Effects of Previous Overt Hyperthyroidism due to Graves’ Disease on Bone Mineral Density (BMD) in Euthyroid Pre and Post Menopausal Females
Background: To determine the effects of previous overt hyperthyroidism due to Graves’ disease on BMD in euthyroid pre and post menopausal females. Methods: In this cross-sectional, non-interventional study,fifty patients with previous hyperthyroidism due to Graves’ disease (premenopausal:25, postmen...
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| Format: | Article |
| Language: | English |
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Rawalpindi Medical University
2015-06-01
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| Series: | Journal of Rawalpindi Medical College |
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| Online Access: | https://www.journalrmc.com/index.php/JRMC/article/view/273 |
| Summary: | Background: To determine the effects of previous overt hyperthyroidism due to Graves’ disease on BMD in euthyroid pre and post menopausal females.
Methods: In this cross-sectional, non-interventional study,fifty patients with previous hyperthyroidism due to Graves’ disease (premenopausal:25, postmenopausal: 25) who remained euthyroid for at least 6 months prior to study were included and compared with fifty- matched respective controls. Free thyroxine (FT4), TSH, and BMD were measured. Comparison was made between two groups and also between patients and controls in each group.
Results: Statistically significant (p <.0.05) lower whole body BMD expressed as Z-score was observed in post-menopausal women having history of hyperthyroidism due to Graves’ disease than matched controls. Bone mineral density, expressed as Z-score in whole body and lumbar spine was significantly lower in group II (post-menopause) in comparison to group I (pre-menopause) patients. Time of euthyroidism and time of evolution of disease has significant effect on BMD in post-menopausal women.
Conclusion: Graves’ hyperthyroidism affects BMD only in post menopausal females even after achievement of euthyroid status. |
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| ISSN: | 1683-3562 1683-3570 |