Age-related histomorphometrical changes of rat's humerus
Previous research divided long bone growth into intramembranous and endochondral ossification. The latter contributes to longitudinal bone growth through the addition of new bone tissue at the physeal growth plate. Bones, also, increase in thickness through appositional bone growth of the cortical b...
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| Format: | Article |
| Language: | English |
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South Valley University
2023-06-01
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| Series: | SVU-International Journal of Veterinary Sciences |
| Subjects: | |
| Online Access: | https://svu.journals.ekb.eg/article_304083.html |
| _version_ | 1797799292162801664 |
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| author | Hussien Elkhateeb Elsayed S. I. Mohammed Dalia Mohamedien Yasser A. Ahmed Soha A. Soliman |
| author_facet | Hussien Elkhateeb Elsayed S. I. Mohammed Dalia Mohamedien Yasser A. Ahmed Soha A. Soliman |
| author_sort | Hussien Elkhateeb |
| collection | DOAJ |
| description | Previous research divided long bone growth into intramembranous and endochondral ossification. The latter contributes to longitudinal bone growth through the addition of new bone tissue at the physeal growth plate. Bones, also, increase in thickness through appositional bone growth of the cortical bone. The aim of the present study was to investigate the age-related histomorphometrical changes that occur during the growth of the humerus in rats as a model of the long bone. Samples were collected for light microscopy from the right humerus at 3, 4, 6, 8, 10, 13, and 20 weeks (wks) of age. Histological investigation revealed that the distal physeal growth plate could be detected at 3 wks of age, while at 4 wks of age it was replaced by bone trabeculae. Morphometrically, differences were observed in the thickness of the proximal physeal growth plate, specifically its proliferative zone. The thickness of the proliferative zone initially decreased, then showed a significant increase around the age of puberty (6–8 wks), then decreased significantly from 8–20 wks of age. The midshaft cortical bone thickness showed a significant increase during the study. In conclusion, ageing affected both longitudinal and appositional growth, which both participated in the growth and development of the rat's humerus. |
| first_indexed | 2024-03-13T04:17:44Z |
| format | Article |
| id | doaj.art-6c6740231b084bf8a6222ac322f307e4 |
| institution | Directory Open Access Journal |
| issn | 2535-1826 2535-1877 |
| language | English |
| last_indexed | 2024-03-13T04:17:44Z |
| publishDate | 2023-06-01 |
| publisher | South Valley University |
| record_format | Article |
| series | SVU-International Journal of Veterinary Sciences |
| spelling | doaj.art-6c6740231b084bf8a6222ac322f307e42023-06-20T20:45:29ZengSouth Valley UniversitySVU-International Journal of Veterinary Sciences2535-18262535-18772023-06-0162445410.21608/SVU.2023.188662.1254Age-related histomorphometrical changes of rat's humerusHussien Elkhateeb0Elsayed S. I. Mohammed1Dalia Mohamedien2Yasser A. Ahmed3Soha A. Soliman4Department of Histology, Faculty of Veterinary Medicine, South Valley University, Qena 83523, EgyptDepartment of Histology, Faculty of Veterinary Medicine, South Valley University, Qena 83523, EgyptDepartment of Histology, Faculty of Veterinary Medicine, South Valley University, Qena 83523, EgyptDepartment of Histology, Faculty of Veterinary Medicine, South Valley University, Qena 83523, EgyptDepartment of Histology, Faculty of Veterinary Medicine, South Valley University, Qena 83523, EgyptPrevious research divided long bone growth into intramembranous and endochondral ossification. The latter contributes to longitudinal bone growth through the addition of new bone tissue at the physeal growth plate. Bones, also, increase in thickness through appositional bone growth of the cortical bone. The aim of the present study was to investigate the age-related histomorphometrical changes that occur during the growth of the humerus in rats as a model of the long bone. Samples were collected for light microscopy from the right humerus at 3, 4, 6, 8, 10, 13, and 20 weeks (wks) of age. Histological investigation revealed that the distal physeal growth plate could be detected at 3 wks of age, while at 4 wks of age it was replaced by bone trabeculae. Morphometrically, differences were observed in the thickness of the proximal physeal growth plate, specifically its proliferative zone. The thickness of the proliferative zone initially decreased, then showed a significant increase around the age of puberty (6–8 wks), then decreased significantly from 8–20 wks of age. The midshaft cortical bone thickness showed a significant increase during the study. In conclusion, ageing affected both longitudinal and appositional growth, which both participated in the growth and development of the rat's humerus. https://svu.journals.ekb.eg/article_304083.htmlcortical bonegrowth platehypertrophic zonelong boneproliferating zone. |
| spellingShingle | Hussien Elkhateeb Elsayed S. I. Mohammed Dalia Mohamedien Yasser A. Ahmed Soha A. Soliman Age-related histomorphometrical changes of rat's humerus SVU-International Journal of Veterinary Sciences cortical bone growth plate hypertrophic zone long bone proliferating zone. |
| title | Age-related histomorphometrical changes of rat's humerus |
| title_full | Age-related histomorphometrical changes of rat's humerus |
| title_fullStr | Age-related histomorphometrical changes of rat's humerus |
| title_full_unstemmed | Age-related histomorphometrical changes of rat's humerus |
| title_short | Age-related histomorphometrical changes of rat's humerus |
| title_sort | age related histomorphometrical changes of rat s humerus |
| topic | cortical bone growth plate hypertrophic zone long bone proliferating zone. |
| url | https://svu.journals.ekb.eg/article_304083.html |
| work_keys_str_mv | AT hussienelkhateeb agerelatedhistomorphometricalchangesofratshumerus AT elsayedsimohammed agerelatedhistomorphometricalchangesofratshumerus AT daliamohamedien agerelatedhistomorphometricalchangesofratshumerus AT yasseraahmed agerelatedhistomorphometricalchangesofratshumerus AT sohaasoliman agerelatedhistomorphometricalchangesofratshumerus |