From maternal breath to infant's cells: Impact of maternal respiratory infections on infants ‘immune responses
In utero exposure to maternally-derived antigens following chronic infection is associated with modulation of infants ‘immune response, differential susceptibility to post-natal infections and immune response toward vaccines. The maternal environment, both internal (microbiota) and external (exposur...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Pediatrics |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2022.1046100/full |
| _version_ | 1811223735791779840 |
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| author | Nicolas Dauby Nicolas Dauby Nicolas Dauby Véronique Flamand |
| author_facet | Nicolas Dauby Nicolas Dauby Nicolas Dauby Véronique Flamand |
| author_sort | Nicolas Dauby |
| collection | DOAJ |
| description | In utero exposure to maternally-derived antigens following chronic infection is associated with modulation of infants ‘immune response, differential susceptibility to post-natal infections and immune response toward vaccines. The maternal environment, both internal (microbiota) and external (exposure to environmental microbes) also modulates infant's immune response but also the clinical phenotype after birth. Vertical transmission of ubiquitous respiratory pathogens such as influenza and COVID-19 is uncommon. Evidence suggest that in utero exposure to maternal influenza and SARS-CoV-2 infections may have a significant impact on the developing immune system with activation of both innate and adaptive responses, possibly related to placental inflammation. Here in, we review how maternal respiratory infections, associated with airway, systemic and placental inflammation but also changes in maternal microbiota might impact infant's immune responses after birth. The clinical impact of immune modifications observed following maternal respiratory infections remains unexplored. Given the high frequencies of respiratory infections during pregnancy (COVID-19, influenza but also RSV and HMPV), the impact on global child health could be important. |
| first_indexed | 2024-04-12T08:37:24Z |
| format | Article |
| id | doaj.art-6c644d4665d7482fbd40da261a69a871 |
| institution | Directory Open Access Journal |
| issn | 2296-2360 |
| language | English |
| last_indexed | 2024-04-12T08:37:24Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj.art-6c644d4665d7482fbd40da261a69a8712022-12-22T03:39:58ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602022-11-011010.3389/fped.2022.10461001046100From maternal breath to infant's cells: Impact of maternal respiratory infections on infants ‘immune responsesNicolas Dauby0Nicolas Dauby1Nicolas Dauby2Véronique Flamand3Institute for Medical Immunology, ULB Center for Research in Immunology, Université Libre de Bruxelles (ULB), Brussels, BelgiumDepartment of Infectious Diseases, CHU Saint-Pierre, Brussels, BelgiumSchool of Public Health, Université Libre de Bruxelles (ULB), Brussels, BelgiumInstitute for Medical Immunology, ULB Center for Research in Immunology, Université Libre de Bruxelles (ULB), Brussels, BelgiumIn utero exposure to maternally-derived antigens following chronic infection is associated with modulation of infants ‘immune response, differential susceptibility to post-natal infections and immune response toward vaccines. The maternal environment, both internal (microbiota) and external (exposure to environmental microbes) also modulates infant's immune response but also the clinical phenotype after birth. Vertical transmission of ubiquitous respiratory pathogens such as influenza and COVID-19 is uncommon. Evidence suggest that in utero exposure to maternal influenza and SARS-CoV-2 infections may have a significant impact on the developing immune system with activation of both innate and adaptive responses, possibly related to placental inflammation. Here in, we review how maternal respiratory infections, associated with airway, systemic and placental inflammation but also changes in maternal microbiota might impact infant's immune responses after birth. The clinical impact of immune modifications observed following maternal respiratory infections remains unexplored. Given the high frequencies of respiratory infections during pregnancy (COVID-19, influenza but also RSV and HMPV), the impact on global child health could be important.https://www.frontiersin.org/articles/10.3389/fped.2022.1046100/fullCOVID-19SARS-CoV-2influenzapregnancyfetal immunitymicrobiota |
| spellingShingle | Nicolas Dauby Nicolas Dauby Nicolas Dauby Véronique Flamand From maternal breath to infant's cells: Impact of maternal respiratory infections on infants ‘immune responses Frontiers in Pediatrics COVID-19 SARS-CoV-2 influenza pregnancy fetal immunity microbiota |
| title | From maternal breath to infant's cells: Impact of maternal respiratory infections on infants ‘immune responses |
| title_full | From maternal breath to infant's cells: Impact of maternal respiratory infections on infants ‘immune responses |
| title_fullStr | From maternal breath to infant's cells: Impact of maternal respiratory infections on infants ‘immune responses |
| title_full_unstemmed | From maternal breath to infant's cells: Impact of maternal respiratory infections on infants ‘immune responses |
| title_short | From maternal breath to infant's cells: Impact of maternal respiratory infections on infants ‘immune responses |
| title_sort | from maternal breath to infant s cells impact of maternal respiratory infections on infants immune responses |
| topic | COVID-19 SARS-CoV-2 influenza pregnancy fetal immunity microbiota |
| url | https://www.frontiersin.org/articles/10.3389/fped.2022.1046100/full |
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