Effects of aqueous and ethanolic extracts of Peganum harmala L seeds on lipids profile in rats
Background and Aim: Atherosclerosis is the main factor of mortality in cardiovascular patients. Pathogenesis dependence of atherosclerosis on the increase of low density lipoprotein cholesterol (LDL-c) has been proved. Since using of existing chemical medicines for the treatment of cardiovascular di...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | fas |
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Birjand University of Medical Sciences and Health Services
2013-08-01
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| Series: | مجله دانشگاه علوم پزشکی بیرجند |
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| Online Access: | http://journal.bums.ac.ir/browse.php?a_code=A-10-316-2&slc_lang=en&sid=1 |
| _version_ | 1811257631034048512 |
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| author | Mohammad Mehdi Hasanzadeh Tahery Mohammad Hasanpour Fard Navid Rabiee Sayed Amir Reza Ghoreishe Naeem Ravanbakhsh |
| author_facet | Mohammad Mehdi Hasanzadeh Tahery Mohammad Hasanpour Fard Navid Rabiee Sayed Amir Reza Ghoreishe Naeem Ravanbakhsh |
| author_sort | Mohammad Mehdi Hasanzadeh Tahery |
| collection | DOAJ |
| description | Background and Aim: Atherosclerosis is the main factor of mortality in cardiovascular patients. Pathogenesis dependence of atherosclerosis on the increase of low density lipoprotein cholesterol (LDL-c) has been proved. Since using of existing chemical medicines for the treatment of cardiovascular diseases causes several side-effects, this has led to more tendency to using of herbs. According to some traditional medicinal references, Harmala seeds can be used as lowering blood lipids agents. The aim of the present study was to determine the effects of aqueous and ethanolic extracts of Harmala seeds on blood lipid profiles. Materials and Methods: In this experimental study 18 Wistar rats with the average weight of 300 g were used. The rats were randomly divided into three groups, i.e. two experimental and one control group. The experimental groups I and II were respectively gavaged 3cc liquid containing 100mg/kg body weight (bw) of aqueous and ethanolic extract of Harmala seeds for 30 days and group III, as a negative control, received an equal volume of distilled water for the same period. At the end , after deep anesthesia of the subjects with ether, the amount of blood lipids such as triglyceride (TG), total cholesterol (TC), LDL, and HDL were measured using test kits and the amount of VLDL cholesterol, too, was mathematically calculated. The obtained data was analyzed by means of SPSS software (v: 11.5), ANOVA and Tukey tests at the significant level P<0.05. Results: The findings showed that mean levels of LDL cholesterol in groups I, II, and control was 36.8±4.3, 35.8±4.3 and 44.3±4.6, respectively. Comparatively, the difference between experimental group I and the control (P=0.025) and also between group II and the control (P=0.012) were statistically significant. The other tested blood lipids in the experimental groups and the control group did not show a significant difference. Conclusion: It was found that consumption of Harmala seed can significantly reduce LDL cholesterol and the ethanolic extract of the herb is more effective than the aqueous one. |
| first_indexed | 2024-04-12T18:00:30Z |
| format | Article |
| id | doaj.art-6c653f0be7374ce3a3ca463789a91d9b |
| institution | Directory Open Access Journal |
| issn | 1607-2197 2423-6152 |
| language | fas |
| last_indexed | 2024-04-12T18:00:30Z |
| publishDate | 2013-08-01 |
| publisher | Birjand University of Medical Sciences and Health Services |
| record_format | Article |
| series | مجله دانشگاه علوم پزشکی بیرجند |
