Treatment of radiation-induced brain injury with bisdemethoxycurcumin
Radiation therapy is considered the most effective non-surgical treatment for brain tumors. However, there are no available treatments for radiation-induced brain injury. Bisdemethoxycurcumin (BDMC) is a demethoxy derivative of curcumin that has anti-proliferative, anti-inflammatory, and anti-oxidan...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2023-01-01
|
| Series: | Neural Regeneration Research |
| Subjects: | |
| Online Access: | http://www.nrronline.org/article.asp?issn=1673-5374;year=2023;volume=18;issue=2;spage=416;epage=421;aulast= |
| _version_ | 1811342234472153088 |
|---|---|
| author | Yun-Qian Chang Gui-Juan Zhou Hong-Mei Wen Duan-Qun He Chen-Lin Xu Ya-Rui Chen Yi-Hui Li Shuang-Xi Chen Zi-Jian Xiao Ming Xie |
| author_facet | Yun-Qian Chang Gui-Juan Zhou Hong-Mei Wen Duan-Qun He Chen-Lin Xu Ya-Rui Chen Yi-Hui Li Shuang-Xi Chen Zi-Jian Xiao Ming Xie |
| author_sort | Yun-Qian Chang |
| collection | DOAJ |
| description | Radiation therapy is considered the most effective non-surgical treatment for brain tumors. However, there are no available treatments for radiation-induced brain injury. Bisdemethoxycurcumin (BDMC) is a demethoxy derivative of curcumin that has anti-proliferative, anti-inflammatory, and anti-oxidant properties. To determine whether BDMC has the potential to treat radiation-induced brain injury, in this study, we established a rat model of radiation-induced brain injury by administering a single 30-Gy vertical dose of irradiation to the whole brain, followed by intraperitoneal injection of 500 μL of a 100 mg/kg BDMC solution every day for 5 successive weeks. Our results showed that BDMC increased the body weight of rats with radiation-induced brain injury, improved learning and memory, attenuated brain edema, inhibited astrocyte activation, and reduced oxidative stress. These findings suggest that BDMC protects against radiation-induced brain injury. |
| first_indexed | 2024-04-13T19:08:02Z |
| format | Article |
| id | doaj.art-6c606ece658d4e298da8b0ace3f3db4c |
| institution | Directory Open Access Journal |
| issn | 1673-5374 |
| language | English |
| last_indexed | 2024-04-13T19:08:02Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Neural Regeneration Research |
| spelling | doaj.art-6c606ece658d4e298da8b0ace3f3db4c2022-12-22T02:33:55ZengWolters Kluwer Medknow PublicationsNeural Regeneration Research1673-53742023-01-0118241642110.4103/1673-5374.346549Treatment of radiation-induced brain injury with bisdemethoxycurcuminYun-Qian ChangGui-Juan ZhouHong-Mei WenDuan-Qun HeChen-Lin XuYa-Rui ChenYi-Hui LiShuang-Xi ChenZi-Jian XiaoMing XieRadiation therapy is considered the most effective non-surgical treatment for brain tumors. However, there are no available treatments for radiation-induced brain injury. Bisdemethoxycurcumin (BDMC) is a demethoxy derivative of curcumin that has anti-proliferative, anti-inflammatory, and anti-oxidant properties. To determine whether BDMC has the potential to treat radiation-induced brain injury, in this study, we established a rat model of radiation-induced brain injury by administering a single 30-Gy vertical dose of irradiation to the whole brain, followed by intraperitoneal injection of 500 μL of a 100 mg/kg BDMC solution every day for 5 successive weeks. Our results showed that BDMC increased the body weight of rats with radiation-induced brain injury, improved learning and memory, attenuated brain edema, inhibited astrocyte activation, and reduced oxidative stress. These findings suggest that BDMC protects against radiation-induced brain injury.http://www.nrronline.org/article.asp?issn=1673-5374;year=2023;volume=18;issue=2;spage=416;epage=421;aulast=astrocytes; bisdemethoxycurcumin; brain edema; brain tumor; curcumin; learning and memory; neuronal injury; oxidative stress; radiation therapy; radiation-induced brain injury |
| spellingShingle | Yun-Qian Chang Gui-Juan Zhou Hong-Mei Wen Duan-Qun He Chen-Lin Xu Ya-Rui Chen Yi-Hui Li Shuang-Xi Chen Zi-Jian Xiao Ming Xie Treatment of radiation-induced brain injury with bisdemethoxycurcumin Neural Regeneration Research astrocytes; bisdemethoxycurcumin; brain edema; brain tumor; curcumin; learning and memory; neuronal injury; oxidative stress; radiation therapy; radiation-induced brain injury |
| title | Treatment of radiation-induced brain injury with bisdemethoxycurcumin |
| title_full | Treatment of radiation-induced brain injury with bisdemethoxycurcumin |
| title_fullStr | Treatment of radiation-induced brain injury with bisdemethoxycurcumin |
| title_full_unstemmed | Treatment of radiation-induced brain injury with bisdemethoxycurcumin |
| title_short | Treatment of radiation-induced brain injury with bisdemethoxycurcumin |
| title_sort | treatment of radiation induced brain injury with bisdemethoxycurcumin |
| topic | astrocytes; bisdemethoxycurcumin; brain edema; brain tumor; curcumin; learning and memory; neuronal injury; oxidative stress; radiation therapy; radiation-induced brain injury |
| url | http://www.nrronline.org/article.asp?issn=1673-5374;year=2023;volume=18;issue=2;spage=416;epage=421;aulast= |
| work_keys_str_mv | AT yunqianchang treatmentofradiationinducedbraininjurywithbisdemethoxycurcumin AT guijuanzhou treatmentofradiationinducedbraininjurywithbisdemethoxycurcumin AT hongmeiwen treatmentofradiationinducedbraininjurywithbisdemethoxycurcumin AT duanqunhe treatmentofradiationinducedbraininjurywithbisdemethoxycurcumin AT chenlinxu treatmentofradiationinducedbraininjurywithbisdemethoxycurcumin AT yaruichen treatmentofradiationinducedbraininjurywithbisdemethoxycurcumin AT yihuili treatmentofradiationinducedbraininjurywithbisdemethoxycurcumin AT shuangxichen treatmentofradiationinducedbraininjurywithbisdemethoxycurcumin AT zijianxiao treatmentofradiationinducedbraininjurywithbisdemethoxycurcumin AT mingxie treatmentofradiationinducedbraininjurywithbisdemethoxycurcumin |