroendocrine carcinoma of the pancreas (1/23), myeloid chronic leukemia (1/23) and thyroid papillary carcinoma (1/23). In two of the subjects the diagnosis of cancer was established previous to CVID diagnosis. The average age of diagnosis of cancer was 27 years (19-34 years). Conclusions: In our patients we found different types of malignancies compared to previously described. We consider necessary a screening protocol for an early diagnosis of cancer in these patients. The frequency of cancer in our population was the same as reported in the literature.http://revistaalergia.mx/ojs/index.php/ram/article/view/56inmunodeficiencia común variablelinfomaneoplasiacáncer |
| spellingShingle | Eunice Giselle López-Rocha Karen Alicia Rodríguez-Mireles Nora Hilda Segura-Méndez Marco Antonio Yamazaki-Nakashimada Malignancies in adult patients with common variable immunodeficiency Revista Alergia México inmunodeficiencia común variable linfoma neoplasia cáncer |
| title | Malignancies in adult patients with common variable immunodeficiency |
| title_full | Malignancies in adult patients with common variable immunodeficiency |
| title_fullStr | Malignancies in adult patients with common variable immunodeficiency |
| title_full_unstemmed | Malignancies in adult patients with common variable immunodeficiency |
| title_short | Malignancies in adult patients with common variable immunodeficiency |
| title_sort | malignancies in adult patients with common variable immunodeficiency |
| topic | inmunodeficiencia común variable linfoma neoplasia cáncer |
| url | http://revistaalergia.mx/ojs/index.php/ram/article/view/56 |
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