| spelling | doaj.art-6c653f0be7374ce3a3ca463789a91d9b2022-12-22T03:22:11ZfasBirjand University of Medical Sciences and Health Servicesمجله دانشگاه علوم پزشکی بیرجند1607-21972423-61522013-08-01202108114Effects of aqueous and ethanolic extracts of Peganum harmala L seeds on lipids profile in ratsMohammad Mehdi Hasanzadeh Tahery0Mohammad Hasanpour Fard1Navid Rabiee2Sayed Amir Reza Ghoreishe3Naeem Ravanbakhsh4 Faculty of Medicine, Birjand University of Medical Science Department of Physiology and Pharmacology, Faculty of Medicine, Birjand University of Medical Science Birjand University of Medical Science, Birjand, Iran Birjand University of Medical Science, Birjand, Iran Birjand University of Medical Science, Birjand, Iran Background and Aim: Atherosclerosis is the main factor of mortality in cardiovascular patients. Pathogenesis dependence of atherosclerosis on the increase of low density lipoprotein cholesterol (LDL-c) has been proved. Since using of existing chemical medicines for the treatment of cardiovascular diseases causes several side-effects, this has led to more tendency to using of herbs. According to some traditional medicinal references, Harmala seeds can be used as lowering blood lipids agents. The aim of the present study was to determine the effects of aqueous and ethanolic extracts of Harmala seeds on blood lipid profiles. Materials and Methods: In this experimental study 18 Wistar rats with the average weight of 300 g were used. The rats were randomly divided into three groups, i.e. two experimental and one control group. The experimental groups I and II were respectively gavaged 3cc liquid containing 100mg/kg body weight (bw) of aqueous and ethanolic extract of Harmala seeds for 30 days and group III, as a negative control, received an equal volume of distilled water for the same period. At the end , after deep anesthesia of the subjects with ether, the amount of blood lipids such as triglyceride (TG), total cholesterol (TC), LDL, and HDL were measured using test kits and the amount of VLDL cholesterol, too, was mathematically calculated. The obtained data was analyzed by means of SPSS software (v: 11.5), ANOVA and Tukey tests at the significant level P<0.05. Results: The findings showed that mean levels of LDL cholesterol in groups I, II, and control was 36.8±4.3, 35.8±4.3 and 44.3±4.6, respectively. Comparatively, the difference between experimental group I and the control (P=0.025) and also between group II and the control (P=0.012) were statistically significant. The other tested blood lipids in the experimental groups and the control group did not show a significant difference. Conclusion: It was found that consumption of Harmala seed can significantly reduce LDL cholesterol and the ethanolic extract of the herb is more effective than the aqueous one.http://journal.bums.ac.ir/browse.php?a_code=A-10-316-2&slc_lang=en&sid=1Key Words: Peganum harmala seed Triglyceride Cholesterol LDL Rat |
| spellingShingle | Mohammad Mehdi Hasanzadeh Tahery Mohammad Hasanpour Fard Navid Rabiee Sayed Amir Reza Ghoreishe Naeem Ravanbakhsh Effects of aqueous and ethanolic extracts of Peganum harmala L seeds on lipids profile in rats مجله دانشگاه علوم پزشکی بیرجند Key Words: Peganum harmala seed Triglyceride Cholesterol LDL Rat |
| title | Effects of aqueous and ethanolic extracts of Peganum harmala L seeds on lipids profile in rats |
| title_full | Effects of aqueous and ethanolic extracts of Peganum harmala L seeds on lipids profile in rats |
| title_fullStr | Effects of aqueous and ethanolic extracts of Peganum harmala L seeds on lipids profile in rats |
| title_full_unstemmed | Effects of aqueous and ethanolic extracts of Peganum harmala L seeds on lipids profile in rats |
| title_short | Effects of aqueous and ethanolic extracts of Peganum harmala L seeds on lipids profile in rats |
| title_sort | effects of aqueous and ethanolic extracts of peganum harmala l seeds on lipids profile in rats |
| topic | Key Words: Peganum harmala seed Triglyceride Cholesterol LDL Rat |
| url | http://journal.bums.ac.ir/browse.php?a_code=A-10-316-2&slc_lang=en&sid=1 |
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