Neuroprotective effects of electroacupuncture on hypoxic-ischemic encephalopathy in newborn rats association with increased expression of mTOR
In this study, we observed the therapeutic effects of acupuncture and investigated the underlying molecular mechanisms by constructed a hypoxic-ischemic encephalopathy (HIE) animal model. In the electroacupuncture group, mTOR expression increased since 1d, and continued to rise till the 21st day. Al...
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| Format: | Article |
| Language: | English |
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Bangladesh Pharmacological Society
2016-03-01
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| Series: | Bangladesh Journal of Pharmacology |
| Subjects: | |
| Online Access: | https://www.banglajol.info/index.php/BJP/article/view/26418 |
| _version_ | 1818084754458673152 |
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| author | Tao Xu Na Zhao Jing-Dong Liu Mo Xiao-Mei Hui Zhang Peng-Fei Qin Xiang-Chun Feng Qing Sun |
| author_facet | Tao Xu Na Zhao Jing-Dong Liu Mo Xiao-Mei Hui Zhang Peng-Fei Qin Xiang-Chun Feng Qing Sun |
| author_sort | Tao Xu |
| collection | DOAJ |
| description | In this study, we observed the therapeutic effects of acupuncture and investigated the underlying molecular mechanisms by constructed a hypoxic-ischemic encephalopathy (HIE) animal model. In the electroacupuncture group, mTOR expression increased since 1d, and continued to rise till the 21st day. All of the differences were significantly (p<0.05 vs the model group). Meanwhile, mTOR expression was analyzed by Western blotting. There was statistical significance between the model group and the electroacupuncture group in the four time periods (p<0.05). The results provide evidence that electroacupuncture treatment protected cortical neurons against HIE-induced neuronal damage and degenerative changes in rats, which is in association with activation of mTOR both at the mRNA level and protein level. Therefore, electroacupuncture may become a potential therapeutic strategy for HIE of newborn. |
| first_indexed | 2024-12-10T19:58:55Z |
| format | Article |
| id | doaj.art-6c6183c77eac4549af5ae6d8fe3ae6a6 |
| institution | Directory Open Access Journal |
| issn | 1991-0088 |
| language | English |
| last_indexed | 2024-12-10T19:58:55Z |
| publishDate | 2016-03-01 |
| publisher | Bangladesh Pharmacological Society |
| record_format | Article |
| series | Bangladesh Journal of Pharmacology |
| spelling | doaj.art-6c6183c77eac4549af5ae6d8fe3ae6a62022-12-22T01:35:34ZengBangladesh Pharmacological SocietyBangladesh Journal of Pharmacology1991-00882016-03-0111S1Neuroprotective effects of electroacupuncture on hypoxic-ischemic encephalopathy in newborn rats association with increased expression of mTORTao Xu0Na Zhao1Jing-Dong Liu2Mo Xiao-Mei3Hui Zhang4Peng-Fei Qin5Xiang-Chun Feng6Qing Sun7Qingdao Women and Children Hospital, Qingdao, Shangdong, 266000Qingdao Women and Children Hospital, Qingdao, Shangdong, 266000Qingdao Women and Children Hospital, Qingdao, Shangdong, 266000Qingdao Women and Children Hospital, Qingdao, Shangdong, 266000Qingdao University Medical College, Qingdao, Shangdong, 266000Qingdao Women and Children Hospital, Qingdao, Shangdong, 266000Qingdao Women and Children Hospital, Qingdao, Shangdong, 266000Qingdao Women and Children Hospital, Qingdao, Shangdong, 266000In this study, we observed the therapeutic effects of acupuncture and investigated the underlying molecular mechanisms by constructed a hypoxic-ischemic encephalopathy (HIE) animal model. In the electroacupuncture group, mTOR expression increased since 1d, and continued to rise till the 21st day. All of the differences were significantly (p<0.05 vs the model group). Meanwhile, mTOR expression was analyzed by Western blotting. There was statistical significance between the model group and the electroacupuncture group in the four time periods (p<0.05). The results provide evidence that electroacupuncture treatment protected cortical neurons against HIE-induced neuronal damage and degenerative changes in rats, which is in association with activation of mTOR both at the mRNA level and protein level. Therefore, electroacupuncture may become a potential therapeutic strategy for HIE of newborn.https://www.banglajol.info/index.php/BJP/article/view/26418ElectroacupunctureHypoxic-ischemic encephalopathymTORNeuroprotectiveNewborn |
| spellingShingle | Tao Xu Na Zhao Jing-Dong Liu Mo Xiao-Mei Hui Zhang Peng-Fei Qin Xiang-Chun Feng Qing Sun Neuroprotective effects of electroacupuncture on hypoxic-ischemic encephalopathy in newborn rats association with increased expression of mTOR Bangladesh Journal of Pharmacology Electroacupuncture Hypoxic-ischemic encephalopathy mTOR Neuroprotective Newborn |
| title | Neuroprotective effects of electroacupuncture on hypoxic-ischemic encephalopathy in newborn rats association with increased expression of mTOR |
| title_full | Neuroprotective effects of electroacupuncture on hypoxic-ischemic encephalopathy in newborn rats association with increased expression of mTOR |
| title_fullStr | Neuroprotective effects of electroacupuncture on hypoxic-ischemic encephalopathy in newborn rats association with increased expression of mTOR |
| title_full_unstemmed | Neuroprotective effects of electroacupuncture on hypoxic-ischemic encephalopathy in newborn rats association with increased expression of mTOR |
| title_short | Neuroprotective effects of electroacupuncture on hypoxic-ischemic encephalopathy in newborn rats association with increased expression of mTOR |
| title_sort | neuroprotective effects of electroacupuncture on hypoxic ischemic encephalopathy in newborn rats association with increased expression of mtor |
| topic | Electroacupuncture Hypoxic-ischemic encephalopathy mTOR Neuroprotective Newborn |
| url | https://www.banglajol.info/index.php/BJP/article/view/26418 |
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