Effects of Corilagin on Lipopolysaccharide-Induced Acute Lung Injury via Regulation of NADPH Oxidase 2 and ERK/NF-<i>κ</i>B Signaling Pathways in a Mouse Model
Acute lung injury (ALI) and acute respiratory distress syndrome are clinically life-threatening diseases. Corilagin, a major polyphenolic compound obtained from the herb <i>Phyllanthus urinaria</i>, has anti-inflammatory and antioxidant properties, and in this study, we sought to evaluat...
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MDPI AG
2022-07-01
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| Series: | Biology |
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| Online Access: | https://www.mdpi.com/2079-7737/11/7/1058 |
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| author | Fu-Chao Liu Chia-Chih Liao Hung-Chen Lee An-Hsun Chou Huang-Ping Yu |
| author_facet | Fu-Chao Liu Chia-Chih Liao Hung-Chen Lee An-Hsun Chou Huang-Ping Yu |
| author_sort | Fu-Chao Liu |
| collection | DOAJ |
| description | Acute lung injury (ALI) and acute respiratory distress syndrome are clinically life-threatening diseases. Corilagin, a major polyphenolic compound obtained from the herb <i>Phyllanthus urinaria</i>, has anti-inflammatory and antioxidant properties, and in this study, we sought to evaluate the protective effects and mechanisms of corilagin on lipopolysaccharide (LPS)-induced ALI in mice. ALI was induced in the mice by the intratracheal administration of LPS, and following 30 min of LPS challenge, corilagin (5 and 10 mg/kg body weight) was administered intraperitoneally. At 6 h post-LPS administration, lung tissues were collected for analysis. Corilagin treatment significantly attenuated inflammatory cell infiltration, the production of pro-inflammatory cytokines TNF-α, IL-6, and IL-1β, and oxidative stress in lung tissues. In addition, corilagin inhibited the LPS-induced expression of NOX2, ERK, and NF-<i>κ</i>B. Corilagin has anti-oxidative and anti-inflammatory effects, and can effectively reduce ALI via attenuation of the NOX2 and ERK/NF-<i>κ</i>B signaling pathways. |
| first_indexed | 2024-03-09T12:13:51Z |
| format | Article |
| id | doaj.art-6c6bd1592b6449fdb16f5d943491cc10 |
| institution | Directory Open Access Journal |
| issn | 2079-7737 |
| language | English |
| last_indexed | 2024-03-09T12:13:51Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biology |
| spelling | doaj.art-6c6bd1592b6449fdb16f5d943491cc102023-11-30T22:49:26ZengMDPI AGBiology2079-77372022-07-01117105810.3390/biology11071058Effects of Corilagin on Lipopolysaccharide-Induced Acute Lung Injury via Regulation of NADPH Oxidase 2 and ERK/NF-<i>κ</i>B Signaling Pathways in a Mouse ModelFu-Chao Liu0Chia-Chih Liao1Hung-Chen Lee2An-Hsun Chou3Huang-Ping Yu4Department of Anesthesiology, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan 333, TaiwanDepartment of Anesthesiology, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan 333, TaiwanDepartment of Anesthesiology, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan 333, TaiwanDepartment of Anesthesiology, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan 333, TaiwanDepartment of Anesthesiology, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan 333, TaiwanAcute lung injury (ALI) and acute respiratory distress syndrome are clinically life-threatening diseases. Corilagin, a major polyphenolic compound obtained from the herb <i>Phyllanthus urinaria</i>, has anti-inflammatory and antioxidant properties, and in this study, we sought to evaluate the protective effects and mechanisms of corilagin on lipopolysaccharide (LPS)-induced ALI in mice. ALI was induced in the mice by the intratracheal administration of LPS, and following 30 min of LPS challenge, corilagin (5 and 10 mg/kg body weight) was administered intraperitoneally. At 6 h post-LPS administration, lung tissues were collected for analysis. Corilagin treatment significantly attenuated inflammatory cell infiltration, the production of pro-inflammatory cytokines TNF-α, IL-6, and IL-1β, and oxidative stress in lung tissues. In addition, corilagin inhibited the LPS-induced expression of NOX2, ERK, and NF-<i>κ</i>B. Corilagin has anti-oxidative and anti-inflammatory effects, and can effectively reduce ALI via attenuation of the NOX2 and ERK/NF-<i>κ</i>B signaling pathways.https://www.mdpi.com/2079-7737/11/7/1058corilaginlipopolysaccharideacute lung injuryinflammationoxidative stressNOX2 |
| spellingShingle | Fu-Chao Liu Chia-Chih Liao Hung-Chen Lee An-Hsun Chou Huang-Ping Yu Effects of Corilagin on Lipopolysaccharide-Induced Acute Lung Injury via Regulation of NADPH Oxidase 2 and ERK/NF-<i>κ</i>B Signaling Pathways in a Mouse Model Biology corilagin lipopolysaccharide acute lung injury inflammation oxidative stress NOX2 |
| title | Effects of Corilagin on Lipopolysaccharide-Induced Acute Lung Injury via Regulation of NADPH Oxidase 2 and ERK/NF-<i>κ</i>B Signaling Pathways in a Mouse Model |
| title_full | Effects of Corilagin on Lipopolysaccharide-Induced Acute Lung Injury via Regulation of NADPH Oxidase 2 and ERK/NF-<i>κ</i>B Signaling Pathways in a Mouse Model |
| title_fullStr | Effects of Corilagin on Lipopolysaccharide-Induced Acute Lung Injury via Regulation of NADPH Oxidase 2 and ERK/NF-<i>κ</i>B Signaling Pathways in a Mouse Model |
| title_full_unstemmed | Effects of Corilagin on Lipopolysaccharide-Induced Acute Lung Injury via Regulation of NADPH Oxidase 2 and ERK/NF-<i>κ</i>B Signaling Pathways in a Mouse Model |
| title_short | Effects of Corilagin on Lipopolysaccharide-Induced Acute Lung Injury via Regulation of NADPH Oxidase 2 and ERK/NF-<i>κ</i>B Signaling Pathways in a Mouse Model |
| title_sort | effects of corilagin on lipopolysaccharide induced acute lung injury via regulation of nadph oxidase 2 and erk nf i κ i b signaling pathways in a mouse model |
| topic | corilagin lipopolysaccharide acute lung injury inflammation oxidative stress NOX2 |
| url | https://www.mdpi.com/2079-7737/11/7/1058 |
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