Inhibitor of DNA binding proteins revealed as orchestrators of steady state, stress and malignant hematopoiesis
Adult mammalian hematopoiesis is a dynamic cellular process that provides a continuous supply of myeloid, lymphoid, erythroid/megakaryocyte cells for host survival. This process is sustained by regulating hematopoietic stem cells (HSCs) quiescence, proliferation and activation under homeostasis and...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.934624/full |
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| author | Shweta Singh Tanmoy Sarkar Brad Jakubison Brad Jakubison Stephen Gadomski Andrew Spradlin Kristbjorn O. Gudmundsson Kristbjorn O. Gudmundsson Jonathan R. Keller Jonathan R. Keller |
| author_facet | Shweta Singh Tanmoy Sarkar Brad Jakubison Brad Jakubison Stephen Gadomski Andrew Spradlin Kristbjorn O. Gudmundsson Kristbjorn O. Gudmundsson Jonathan R. Keller Jonathan R. Keller |
| author_sort | Shweta Singh |
| collection | DOAJ |
| description | Adult mammalian hematopoiesis is a dynamic cellular process that provides a continuous supply of myeloid, lymphoid, erythroid/megakaryocyte cells for host survival. This process is sustained by regulating hematopoietic stem cells (HSCs) quiescence, proliferation and activation under homeostasis and stress, and regulating the proliferation and differentiation of downstream multipotent progenitor (MPP) and more committed progenitor cells. Inhibitor of DNA binding (ID) proteins are small helix-loop-helix (HLH) proteins that lack a basic (b) DNA binding domain present in other family members, and function as dominant-negative regulators of other bHLH proteins (E proteins) by inhibiting their transcriptional activity. ID proteins are required for normal T cell, B cell, NK and innate lymphoid cells, dendritic cell, and myeloid cell differentiation and development. However, recent evidence suggests that ID proteins are important regulators of normal and leukemic hematopoietic stem and progenitor cells (HSPCs). This chapter will review our current understanding of the function of ID proteins in HSPC development and highlight future areas of scientific investigation. |
| first_indexed | 2024-12-10T17:17:44Z |
| format | Article |
| id | doaj.art-6c698dcc8e404e2284a5a3cc0e3e0ba5 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-10T17:17:44Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-6c698dcc8e404e2284a5a3cc0e3e0ba52022-12-22T01:40:04ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-08-011310.3389/fimmu.2022.934624934624Inhibitor of DNA binding proteins revealed as orchestrators of steady state, stress and malignant hematopoiesisShweta Singh0Tanmoy Sarkar1Brad Jakubison2Brad Jakubison3Stephen Gadomski4Andrew Spradlin5Kristbjorn O. Gudmundsson6Kristbjorn O. Gudmundsson7Jonathan R. Keller8Jonathan R. Keller9Mouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute (NCI)- Frederick, Frederick, MD, United StatesMouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute (NCI)- Frederick, Frederick, MD, United StatesMouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute (NCI)- Frederick, Frederick, MD, United StatesBasic Science Program, Frederick National Laboratory for Cancer Research, Frederick, MD, United StatesMouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute (NCI)- Frederick, Frederick, MD, United StatesMouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute (NCI)- Frederick, Frederick, MD, United StatesMouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute (NCI)- Frederick, Frederick, MD, United StatesBasic Science Program, Frederick National Laboratory for Cancer Research, Frederick, MD, United StatesMouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute (NCI)- Frederick, Frederick, MD, United StatesBasic Science Program, Frederick National Laboratory for Cancer Research, Frederick, MD, United StatesAdult mammalian hematopoiesis is a dynamic cellular process that provides a continuous supply of myeloid, lymphoid, erythroid/megakaryocyte cells for host survival. This process is sustained by regulating hematopoietic stem cells (HSCs) quiescence, proliferation and activation under homeostasis and stress, and regulating the proliferation and differentiation of downstream multipotent progenitor (MPP) and more committed progenitor cells. Inhibitor of DNA binding (ID) proteins are small helix-loop-helix (HLH) proteins that lack a basic (b) DNA binding domain present in other family members, and function as dominant-negative regulators of other bHLH proteins (E proteins) by inhibiting their transcriptional activity. ID proteins are required for normal T cell, B cell, NK and innate lymphoid cells, dendritic cell, and myeloid cell differentiation and development. However, recent evidence suggests that ID proteins are important regulators of normal and leukemic hematopoietic stem and progenitor cells (HSPCs). This chapter will review our current understanding of the function of ID proteins in HSPC development and highlight future areas of scientific investigation.https://www.frontiersin.org/articles/10.3389/fimmu.2022.934624/fullID proteinshematopoiesisstem cellsquiescencestress |
| spellingShingle | Shweta Singh Tanmoy Sarkar Brad Jakubison Brad Jakubison Stephen Gadomski Andrew Spradlin Kristbjorn O. Gudmundsson Kristbjorn O. Gudmundsson Jonathan R. Keller Jonathan R. Keller Inhibitor of DNA binding proteins revealed as orchestrators of steady state, stress and malignant hematopoiesis Frontiers in Immunology ID proteins hematopoiesis stem cells quiescence stress |
| title | Inhibitor of DNA binding proteins revealed as orchestrators of steady state, stress and malignant hematopoiesis |
| title_full | Inhibitor of DNA binding proteins revealed as orchestrators of steady state, stress and malignant hematopoiesis |
| title_fullStr | Inhibitor of DNA binding proteins revealed as orchestrators of steady state, stress and malignant hematopoiesis |
| title_full_unstemmed | Inhibitor of DNA binding proteins revealed as orchestrators of steady state, stress and malignant hematopoiesis |
| title_short | Inhibitor of DNA binding proteins revealed as orchestrators of steady state, stress and malignant hematopoiesis |
| title_sort | inhibitor of dna binding proteins revealed as orchestrators of steady state stress and malignant hematopoiesis |
| topic | ID proteins hematopoiesis stem cells quiescence stress |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.934624/full |
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