Altered cortical processing of sensory input in Huntington disease mouse models
Huntington disease (HD), a hereditary neurodegenerative disorder, manifests as progressively impaired movement and cognition. Although early abnormalities of neuronal activity in striatum are well established in HD models, there are fewer in vivo studies of the cortex. Here, we record local field po...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-07-01
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| Series: | Neurobiology of Disease |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0969996122001322 |
| _version_ | 1817986386011095040 |
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| author | Marja D. Sepers James P. Mackay Ellen Koch Dongsheng Xiao Majid H. Mohajerani Allen W. Chan Amy I. Smith-Dijak Daniel Ramandi Timothy H. Murphy Lynn A. Raymond |
| author_facet | Marja D. Sepers James P. Mackay Ellen Koch Dongsheng Xiao Majid H. Mohajerani Allen W. Chan Amy I. Smith-Dijak Daniel Ramandi Timothy H. Murphy Lynn A. Raymond |
| author_sort | Marja D. Sepers |
| collection | DOAJ |
| description | Huntington disease (HD), a hereditary neurodegenerative disorder, manifests as progressively impaired movement and cognition. Although early abnormalities of neuronal activity in striatum are well established in HD models, there are fewer in vivo studies of the cortex. Here, we record local field potentials (LFPs) in YAC128 HD model mice versus wild-type mice. In multiple cortical areas, limb sensory stimulation evokes a greater change in LFP power in YAC128 mice. Mesoscopic imaging using voltage-sensitive dyes reveals more extensive spread of evoked sensory signals across the cortical surface in YAC128 mice. YAC128 layer 2/3 sensory cortical neurons ex vivo show increased excitatory events, which could contribute to enhanced sensory responses in vivo. Cortical LFP responses to limb stimulation, visual and auditory input are also significantly increased in zQ175 HD mice. Results presented here extend knowledge of HD beyond ex vivo studies of individual neurons to the intact cortical network. |
| first_indexed | 2024-04-14T00:09:33Z |
| format | Article |
| id | doaj.art-6c6b2a489e66429e9fc1c4156edb5abf |
| institution | Directory Open Access Journal |
| issn | 1095-953X |
| language | English |
| last_indexed | 2024-04-14T00:09:33Z |
| publishDate | 2022-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neurobiology of Disease |
| spelling | doaj.art-6c6b2a489e66429e9fc1c4156edb5abf2022-12-22T02:23:24ZengElsevierNeurobiology of Disease1095-953X2022-07-01169105740Altered cortical processing of sensory input in Huntington disease mouse modelsMarja D. Sepers0James P. Mackay1Ellen Koch2Dongsheng Xiao3Majid H. Mohajerani4Allen W. Chan5Amy I. Smith-Dijak6Daniel Ramandi7Timothy H. Murphy8Lynn A. Raymond9Department of Psychiatry and Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC V6T1Z3, CanadaDepartment of Psychiatry and Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC V6T1Z3, CanadaDepartment of Psychiatry and Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC V6T1Z3, CanadaDepartment of Psychiatry and Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC V6T1Z3, CanadaCanadian Center for Behavioural Neuroscience, University of Lethbridge, Lethbridge T1K 3M4, CanadaDepartment of Psychiatry, University of Alberta, Edmonton, AB, CanadaDepartment of Psychiatry and Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC V6T1Z3, CanadaDepartment of Psychiatry and Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC V6T1Z3, CanadaDepartment of Psychiatry and Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC V6T1Z3, CanadaDepartment of Psychiatry and Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC V6T1Z3, Canada; Corresponding author at: Department of Psychiatry and Djavad Mowafaghian Centre for Brain Health, University of British Columbia, 2215 Wesbrook Mall, Vancouver, BC V6T1Z3, Canada.Huntington disease (HD), a hereditary neurodegenerative disorder, manifests as progressively impaired movement and cognition. Although early abnormalities of neuronal activity in striatum are well established in HD models, there are fewer in vivo studies of the cortex. Here, we record local field potentials (LFPs) in YAC128 HD model mice versus wild-type mice. In multiple cortical areas, limb sensory stimulation evokes a greater change in LFP power in YAC128 mice. Mesoscopic imaging using voltage-sensitive dyes reveals more extensive spread of evoked sensory signals across the cortical surface in YAC128 mice. YAC128 layer 2/3 sensory cortical neurons ex vivo show increased excitatory events, which could contribute to enhanced sensory responses in vivo. Cortical LFP responses to limb stimulation, visual and auditory input are also significantly increased in zQ175 HD mice. Results presented here extend knowledge of HD beyond ex vivo studies of individual neurons to the intact cortical network.http://www.sciencedirect.com/science/article/pii/S0969996122001322CortexHuntington diseaseMouse modelElectrophysiologyMesoscopic imagingIn vivo |
| spellingShingle | Marja D. Sepers James P. Mackay Ellen Koch Dongsheng Xiao Majid H. Mohajerani Allen W. Chan Amy I. Smith-Dijak Daniel Ramandi Timothy H. Murphy Lynn A. Raymond Altered cortical processing of sensory input in Huntington disease mouse models Neurobiology of Disease Cortex Huntington disease Mouse model Electrophysiology Mesoscopic imaging In vivo |
| title | Altered cortical processing of sensory input in Huntington disease mouse models |
| title_full | Altered cortical processing of sensory input in Huntington disease mouse models |
| title_fullStr | Altered cortical processing of sensory input in Huntington disease mouse models |
| title_full_unstemmed | Altered cortical processing of sensory input in Huntington disease mouse models |
| title_short | Altered cortical processing of sensory input in Huntington disease mouse models |
| title_sort | altered cortical processing of sensory input in huntington disease mouse models |
| topic | Cortex Huntington disease Mouse model Electrophysiology Mesoscopic imaging In vivo |
| url | http://www.sciencedirect.com/science/article/pii/S0969996122001322 |
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