Experimental Models for Testing the Efficacy of Pharmacological Treatments for Neonatal Hypoxic-Ischemic Encephalopathy

Experimental Models for Testing the Efficacy of Pharmacological Treatments for Neonatal Hypoxic-Ischemic Encephalopathy

Representing an important cause of long–term disability, term neonatal hypoxic-ischemic encephalopathy (HIE) urgently needs further research aimed at repurposing existing drug as well as developing new therapeutics. Since various experimental in vitro and in vivo models of HIE have been developed wi...

Full description

Bibliographic Details
Main Authors:	Elisa Landucci, Domenico E. Pellegrini-Giampietro, Fabrizio Facchinetti
Format:	Article
Language:	English
Published:	MDPI AG 2022-04-01
Series:	Biomedicines
Subjects:	cerebral ischemia hypoxia oxygen and glucose deprivation cell cultures organotypic hippocampal slices neonate animal models
Online Access:	https://www.mdpi.com/2227-9059/10/5/937

Similar Items

Neuroprotective Effects of Thymoquinone by the Modulation of ER Stress and Apoptotic Pathway in In Vitro Model of Excitotoxicity
by: Elisa Landucci, et al.
Published: (2021-03-01)

Neuronal and Astrocytic Morphological Alterations Driven by Prolonged Exposure with Δ9-Tetrahydrocannabinol but Not Cannabidiol
by: Elisa Landucci, et al.
Published: (2022-01-01)

Neuritogenic and Neuroprotective Effects of Polar Steroids from the Far East Starfishes Patiria pectinifera and Distolasterias nipon
by: Valentin A. Stonik, et al.
Published: (2013-05-01)

Cannabidiol inhibits microglia activation and mitigates neuronal damage induced by kainate in an in-vitro seizure model
by: Elisa Landucci, et al.
Published: (2022-11-01)

Glutamate Receptor-Mediated Neurotoxicity in a Model of Ethanol Dependence and Withdrawal in Rat Organotypic Hippocampal Slice Cultures
by: Elisabetta Gerace, et al.
Published: (2019-01-01)

SNAP25 protects primary cortical neurons from hypoxic‐ischemic injury associated with CREB signal
by: Yuan Jin, et al.
Published: (2021-03-01)

Anti-inflammatory treatment in oxygen–glucose-deprived hippocampal slice cultures is neuroprotective and associated with reduced cell proliferation and intact neurogenesis
by: Olga Chechneva, et al.
Published: (2006-08-01)

Using of dexmedetomidine in term neonates with hypoxic-ischemic encephalopathy
by: D. Surkov
Published: (2019-11-01)

Is dexmedetomidine a potential neuroprotective agent for term neonates with hypoxic-ischemic encephalopathy?
by: D. Surkov
Published: (2019-01-01)

Association between glycemia and outcomes of neonates with hypoxic-ischemic encephalopathy: a systematic review and meta-analysis
by: Chen Wang, et al.
Published: (2024-11-01)

Therapeutic hypothermia for neonatal hypoxic-ischemic encephalopathy - where to from here?
by: Joanne O. Davidson, et al.
Published: (2015-09-01)

PARP-1 activation causes neuronal death in the hippocampal CA1 region by increasing the expression of Ca2+-permeable AMPA receptors
by: E. Gerace, et al.
Published: (2014-10-01)

Nanoparticle‐microglial interaction in the ischemic brain is modulated by injury duration and treatment
by: Andrea Joseph, et al.
Published: (2020-09-01)

Effects of Ischemia on the Migratory Capacity of Microglia Along Collagen Microcontact Prints on Organotypic Mouse Cortex Brain Slices
by: Katharina Steiner, et al.
Published: (2022-06-01)

Contribution of ginsenosides Rg1, Rb1 to the neuroprotective effect of Panax notoginseng in mouse organotypic hippocampal slice cultures exposed to oxygen and glucose deprivation
by: Nguyen Thi Thanh Loan, et al.
Published: (2022-03-01)

Effect of Clemastine on Neurophysiological Outcomes in an Ovine Model of Neonatal Hypoxic-Ischemic Encephalopathy
by: Jana Krystofova Mike, et al.
Published: (2023-10-01)

BID mediates oxygen-glucose deprivation-induced neuronal injury in organotypic hippocampal slice cultures and modulates tissue inflammation in a transient focal cerebral ischemia model without changing lesion volu
by: Nellie Anne Martin, et al.
Published: (2016-02-01)

Potential biomarkers for neuroinflammation and neurodegeneration at short and long term after neonatal hypoxic-ischemic insult in rat
by: Nozha Borjini, et al.
Published: (2019-10-01)

