Non-invasive 40-Hz Light Flicker Ameliorates Alzheimer’s-Associated Rhythm Disorder via Regulating Central Circadian Clock in Mice

Non-invasive 40-Hz Light Flicker Ameliorates Alzheimer’s-Associated Rhythm Disorder via Regulating Central Circadian Clock in Mice

Alzheimer’s disease (AD) patients often exhibit perturbed circadian rhythm with fragmented sleep before disease onset. This study was designed to evaluate the effect of a 40-Hz light flicker on circadian rhythm in an AD mouse model (APP/PS1). Locomotor rhythms recordings were conducted to examine th...

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Bibliographic Details
Main Authors: Youli Yao, Ying Ying, Qiyu Deng, Wenjiang Zhang, Huazhang Zhu, Zhenglong Lin, Shengli Zhang, Junxian Ma, Yingying Zhao
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Physiology
Subjects:
40-Hz light flicker
Alzheimer’s disease
rhythm disorders
SCN neurons
circadian clock
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2020.00294/full

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