Oncolytic adeno-immunotherapy modulates the immune system enabling CAR T-cells to cure pancreatic tumors
Rosewell Shaw et al. show that a previously developed immunotherapy strategy, coupling oncolytic adenoviral immunotherapy with clinically tested HER2-specific CAR T-cells, is effective against pancreatic ductal adenocarcinoma (PDAC). This combination therapy produces a curative response in both PDAC...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-03-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-021-01914-8 |
| _version_ | 1818722456557322240 |
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| author | Amanda Rosewell Shaw Caroline E. Porter Tiffany Yip Way-Champ Mah Mary K. McKenna Matthew Dysthe Youngrock Jung Robin Parihar Malcolm K. Brenner Masataka Suzuki |
| author_facet | Amanda Rosewell Shaw Caroline E. Porter Tiffany Yip Way-Champ Mah Mary K. McKenna Matthew Dysthe Youngrock Jung Robin Parihar Malcolm K. Brenner Masataka Suzuki |
| author_sort | Amanda Rosewell Shaw |
| collection | DOAJ |
| description | Rosewell Shaw et al. show that a previously developed immunotherapy strategy, coupling oncolytic adenoviral immunotherapy with clinically tested HER2-specific CAR T-cells, is effective against pancreatic ductal adenocarcinoma (PDAC). This combination therapy produces a curative response in both PDAC xenografts and humanized mouse models. |
| first_indexed | 2024-12-17T20:54:55Z |
| format | Article |
| id | doaj.art-6c619b9e136441a696783c518011c56f |
| institution | Directory Open Access Journal |
| issn | 2399-3642 |
| language | English |
| last_indexed | 2024-12-17T20:54:55Z |
| publishDate | 2021-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj.art-6c619b9e136441a696783c518011c56f2022-12-21T21:32:54ZengNature PortfolioCommunications Biology2399-36422021-03-014111310.1038/s42003-021-01914-8Oncolytic adeno-immunotherapy modulates the immune system enabling CAR T-cells to cure pancreatic tumorsAmanda Rosewell Shaw0Caroline E. Porter1Tiffany Yip2Way-Champ Mah3Mary K. McKenna4Matthew Dysthe5Youngrock Jung6Robin Parihar7Malcolm K. Brenner8Masataka Suzuki9Department of Medicine, Section of Hematology/Oncology, Baylor College of MedicineDepartment of Medicine, Section of Hematology/Oncology, Baylor College of MedicineDepartment of Medicine, Section of Hematology/Oncology, Baylor College of MedicineDepartment of Medicine, Section of Hematology/Oncology, Baylor College of MedicineCenter for Cell and Gene Therapy, Baylor College of Medicine, Texas Children’s Hospital, Houston Methodist HospitalCenter for Cell and Gene Therapy, Baylor College of Medicine, Texas Children’s Hospital, Houston Methodist HospitalDepartment of Medicine, Section of Hematology/Oncology, Baylor College of MedicineCenter for Cell and Gene Therapy, Baylor College of Medicine, Texas Children’s Hospital, Houston Methodist HospitalDepartment of Medicine, Section of Hematology/Oncology, Baylor College of MedicineDepartment of Medicine, Section of Hematology/Oncology, Baylor College of MedicineRosewell Shaw et al. show that a previously developed immunotherapy strategy, coupling oncolytic adenoviral immunotherapy with clinically tested HER2-specific CAR T-cells, is effective against pancreatic ductal adenocarcinoma (PDAC). This combination therapy produces a curative response in both PDAC xenografts and humanized mouse models.https://doi.org/10.1038/s42003-021-01914-8 |
| spellingShingle | Amanda Rosewell Shaw Caroline E. Porter Tiffany Yip Way-Champ Mah Mary K. McKenna Matthew Dysthe Youngrock Jung Robin Parihar Malcolm K. Brenner Masataka Suzuki Oncolytic adeno-immunotherapy modulates the immune system enabling CAR T-cells to cure pancreatic tumors Communications Biology |
| title | Oncolytic adeno-immunotherapy modulates the immune system enabling CAR T-cells to cure pancreatic tumors |
| title_full | Oncolytic adeno-immunotherapy modulates the immune system enabling CAR T-cells to cure pancreatic tumors |
| title_fullStr | Oncolytic adeno-immunotherapy modulates the immune system enabling CAR T-cells to cure pancreatic tumors |
| title_full_unstemmed | Oncolytic adeno-immunotherapy modulates the immune system enabling CAR T-cells to cure pancreatic tumors |
| title_short | Oncolytic adeno-immunotherapy modulates the immune system enabling CAR T-cells to cure pancreatic tumors |
| title_sort | oncolytic adeno immunotherapy modulates the immune system enabling car t cells to cure pancreatic tumors |
| url | https://doi.org/10.1038/s42003-021-01914-8 |
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