Combined Cyclosporin A and Hypothermia Treatment Inhibits Activation of BV-2 Microglia but Induces an Inflammatory Response in an Ischemia/Reperfusion Hippocampal Slice Culture Model
by: Sylvia J. Wowro, et al.
Published: (2019-06-01)

Formulation and Efficacy of Catalase-Loaded Nanoparticles for the Treatment of Neonatal Hypoxic-Ischemic Encephalopathy
by: Andrea Joseph, et al.
Published: (2021-07-01)

Use of ultraselective derivate of clonidine for prolonged sedation in term newborns with hypoxic-ischemic encephalopathy
by: D.M. Surkov
Published: (2019-12-01)

Oxygen-Glucose Deprivation in Organotypic Hippocampal Cultures Leads to Cytoskeleton Rearrangement and Immune Activation: Link to the Potential Pathomechanism of Ischaemic Stroke
by: Natalia Bryniarska-Kubiak, et al.
Published: (2023-05-01)

Neuroprotective function for ramified microglia in hippocampal excitotoxicity
by: Vinet Jonathan, et al.
Published: (2012-01-01)

Erythropoietin Reduces Death and Neurodevelopmental Impairment in Neonatal Hypoxic-Ischemic Encephalopathy
by: Seung Jun Bang, et al.
Published: (2022-11-01)

Language in Children with Neonatal Hypoxic-Ischemic Encephalopathy
by: Chenia Martinez, et al.
Published: (2014-02-01)

Neuroprotection by PGE2 receptor EP1 inhibition involves the PTEN/AKT pathway
by: Ping Zhou, et al.
Published: (2008-03-01)

HIF-1α inhibition ameliorates neonatal brain injury in a rat pup hypoxic–ischemic model
by: Wanqiu Chen, et al.
Published: (2008-09-01)

The role of G-CSF neuroprotective effects in neonatal hypoxic-ischemic encephalopathy (HIE): current status
by: John Sieh Dumbuya, et al.
Published: (2021-02-01)

Possible Role of Akt in Mossy Fiber Sprouting: Akt Activity and CA3 Mossy Fiber Sprouting in a Kainate Model of Epilepsy
by: Machlusil husna, et al.
Published: (2024-09-01)

Lipopolysaccharide-induced neuroinflammation induces presynaptic disruption through a direct action on brain tissue involving microglia-derived interleukin 1 beta
by: Olivia Sheppard, et al.
Published: (2019-05-01)

Pathophysiology of Cerebral Hyperperfusion in Term Neonates With Hypoxic-Ischemic Encephalopathy: A Systematic Review for Future Research
by: Dianne G. Kleuskens, et al.
Published: (2021-02-01)

The influence of exogenous recombinant HSP 70 on the alteration of membrane stiffness in hippocampal neurons following the modeling of neonatal hypoxic-ischemic injury in mice Authors
by: Vladimir M. Pokrovsky, et al.
Published: (2024-12-01)

A survey on the diagnosis and management of neonatal hypoxic ischaemic encephalopathy in sub-saharan Africa
by: H. E. Naburi, et al.
Published: (2024-09-01)

Leflunomide Treatment Does Not Protect Neural Cells following Oxygen-Glucose Deprivation (OGD) In Vitro
by: Claire J. M. Curel, et al.
Published: (2024-04-01)

Intramitochondrial Zn2+ accumulation via the Ca2+ uniporter contributes to acute ischemic neurodegeneration
by: Yuliya V. Medvedeva, et al.
Published: (2014-08-01)

Neurally Adjusted Ventilatory Assist Mode of Mechanical Ventilation in Neonates with Hypoxic-Ischemic Encephalopathy
by: D. M. Surkov
Published: (2019-05-01)

Predictive factors of death in neonates with hypoxic-ischemic encephalopathy receiving selective head cooling
by: Behnaz Basiri, et al.
Published: (2021-04-01)

Relaxin peptides reduce cellular damage in cultured brain slices exposed to transient oxygen–glucose deprivation: an effect mediated by nitric oxide
by: Nicholas P. DeAdder, et al.
Published: (2021-02-01)

Human cerebrospinal fluid promotes neuronal viability and activity of hippocampal neuronal circuits in vitro
by: Marta ePerez-Alcazar, et al.
Published: (2016-03-01)

The Effect of long-term rapamycin administration on intracellular calcium quantification and RhoA activity in kainic acid epilepsy model
by: Machlusil Husna, et al.
Published: (2025-01-01)