Plasma Docosahexaenoic Acid and Eicosapentaenoic Acid Concentrations Are Positively Associated with Brown Adipose Tissue Activity in Humans
Brown adipose tissue (BAT) activation is a possible therapeutic strategy to increase energy expenditure and improve metabolic homeostasis in obesity. Recent studies have revealed novel interactions between BAT and circulating lipid species—in particular, the non-esterified fatty acid (NEFA) and oxyl...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-09-01
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| Series: | Metabolites |
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| Online Access: | https://www.mdpi.com/2218-1989/10/10/388 |
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| author | Angie S. Xiang Corey Giles Rebecca K.C. Loh Melissa F. Formosa Nina Eikelis Gavin W. Lambert Peter J. Meikle Bronwyn A. Kingwell Andrew L. Carey |
| author_facet | Angie S. Xiang Corey Giles Rebecca K.C. Loh Melissa F. Formosa Nina Eikelis Gavin W. Lambert Peter J. Meikle Bronwyn A. Kingwell Andrew L. Carey |
| author_sort | Angie S. Xiang |
| collection | DOAJ |
| description | Brown adipose tissue (BAT) activation is a possible therapeutic strategy to increase energy expenditure and improve metabolic homeostasis in obesity. Recent studies have revealed novel interactions between BAT and circulating lipid species—in particular, the non-esterified fatty acid (NEFA) and oxylipin lipid classes. This study aimed to identify individual lipid species that may be associated with cold-stimulated BAT activity in humans. A panel of 44 NEFA and 41 oxylipin species were measured using mass-spectrometry-based lipidomics in the plasma of fourteen healthy male participants before and after 90 min of mild cold exposure. Lipid measures were correlated with BAT activity measured via <sup>18</sup>F-fluorodeoxyglucose ([<sup>18</sup>F]FDG) positron emission tomography/computed tomography (PET/CT), along with norepinephrine (NE) concentration (a surrogate marker of sympathetic activity). The study identified a significant increase in total NEFA concentration following cold exposure that was positively associated with NE concentration change. Individually, 33 NEFA and 11 oxylipin species increased significantly in response to cold exposure. The concentration of the omega-3 NEFA, docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) at baseline was significantly associated with BAT activity, and the cold-induced change in 18 NEFA species was significantly associated with BAT activity. No significant associations were identified between BAT activity and oxylipins. |
| first_indexed | 2024-03-10T15:58:49Z |
| format | Article |
| id | doaj.art-6c61a19519ad4ebabf7b14d60dac01d3 |
| institution | Directory Open Access Journal |
| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-03-10T15:58:49Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj.art-6c61a19519ad4ebabf7b14d60dac01d32023-11-20T15:26:08ZengMDPI AGMetabolites2218-19892020-09-01101038810.3390/metabo10100388Plasma Docosahexaenoic Acid and Eicosapentaenoic Acid Concentrations Are Positively Associated with Brown Adipose Tissue Activity in HumansAngie S. Xiang0Corey Giles1Rebecca K.C. Loh2Melissa F. Formosa3Nina Eikelis4Gavin W. Lambert5Peter J. Meikle6Bronwyn A. Kingwell7Andrew L. Carey8Metabolic and Vascular Physiology Laboratory, Baker Heart and Diabetes Institute, Melbourne 3004, AustraliaMetabolomics Laboratory, Baker Heart and Diabetes Institute, Melbourne 3004, AustraliaMetabolic and Vascular Physiology Laboratory, Baker Heart and Diabetes Institute, Melbourne 3004, AustraliaMetabolic and Vascular Physiology Laboratory, Baker Heart and Diabetes Institute, Melbourne 3004, AustraliaIverson Health Innovation Research Institute, Swinburne Institute of Technology, Melbourne 3122, AustraliaIverson Health Innovation Research Institute, Swinburne Institute of Technology, Melbourne 3122, AustraliaMetabolomics Laboratory, Baker Heart and Diabetes Institute, Melbourne 3004, AustraliaMetabolic and Vascular Physiology Laboratory, Baker Heart and Diabetes Institute, Melbourne 3004, AustraliaMetabolic and Vascular Physiology Laboratory, Baker Heart and Diabetes Institute, Melbourne 3004, AustraliaBrown adipose tissue (BAT) activation is a possible therapeutic strategy to increase energy expenditure and improve metabolic homeostasis in obesity. Recent studies have revealed novel interactions between BAT and circulating lipid species—in particular, the non-esterified fatty acid (NEFA) and oxylipin lipid classes. This study aimed to identify individual lipid species that may be associated with cold-stimulated BAT activity in humans. A panel of 44 NEFA and 41 oxylipin species were measured using mass-spectrometry-based lipidomics in the plasma of fourteen healthy male participants before and after 90 min of mild cold exposure. Lipid measures were correlated with BAT activity measured via <sup>18</sup>F-fluorodeoxyglucose ([<sup>18</sup>F]FDG) positron emission tomography/computed tomography (PET/CT), along with norepinephrine (NE) concentration (a surrogate marker of sympathetic activity). The study identified a significant increase in total NEFA concentration following cold exposure that was positively associated with NE concentration change. Individually, 33 NEFA and 11 oxylipin species increased significantly in response to cold exposure. The concentration of the omega-3 NEFA, docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) at baseline was significantly associated with BAT activity, and the cold-induced change in 18 NEFA species was significantly associated with BAT activity. No significant associations were identified between BAT activity and oxylipins.https://www.mdpi.com/2218-1989/10/10/388fatty acidsfish oillipidomicsmass spectrometryobesityBAT |
| spellingShingle | Angie S. Xiang Corey Giles Rebecca K.C. Loh Melissa F. Formosa Nina Eikelis Gavin W. Lambert Peter J. Meikle Bronwyn A. Kingwell Andrew L. Carey Plasma Docosahexaenoic Acid and Eicosapentaenoic Acid Concentrations Are Positively Associated with Brown Adipose Tissue Activity in Humans Metabolites fatty acids fish oil lipidomics mass spectrometry obesity BAT |
| title | Plasma Docosahexaenoic Acid and Eicosapentaenoic Acid Concentrations Are Positively Associated with Brown Adipose Tissue Activity in Humans |
| title_full | Plasma Docosahexaenoic Acid and Eicosapentaenoic Acid Concentrations Are Positively Associated with Brown Adipose Tissue Activity in Humans |
| title_fullStr | Plasma Docosahexaenoic Acid and Eicosapentaenoic Acid Concentrations Are Positively Associated with Brown Adipose Tissue Activity in Humans |
| title_full_unstemmed | Plasma Docosahexaenoic Acid and Eicosapentaenoic Acid Concentrations Are Positively Associated with Brown Adipose Tissue Activity in Humans |
| title_short | Plasma Docosahexaenoic Acid and Eicosapentaenoic Acid Concentrations Are Positively Associated with Brown Adipose Tissue Activity in Humans |
| title_sort | plasma docosahexaenoic acid and eicosapentaenoic acid concentrations are positively associated with brown adipose tissue activity in humans |
| topic | fatty acids fish oil lipidomics mass spectrometry obesity BAT |
| url | https://www.mdpi.com/2218-1989/10/10/388 |
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