Relationship of mTORC1 and ferroptosis in tumors
Abstract Ferroptosis is a novel form of programmed death, dependent on iron ions and oxidative stress, with a predominant intracellular form of lipid peroxidation. In recent years, ferroptosis has gained more and more interest of people in the treatment mechanism of targeted tumors. mTOR, always ove...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Springer
2024-04-01
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| Series: | Discover Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.1007/s12672-024-00954-w |
| _version_ | 1827291457436778496 |
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| author | Huilin Liao Yueqing Wang Lili Zou Yanmei Fan Xinyue Wang Xiancong Tu Qiaobai Zhu Jun Wang Xiaowen Liu Chuanjiang Dong |
| author_facet | Huilin Liao Yueqing Wang Lili Zou Yanmei Fan Xinyue Wang Xiancong Tu Qiaobai Zhu Jun Wang Xiaowen Liu Chuanjiang Dong |
| author_sort | Huilin Liao |
| collection | DOAJ |
| description | Abstract Ferroptosis is a novel form of programmed death, dependent on iron ions and oxidative stress, with a predominant intracellular form of lipid peroxidation. In recent years, ferroptosis has gained more and more interest of people in the treatment mechanism of targeted tumors. mTOR, always overexpressed in the tumor, and controlling cell growth and metabolic activities, has an important role in both autophagy and ferroptosis. Interestingly, the selective types of autophay plays an important role in promoting ferroptosis, which is related to mTOR and some metabolic pathways (especially in iron and amino acids). In this paper, we list the main mechanisms linking ferroptosis with mTOR signaling pathway and further summarize the current compounds targeting ferroptosis in these ways. There are growing experimental evidences that targeting mTOR and ferroptosis may have effective impact in many tumors, and understanding the mechanisms linking mTOR to ferroptosis could provide a potential therapeutic approach for tumor treatment. |
| first_indexed | 2024-04-24T12:38:25Z |
| format | Article |
| id | doaj.art-6c6acf7906594f57aaa49bbc19b7de2c |
| institution | Directory Open Access Journal |
| issn | 2730-6011 |
| language | English |
| last_indexed | 2024-04-24T12:38:25Z |
| publishDate | 2024-04-01 |
| publisher | Springer |
| record_format | Article |
| series | Discover Oncology |
| spelling | doaj.art-6c6acf7906594f57aaa49bbc19b7de2c2024-04-07T11:22:34ZengSpringerDiscover Oncology2730-60112024-04-0115111110.1007/s12672-024-00954-wRelationship of mTORC1 and ferroptosis in tumorsHuilin Liao0Yueqing Wang1Lili Zou2Yanmei Fan3Xinyue Wang4Xiancong Tu5Qiaobai Zhu6Jun Wang7Xiaowen Liu8Chuanjiang Dong9Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, College of Basic Medical Science, China Three Gorges UniversityHubei Key Laboratory of Tumor Microenvironment and Immunotherapy, College of Basic Medical Science, China Three Gorges UniversityHubei Key Laboratory of Tumor Microenvironment and Immunotherapy, College of Basic Medical Science, China Three Gorges UniversityHubei Key Laboratory of Tumor Microenvironment and Immunotherapy, College of Basic Medical Science, China Three Gorges UniversityHubei Key Laboratory of Tumor Microenvironment and Immunotherapy, College of Basic Medical Science, China Three Gorges UniversityHubei Key Laboratory of Tumor Microenvironment and Immunotherapy, College of Basic Medical Science, China Three Gorges UniversityHubei Key Laboratory of Tumor Microenvironment and Immunotherapy, College of Basic Medical Science, China Three Gorges UniversityThe People’s Hospital of China Three Gorges University and The First People’s Hospital of YichangHubei Key Laboratory of Tumor Microenvironment and Immunotherapy, College of Basic Medical Science, China Three Gorges UniversityDepartment of Urology, The First Dongguan Affiliated Hospital of Guangdong Medical UniversityAbstract Ferroptosis is a novel form of programmed death, dependent on iron ions and oxidative stress, with a predominant intracellular form of lipid peroxidation. In recent years, ferroptosis has gained more and more interest of people in the treatment mechanism of targeted tumors. mTOR, always overexpressed in the tumor, and controlling cell growth and metabolic activities, has an important role in both autophagy and ferroptosis. Interestingly, the selective types of autophay plays an important role in promoting ferroptosis, which is related to mTOR and some metabolic pathways (especially in iron and amino acids). In this paper, we list the main mechanisms linking ferroptosis with mTOR signaling pathway and further summarize the current compounds targeting ferroptosis in these ways. There are growing experimental evidences that targeting mTOR and ferroptosis may have effective impact in many tumors, and understanding the mechanisms linking mTOR to ferroptosis could provide a potential therapeutic approach for tumor treatment.https://doi.org/10.1007/s12672-024-00954-wFerroptosismTORAMPKAutophagyGPX4Tumors |
| spellingShingle | Huilin Liao Yueqing Wang Lili Zou Yanmei Fan Xinyue Wang Xiancong Tu Qiaobai Zhu Jun Wang Xiaowen Liu Chuanjiang Dong Relationship of mTORC1 and ferroptosis in tumors Discover Oncology Ferroptosis mTOR AMPK Autophagy GPX4 Tumors |
| title | Relationship of mTORC1 and ferroptosis in tumors |
| title_full | Relationship of mTORC1 and ferroptosis in tumors |
| title_fullStr | Relationship of mTORC1 and ferroptosis in tumors |
| title_full_unstemmed | Relationship of mTORC1 and ferroptosis in tumors |
| title_short | Relationship of mTORC1 and ferroptosis in tumors |
| title_sort | relationship of mtorc1 and ferroptosis in tumors |
| topic | Ferroptosis mTOR AMPK Autophagy GPX4 Tumors |
| url | https://doi.org/10.1007/s12672-024-00954-w |
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