Fetal Hemoglobin and Tissue Oxygenation Measured With Near-Infrared Spectroscopy—A Systematic Qualitative Review
Fetal hemoglobin (HbF) is a principal oxygen carrier in the blood of preterm and term neonates. Compared to adult hemoglobin, it has a significantly higher affinity for oxygen and its oxyhemoglobin dissociation curve (ODC) is left-shifted accordingly. Tissue oxygenation measured with near-infrared s...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-08-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2021.710465/full |
| _version_ | 1818597886660706304 |
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| author | Ena Pritišanac Ena Pritišanac Berndt Urlesberger Berndt Urlesberger Bernhard Schwaberger Bernhard Schwaberger Gerhard Pichler Gerhard Pichler |
| author_facet | Ena Pritišanac Ena Pritišanac Berndt Urlesberger Berndt Urlesberger Bernhard Schwaberger Bernhard Schwaberger Gerhard Pichler Gerhard Pichler |
| author_sort | Ena Pritišanac |
| collection | DOAJ |
| description | Fetal hemoglobin (HbF) is a principal oxygen carrier in the blood of preterm and term neonates. Compared to adult hemoglobin, it has a significantly higher affinity for oxygen and its oxyhemoglobin dissociation curve (ODC) is left-shifted accordingly. Tissue oxygenation measured with near-infrared spectroscopy (NIRS) during neonatal intensive care is directly affected by hemoglobin concentration. We performed a systematic qualitative review regarding the impact of HbF on tissue oxygenation monitoring by NIRS. The PubMed/Medline, EMBASE, Cochrane library and CINAHL databases were searched from inception to May 2021 for studies relating to HbF and NIRS in preterm and term neonates in the first days and weeks after birth. Out of 1,429 eligible records, four observational studies were included. Three studies found no effect of HbF on cerebral tissue oxygenation. One peripheral NIRS study found a positive correlation between HbF and peripheral fractional oxygen extraction (FOE). Currently available limited data suggest that FHbF could affect peripheral muscle FOE, but seems not to affect cerebral oxygenation in preterm neonates. More studies are needed to draw a final conclusion on this matter, especially concerning the oxygenation changes driven by adult RBC transfusions. |
| first_indexed | 2024-12-16T11:54:56Z |
| format | Article |
| id | doaj.art-6c5f0d06f9a044f4b1394f1c3f88d47c |
| institution | Directory Open Access Journal |
| issn | 2296-2360 |
| language | English |
| last_indexed | 2024-12-16T11:54:56Z |
| publishDate | 2021-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj.art-6c5f0d06f9a044f4b1394f1c3f88d47c2022-12-21T22:32:36ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602021-08-01910.3389/fped.2021.710465710465Fetal Hemoglobin and Tissue Oxygenation Measured With Near-Infrared Spectroscopy—A Systematic Qualitative ReviewEna Pritišanac0Ena Pritišanac1Berndt Urlesberger2Berndt Urlesberger3Bernhard Schwaberger4Bernhard Schwaberger5Gerhard Pichler6Gerhard Pichler7Division of Neonatology, Department of Pediatrics, Medical University, Graz, AustriaResearch Unit for Neonatal Micro- and Macrocirculation, Medical University of Graz, Graz, AustriaDivision of Neonatology, Department of Pediatrics, Medical University, Graz, AustriaResearch Unit for Neonatal Micro- and Macrocirculation, Medical University of Graz, Graz, AustriaDivision of Neonatology, Department of Pediatrics, Medical University, Graz, AustriaResearch Unit for Neonatal Micro- and Macrocirculation, Medical University of Graz, Graz, AustriaDivision of Neonatology, Department of Pediatrics, Medical University, Graz, AustriaResearch Unit for Neonatal Micro- and Macrocirculation, Medical University of Graz, Graz, AustriaFetal hemoglobin (HbF) is a principal oxygen carrier in the blood of preterm and term neonates. Compared to adult hemoglobin, it has a significantly higher affinity for oxygen and its oxyhemoglobin dissociation curve (ODC) is left-shifted accordingly. Tissue oxygenation measured with near-infrared spectroscopy (NIRS) during neonatal intensive care is directly affected by hemoglobin concentration. We performed a systematic qualitative review regarding the impact of HbF on tissue oxygenation monitoring by NIRS. The PubMed/Medline, EMBASE, Cochrane library and CINAHL databases were searched from inception to May 2021 for studies relating to HbF and NIRS in preterm and term neonates in the first days and weeks after birth. Out of 1,429 eligible records, four observational studies were included. Three studies found no effect of HbF on cerebral tissue oxygenation. One peripheral NIRS study found a positive correlation between HbF and peripheral fractional oxygen extraction (FOE). Currently available limited data suggest that FHbF could affect peripheral muscle FOE, but seems not to affect cerebral oxygenation in preterm neonates. More studies are needed to draw a final conclusion on this matter, especially concerning the oxygenation changes driven by adult RBC transfusions.https://www.frontiersin.org/articles/10.3389/fped.2021.710465/fullfetal hemoglobinnewbornnear infrared spectroscopycerebral tissue oxygenationfractional oxygen extraction |
| spellingShingle | Ena Pritišanac Ena Pritišanac Berndt Urlesberger Berndt Urlesberger Bernhard Schwaberger Bernhard Schwaberger Gerhard Pichler Gerhard Pichler Fetal Hemoglobin and Tissue Oxygenation Measured With Near-Infrared Spectroscopy—A Systematic Qualitative Review Frontiers in Pediatrics fetal hemoglobin newborn near infrared spectroscopy cerebral tissue oxygenation fractional oxygen extraction |
| title | Fetal Hemoglobin and Tissue Oxygenation Measured With Near-Infrared Spectroscopy—A Systematic Qualitative Review |
| title_full | Fetal Hemoglobin and Tissue Oxygenation Measured With Near-Infrared Spectroscopy—A Systematic Qualitative Review |
| title_fullStr | Fetal Hemoglobin and Tissue Oxygenation Measured With Near-Infrared Spectroscopy—A Systematic Qualitative Review |
| title_full_unstemmed | Fetal Hemoglobin and Tissue Oxygenation Measured With Near-Infrared Spectroscopy—A Systematic Qualitative Review |
| title_short | Fetal Hemoglobin and Tissue Oxygenation Measured With Near-Infrared Spectroscopy—A Systematic Qualitative Review |
| title_sort | fetal hemoglobin and tissue oxygenation measured with near infrared spectroscopy a systematic qualitative review |
| topic | fetal hemoglobin newborn near infrared spectroscopy cerebral tissue oxygenation fractional oxygen extraction |
| url | https://www.frontiersin.org/articles/10.3389/fped.2021.710465/full |
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