cAMP-dependent regulation of HCN4 controls the tonic entrainment process in sinoatrial node pacemaker cells

cAMP-dependent regulation of HCN4 controls the tonic entrainment process in sinoatrial node pacemaker cells

The involvement of cAMP-dependent regulation of HCN4 in the chronotropic heart rate response is a matter of debate. Here the authors use a knockin mouse model expressing cAMP-insensitive HCN4 channels to discover an inhibitory nonfiring cell pool in the sinoatrial node and a tonic and mutual interac...

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Bibliographic Details
Main Authors: Stefanie Fenske, Konstantin Hennis, René D. Rötzer, Verena F. Brox, Elvir Becirovic, Andreas Scharr, Christian Gruner, Tilman Ziegler, Verena Mehlfeld, Jaclyn Brennan, Igor R. Efimov, Audrys G. Pauža, Markus Moser, Carsten T. Wotjak, Christian Kupatt, Rasmus Gönner, Rai Zhang, Henggui Zhang, Xiangang Zong, Martin Biel, Christian Wahl-Schott
Format: Article
Language:English
Published: Nature Portfolio 2020-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-19304-9

Internet

https://doi.org/10.1038/s41467-020-19304-9

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