A fatal case of recurrent amiodarone-induced thyrotoxicosis after percutaneous tracheotomy: a case report
<p>Abstract</p> <p>Background</p> <p>Amiodarone is a widely used antiarrythmic drug, which may produce secondary effects on the thyroid. In 14–18% of amiodarone-treated patients, there is overt thyroid dysfunction, usually in the form of amiodarone-induced thyrotoxicosi...
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| Format: | Article |
| Language: | English |
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BMC
2007-11-01
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| Series: | Journal of Medical Case Reports |
| Online Access: | http://www.jmedicalcasereports.com/content/1/1/134 |
| _version_ | 1818556005175263232 |
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| author | Papaioannou Vasilios Terzi Irene Dragoumanis Christos Konstantonis Dimitrios Theodorou Vassiliki Pneumatikos Ioannis |
| author_facet | Papaioannou Vasilios Terzi Irene Dragoumanis Christos Konstantonis Dimitrios Theodorou Vassiliki Pneumatikos Ioannis |
| author_sort | Papaioannou Vasilios |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Amiodarone is a widely used antiarrythmic drug, which may produce secondary effects on the thyroid. In 14–18% of amiodarone-treated patients, there is overt thyroid dysfunction, usually in the form of amiodarone-induced thyrotoxicosis, which can be difficult to manage with standard medical treatment.</p> <p>Case presentation</p> <p>Presented is the case of a 65-year-old man, under chronic treatment of atrial fibrillation with amiodarone, who was admitted to the Intensive Care Unit with acute cardio-respiratory failure and fever. He was recently hospitalized with respiratory distress, attributed to amiodarone-induced pulmonary fibrosis. Clinical and laboratory investigation revealed thyrotoxicosis due to amiodarone treatment. He was begun on thionamide, prednisone and beta-blockers. After a short term improvement of his clinical status the patient underwent percutaneous tracheotomy due to weaning failure from mechanical ventilation, which led to the development of recurrent thyrotoxicosis, unresponsive to medical treatment. Finally, the patient developed multiple organ failure and died, seven days later.</p> <p>Conclusion</p> <p>We suggest that percutaneous tracheotomy could precipitate a thyrotoxic crisis, particularly in non-euthyroid patients suffering from concurrent severe illness and should be performed only in parallel with emergency thyroid surgery, when indicated.</p> |
| first_indexed | 2024-12-13T23:41:52Z |
| format | Article |
| id | doaj.art-6c6b098cae8440a3b5156a93bdc36b26 |
| institution | Directory Open Access Journal |
| issn | 1752-1947 |
| language | English |
| last_indexed | 2024-12-13T23:41:52Z |
| publishDate | 2007-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Medical Case Reports |
| spelling | doaj.art-6c6b098cae8440a3b5156a93bdc36b262022-12-21T23:27:08ZengBMCJournal of Medical Case Reports1752-19472007-11-011113410.1186/1752-1947-1-134A fatal case of recurrent amiodarone-induced thyrotoxicosis after percutaneous tracheotomy: a case reportPapaioannou VasiliosTerzi IreneDragoumanis ChristosKonstantonis DimitriosTheodorou VassilikiPneumatikos Ioannis<p>Abstract</p> <p>Background</p> <p>Amiodarone is a widely used antiarrythmic drug, which may produce secondary effects on the thyroid. In 14–18% of amiodarone-treated patients, there is overt thyroid dysfunction, usually in the form of amiodarone-induced thyrotoxicosis, which can be difficult to manage with standard medical treatment.</p> <p>Case presentation</p> <p>Presented is the case of a 65-year-old man, under chronic treatment of atrial fibrillation with amiodarone, who was admitted to the Intensive Care Unit with acute cardio-respiratory failure and fever. He was recently hospitalized with respiratory distress, attributed to amiodarone-induced pulmonary fibrosis. Clinical and laboratory investigation revealed thyrotoxicosis due to amiodarone treatment. He was begun on thionamide, prednisone and beta-blockers. After a short term improvement of his clinical status the patient underwent percutaneous tracheotomy due to weaning failure from mechanical ventilation, which led to the development of recurrent thyrotoxicosis, unresponsive to medical treatment. Finally, the patient developed multiple organ failure and died, seven days later.</p> <p>Conclusion</p> <p>We suggest that percutaneous tracheotomy could precipitate a thyrotoxic crisis, particularly in non-euthyroid patients suffering from concurrent severe illness and should be performed only in parallel with emergency thyroid surgery, when indicated.</p>http://www.jmedicalcasereports.com/content/1/1/134 |
| spellingShingle | Papaioannou Vasilios Terzi Irene Dragoumanis Christos Konstantonis Dimitrios Theodorou Vassiliki Pneumatikos Ioannis A fatal case of recurrent amiodarone-induced thyrotoxicosis after percutaneous tracheotomy: a case report Journal of Medical Case Reports |
| title | A fatal case of recurrent amiodarone-induced thyrotoxicosis after percutaneous tracheotomy: a case report |
| title_full | A fatal case of recurrent amiodarone-induced thyrotoxicosis after percutaneous tracheotomy: a case report |
| title_fullStr | A fatal case of recurrent amiodarone-induced thyrotoxicosis after percutaneous tracheotomy: a case report |
| title_full_unstemmed | A fatal case of recurrent amiodarone-induced thyrotoxicosis after percutaneous tracheotomy: a case report |
| title_short | A fatal case of recurrent amiodarone-induced thyrotoxicosis after percutaneous tracheotomy: a case report |
| title_sort | fatal case of recurrent amiodarone induced thyrotoxicosis after percutaneous tracheotomy a case report |
| url | http://www.jmedicalcasereports.com/content/1/1/134 |
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