pH-responsive gelatin polymer-coated silica-based mesoporous composites for the sustained-release of indomethacin
This paper prepared drug-loaded mesoporous silica composites with a pH-responsive type. These composites were prepared by using three-dimensional caged silica (SBA-16) as the carrier, 3-aminopropyl trimethoxysilane (APTMS) as the silane coupling agent, and indomethacin (IMC) as the loaded drug, resp...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-03-01
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| Series: | Heliyon |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S240584402300912X |
| _version_ | 1797851915098259456 |
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| author | Bo Yu Ruiping Shi Chunlai Liu Zelong Liu Peihang Shen Jianglei Hu Fengwei Shi |
| author_facet | Bo Yu Ruiping Shi Chunlai Liu Zelong Liu Peihang Shen Jianglei Hu Fengwei Shi |
| author_sort | Bo Yu |
| collection | DOAJ |
| description | This paper prepared drug-loaded mesoporous silica composites with a pH-responsive type. These composites were prepared by using three-dimensional caged silica (SBA-16) as the carrier, 3-aminopropyl trimethoxysilane (APTMS) as the silane coupling agent, and indomethacin (IMC) as the loaded drug, respectively. The drug-loaded precursor NH2-SBA-16@IMC was prepared by solution diffusion adsorption. Finally, the pH-responsive drug-loaded composites NH2-SBA-16@IMC@GA were synthesized by wrapping the NH2-SBA-16@IMC with a condensation polymer of gelatin and glutaraldehyde. The composition and structure of the drug-loaded composites were characterized by FT-IR, XRD, TG, SEM, TEM, and N2 adsorption-desorption. The in vitro simulated release performance of the drug-loaded composites was investigated at 37 °C under three pH conditions. The results show that the NH2-SBA-16@IMC@GA can be released in response to specific pH environment, which can effectively control the release speed of the indomethacin. |
| first_indexed | 2024-04-09T19:25:34Z |
| format | Article |
| id | doaj.art-6c5ecbf7a8ac4671bd945ca36cbd9d53 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-04-09T19:25:34Z |
| publishDate | 2023-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-6c5ecbf7a8ac4671bd945ca36cbd9d532023-04-05T08:15:51ZengElsevierHeliyon2405-84402023-03-0193e13705pH-responsive gelatin polymer-coated silica-based mesoporous composites for the sustained-release of indomethacinBo Yu0Ruiping Shi1Chunlai Liu2Zelong Liu3Peihang Shen4Jianglei Hu5Fengwei Shi6School of Chemical Engineering & Advanced Institute of Materials Science, Changchun University of Technology, Changchun 130012, China; College of Pharmacy, Changchun University of Chinese Medicine, Changchun 130117, ChinaSchool of Chemical Engineering & Advanced Institute of Materials Science, Changchun University of Technology, Changchun 130012, ChinaSchool of Chemical Engineering & Advanced Institute of Materials Science, Changchun University of Technology, Changchun 130012, ChinaSchool of Chemical Engineering & Advanced Institute of Materials Science, Changchun University of Technology, Changchun 130012, ChinaSchool of Chemical Engineering & Advanced Institute of Materials Science, Changchun University of Technology, Changchun 130012, ChinaSchool of Chemical Engineering & Advanced Institute of Materials Science, Changchun University of Technology, Changchun 130012, China; Corresponding authors.School of Chemical Engineering & Advanced Institute of Materials Science, Changchun University of Technology, Changchun 130012, China; Corresponding authors.This paper prepared drug-loaded mesoporous silica composites with a pH-responsive type. These composites were prepared by using three-dimensional caged silica (SBA-16) as the carrier, 3-aminopropyl trimethoxysilane (APTMS) as the silane coupling agent, and indomethacin (IMC) as the loaded drug, respectively. The drug-loaded precursor NH2-SBA-16@IMC was prepared by solution diffusion adsorption. Finally, the pH-responsive drug-loaded composites NH2-SBA-16@IMC@GA were synthesized by wrapping the NH2-SBA-16@IMC with a condensation polymer of gelatin and glutaraldehyde. The composition and structure of the drug-loaded composites were characterized by FT-IR, XRD, TG, SEM, TEM, and N2 adsorption-desorption. The in vitro simulated release performance of the drug-loaded composites was investigated at 37 °C under three pH conditions. The results show that the NH2-SBA-16@IMC@GA can be released in response to specific pH environment, which can effectively control the release speed of the indomethacin.http://www.sciencedirect.com/science/article/pii/S240584402300912XSBA-16MesoporousGelatin coatingDrug carrierpH-responsiveIn vitro release |
| spellingShingle | Bo Yu Ruiping Shi Chunlai Liu Zelong Liu Peihang Shen Jianglei Hu Fengwei Shi pH-responsive gelatin polymer-coated silica-based mesoporous composites for the sustained-release of indomethacin Heliyon SBA-16 Mesoporous Gelatin coating Drug carrier pH-responsive In vitro release |
| title | pH-responsive gelatin polymer-coated silica-based mesoporous composites for the sustained-release of indomethacin |
| title_full | pH-responsive gelatin polymer-coated silica-based mesoporous composites for the sustained-release of indomethacin |
| title_fullStr | pH-responsive gelatin polymer-coated silica-based mesoporous composites for the sustained-release of indomethacin |
| title_full_unstemmed | pH-responsive gelatin polymer-coated silica-based mesoporous composites for the sustained-release of indomethacin |
| title_short | pH-responsive gelatin polymer-coated silica-based mesoporous composites for the sustained-release of indomethacin |
| title_sort | ph responsive gelatin polymer coated silica based mesoporous composites for the sustained release of indomethacin |
| topic | SBA-16 Mesoporous Gelatin coating Drug carrier pH-responsive In vitro release |
| url | http://www.sciencedirect.com/science/article/pii/S240584402300912X |
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