Intraperitoneal Paclitaxel Is Useful as Adjuvant Chemotherapy for Advanced Gastric Cancer with Serosal Exposure
Background: Intraperitoneal administration of paclitaxel (PTX) can elicit a marked clinical response in peritoneal metastases of gastric cancer. Methods: In this study, we retrospectively analyzed the clinical outcome of 17 patients who underwent R0 resection with D2 dissection for advanced gastric...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Karger Publishers
2014-01-01
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| Series: | Case Reports in Oncology |
| Subjects: | |
| Online Access: | http://www.karger.com/Article/FullText/358379 |
| _version_ | 1819049559956914176 |
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| author | Joji Kitayama Hironori Ishigami Hironori Yamaguchi Shigenobu Emoto Toshiaki Watanabe |
| author_facet | Joji Kitayama Hironori Ishigami Hironori Yamaguchi Shigenobu Emoto Toshiaki Watanabe |
| author_sort | Joji Kitayama |
| collection | DOAJ |
| description | Background: Intraperitoneal administration of paclitaxel (PTX) can elicit a marked clinical response in peritoneal metastases of gastric cancer. Methods: In this study, we retrospectively analyzed the clinical outcome of 17 patients who underwent R0 resection with D2 dissection for advanced gastric cancer with macroscopic serosal exposure and received intraperitoneal PTX as adjuvant therapy. Results: A pathological study revealed that the depth of invasion of the primary tumor was pT4a or pT4b in 10 cases, and that the pN stage was more than pN2 in 8 cases. Genetic analysis of peritoneal lavage fluid was performed in 14 cases, all of which were positive for carcinoembryonic antigen mRNA. In these patients, PTX was intraperitoneally administered at 20-60 mg/m2 with oral S-1 for 3-36 months after surgery. In a median follow-up period of 66 months, recurrence occurred in the liver and peritoneum in 2 (11.7%) and 1 (5.9%) patients, respectively, and no nodal recurrence was observed. Five-year overall survival and disease-free survival were 88.2 and 82.3%, respectively. Conclusion: Since these patients are considered to be a high-risk group for peritoneal recurrence, this result strongly suggests that adjuvant chemotherapy including intraperitoneal PTX is a promising protocol to improve the outcome of patients with advanced gastric cancer with serosal exposure. |
| first_indexed | 2024-12-21T11:34:05Z |
| format | Article |
| id | doaj.art-6c682d129fe4472abf28d68d4701c95d |
| institution | Directory Open Access Journal |
| issn | 1662-6575 |
| language | English |
| last_indexed | 2024-12-21T11:34:05Z |
| publishDate | 2014-01-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Oncology |
| spelling | doaj.art-6c682d129fe4472abf28d68d4701c95d2022-12-21T19:05:29ZengKarger PublishersCase Reports in Oncology1662-65752014-01-0171586410.1159/000358379358379Intraperitoneal Paclitaxel Is Useful as Adjuvant Chemotherapy for Advanced Gastric Cancer with Serosal ExposureJoji KitayamaHironori IshigamiHironori YamaguchiShigenobu EmotoToshiaki WatanabeBackground: Intraperitoneal administration of paclitaxel (PTX) can elicit a marked clinical response in peritoneal metastases of gastric cancer. Methods: In this study, we retrospectively analyzed the clinical outcome of 17 patients who underwent R0 resection with D2 dissection for advanced gastric cancer with macroscopic serosal exposure and received intraperitoneal PTX as adjuvant therapy. Results: A pathological study revealed that the depth of invasion of the primary tumor was pT4a or pT4b in 10 cases, and that the pN stage was more than pN2 in 8 cases. Genetic analysis of peritoneal lavage fluid was performed in 14 cases, all of which were positive for carcinoembryonic antigen mRNA. In these patients, PTX was intraperitoneally administered at 20-60 mg/m2 with oral S-1 for 3-36 months after surgery. In a median follow-up period of 66 months, recurrence occurred in the liver and peritoneum in 2 (11.7%) and 1 (5.9%) patients, respectively, and no nodal recurrence was observed. Five-year overall survival and disease-free survival were 88.2 and 82.3%, respectively. Conclusion: Since these patients are considered to be a high-risk group for peritoneal recurrence, this result strongly suggests that adjuvant chemotherapy including intraperitoneal PTX is a promising protocol to improve the outcome of patients with advanced gastric cancer with serosal exposure.http://www.karger.com/Article/FullText/358379Peritoneal recurrenceNodal recurrenceGastric cancerSerosal invasionIntraperitoneal chemotherapyPaclitaxel |
| spellingShingle | Joji Kitayama Hironori Ishigami Hironori Yamaguchi Shigenobu Emoto Toshiaki Watanabe Intraperitoneal Paclitaxel Is Useful as Adjuvant Chemotherapy for Advanced Gastric Cancer with Serosal Exposure Case Reports in Oncology Peritoneal recurrence Nodal recurrence Gastric cancer Serosal invasion Intraperitoneal chemotherapy Paclitaxel |
| title | Intraperitoneal Paclitaxel Is Useful as Adjuvant Chemotherapy for Advanced Gastric Cancer with Serosal Exposure |
| title_full | Intraperitoneal Paclitaxel Is Useful as Adjuvant Chemotherapy for Advanced Gastric Cancer with Serosal Exposure |
| title_fullStr | Intraperitoneal Paclitaxel Is Useful as Adjuvant Chemotherapy for Advanced Gastric Cancer with Serosal Exposure |
| title_full_unstemmed | Intraperitoneal Paclitaxel Is Useful as Adjuvant Chemotherapy for Advanced Gastric Cancer with Serosal Exposure |
| title_short | Intraperitoneal Paclitaxel Is Useful as Adjuvant Chemotherapy for Advanced Gastric Cancer with Serosal Exposure |
| title_sort | intraperitoneal paclitaxel is useful as adjuvant chemotherapy for advanced gastric cancer with serosal exposure |
| topic | Peritoneal recurrence Nodal recurrence Gastric cancer Serosal invasion Intraperitoneal chemotherapy Paclitaxel |
| url | http://www.karger.com/Article/FullText/358379 |
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