Histology of the Primary Tumor Correlates with False Positivity of Integrated 18F-FDG-PET/CT Lymph Node Staging in Resectable Lung Cancer Patients
This study aimed to evaluate the diagnostic accuracy and false positivity rate of lymph node (LN) staging assessed by integrated 18F-fluorodeoxyglucose positron emission computed tomography (18F-FDG-PET/CT) in patients with operable lung cancer to the tumor histology. In total, 129 consecutive patie...
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| Format: | Article |
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MDPI AG
2023-05-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/13/11/1893 |
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| author | Fuad Damirov Mircea Gabriel Stoleriu Farkhad Manapov Karen Büsing Julia Dorothea Michels Gerhard Preissler Rudolf A. Hatz Peter Hohenberger Eric D. Roessner |
| author_facet | Fuad Damirov Mircea Gabriel Stoleriu Farkhad Manapov Karen Büsing Julia Dorothea Michels Gerhard Preissler Rudolf A. Hatz Peter Hohenberger Eric D. Roessner |
| author_sort | Fuad Damirov |
| collection | DOAJ |
| description | This study aimed to evaluate the diagnostic accuracy and false positivity rate of lymph node (LN) staging assessed by integrated 18F-fluorodeoxyglucose positron emission computed tomography (18F-FDG-PET/CT) in patients with operable lung cancer to the tumor histology. In total, 129 consecutive patients with non-small-cell lung cancer (NSCLC) undergoing anatomical lung resections were included. Preoperative LN staging was evaluated in the relationship to the histology of the resected specimens (group 1: lung adenocarcinoma/LUAD; group 2: squamous cell carcinoma/SQCA). Statistical analysis was performed by the Mann–Whitney U-test, the chi<sup>2</sup> test, and binary logistic regression analysis. To establish an easy-to-use algorithm for the identification of LN false positivity, a decision tree including clinically meaningful parameters was generated. In total, 77 (59.7%) and 52 (40.3%) patients were included in the LUAD and SQCA groups, respectively. SQCA histology, non-G1 tumors, and tumor SUVmax > 12.65 were identified as independent predictors of LN false positivity in the preoperative staging. The corresponding ORs and their 95% CIs were 3.35 [1.10–10.22], <i>p</i> = 0.0339; 4.60 [1.06–19.94], <i>p</i> = 0.0412; and 2.76 [1.01–7.55], and <i>p</i> = 0.0483. The preoperative identification of false-positive LNs is an important aspect of the treatment regimen for patients with operable lung cancer; thus, these preliminary findings should be further evaluated in larger patient cohorts. |
| first_indexed | 2024-03-11T03:09:34Z |
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| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-11T03:09:34Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-6c6e4c3a1acd4db581c43c829ced9ee82023-11-18T07:42:32ZengMDPI AGDiagnostics2075-44182023-05-011311189310.3390/diagnostics13111893Histology of the Primary Tumor Correlates with False Positivity of Integrated 18F-FDG-PET/CT Lymph Node Staging in Resectable Lung Cancer PatientsFuad Damirov0Mircea Gabriel Stoleriu1Farkhad Manapov2Karen Büsing3Julia Dorothea Michels4Gerhard Preissler5Rudolf A. Hatz6Peter Hohenberger7Eric D. Roessner8Department of Thoracic Surgery, Ludwig Maximilian University of Munich, 81377 Munich, GermanyDepartment of Thoracic Surgery, Ludwig Maximilian University of Munich, 81377 Munich, GermanyInstitute for Lung Biology and Disease, Comprehensive Pneumology Center (CPC), Member of the German Lung Research Center (DZL), Helmholtz Zentrum München, 81377 Munich, GermanyClinic for Radiology and Nuclear Medicine, University Hospital Mannheim, University of Heidelberg, 68167 Mannheim, GermanyDepartment of Pulmonology and Critical Care, Thoraxklinik Heidelberg gGmbH, University of Heidelberg, 69126 Heidelberg, GermanyInstitute for Lung Biology and Disease, Comprehensive Pneumology Center (CPC), Member of the German Lung Research Center (DZL), Helmholtz Zentrum München, 81377 Munich, GermanyDepartment of Thoracic Surgery, Ludwig Maximilian University of Munich, 81377 Munich, GermanyDepartment of Surgery, Division of Surgical Oncology and Thoracic Surgery, University Hospital Mannheim, University of Heidelberg, 68167 Mannheim, GermanyDepartment of Surgery, Division of Surgical Oncology and Thoracic Surgery, University Hospital Mannheim, University of Heidelberg, 68167 Mannheim, GermanyThis study aimed to evaluate the diagnostic accuracy and false positivity rate of lymph node (LN) staging assessed by integrated 18F-fluorodeoxyglucose positron emission computed tomography (18F-FDG-PET/CT) in patients with operable lung cancer to the tumor histology. In total, 129 consecutive patients with non-small-cell lung cancer (NSCLC) undergoing anatomical lung resections were included. Preoperative LN staging was evaluated in the relationship to the histology of the resected specimens (group 1: lung adenocarcinoma/LUAD; group 2: squamous cell carcinoma/SQCA). Statistical analysis was performed by the Mann–Whitney U-test, the chi<sup>2</sup> test, and binary logistic regression analysis. To establish an easy-to-use algorithm for the identification of LN false positivity, a decision tree including clinically meaningful parameters was generated. In total, 77 (59.7%) and 52 (40.3%) patients were included in the LUAD and SQCA groups, respectively. SQCA histology, non-G1 tumors, and tumor SUVmax > 12.65 were identified as independent predictors of LN false positivity in the preoperative staging. The corresponding ORs and their 95% CIs were 3.35 [1.10–10.22], <i>p</i> = 0.0339; 4.60 [1.06–19.94], <i>p</i> = 0.0412; and 2.76 [1.01–7.55], and <i>p</i> = 0.0483. The preoperative identification of false-positive LNs is an important aspect of the treatment regimen for patients with operable lung cancer; thus, these preliminary findings should be further evaluated in larger patient cohorts.https://www.mdpi.com/2075-4418/13/11/1893lung cancer18F-FDG-PET/CTlymph node stagingfalse-positive lymph nodesdiagnostic accuracydecision tree |
| spellingShingle | Fuad Damirov Mircea Gabriel Stoleriu Farkhad Manapov Karen Büsing Julia Dorothea Michels Gerhard Preissler Rudolf A. Hatz Peter Hohenberger Eric D. Roessner Histology of the Primary Tumor Correlates with False Positivity of Integrated 18F-FDG-PET/CT Lymph Node Staging in Resectable Lung Cancer Patients Diagnostics lung cancer 18F-FDG-PET/CT lymph node staging false-positive lymph nodes diagnostic accuracy decision tree |
| title | Histology of the Primary Tumor Correlates with False Positivity of Integrated 18F-FDG-PET/CT Lymph Node Staging in Resectable Lung Cancer Patients |
| title_full | Histology of the Primary Tumor Correlates with False Positivity of Integrated 18F-FDG-PET/CT Lymph Node Staging in Resectable Lung Cancer Patients |
| title_fullStr | Histology of the Primary Tumor Correlates with False Positivity of Integrated 18F-FDG-PET/CT Lymph Node Staging in Resectable Lung Cancer Patients |
| title_full_unstemmed | Histology of the Primary Tumor Correlates with False Positivity of Integrated 18F-FDG-PET/CT Lymph Node Staging in Resectable Lung Cancer Patients |
| title_short | Histology of the Primary Tumor Correlates with False Positivity of Integrated 18F-FDG-PET/CT Lymph Node Staging in Resectable Lung Cancer Patients |
| title_sort | histology of the primary tumor correlates with false positivity of integrated 18f fdg pet ct lymph node staging in resectable lung cancer patients |
| topic | lung cancer 18F-FDG-PET/CT lymph node staging false-positive lymph nodes diagnostic accuracy decision tree |
| url | https://www.mdpi.com/2075-4418/13/11/1893 |
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