Proton Therapy and Gliomas: A Systematic Review
Background: Gliomas are primary cerebral tumors. Radiation therapy plays a key role in their treatment but with a risk of toxicity associated with the dose to and volume of normal tissue that is irradiated. With its precision properties allowing for the increased sparing of healthy tissue, proton th...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-09-01
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| Series: | Radiation |
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| Online Access: | https://www.mdpi.com/2673-592X/1/3/19 |
| _version_ | 1797517422878523392 |
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| author | Isabelle Chambrelant Jordan Eber Delphine Antoni Hélène Burckel Georges Noël Romane Auvergne |
| author_facet | Isabelle Chambrelant Jordan Eber Delphine Antoni Hélène Burckel Georges Noël Romane Auvergne |
| author_sort | Isabelle Chambrelant |
| collection | DOAJ |
| description | Background: Gliomas are primary cerebral tumors. Radiation therapy plays a key role in their treatment but with a risk of toxicity associated with the dose to and volume of normal tissue that is irradiated. With its precision properties allowing for the increased sparing of healthy tissue, proton therapy could be an interesting option for this pathology. Methods: Two reviewers performed a systematic review of original papers published between 2010 and July 2021 following PRISMA guidelines. We analyzed disease outcomes, toxicity outcomes, or dosimetry data in four separate groups: children/adults and individuals with low-/high-grade gliomas. Results: Among 15 studies, 11 concerned clinical and toxicity outcomes, and 4 reported dosimetry data. Proton therapy showed similar disease outcomes with greater tolerance than conventional radiation therapy, partly due to the better dosimetry plans. Conclusions: This review suggests that proton therapy is a promising technique for glioma treatment. However, studies with a high level of evidence are still needed to validate this finding. |
| first_indexed | 2024-03-10T07:16:25Z |
| format | Article |
| id | doaj.art-6c704de0b14e4a589950265ec46cf078 |
| institution | Directory Open Access Journal |
| issn | 2673-592X |
| language | English |
| last_indexed | 2024-03-10T07:16:25Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Radiation |
| spelling | doaj.art-6c704de0b14e4a589950265ec46cf0782023-11-22T15:02:25ZengMDPI AGRadiation2673-592X2021-09-011321823310.3390/radiation1030019Proton Therapy and Gliomas: A Systematic ReviewIsabelle Chambrelant0Jordan Eber1Delphine Antoni2Hélène Burckel3Georges Noël4Romane Auvergne5Paul Strauss Comprehensive Cancer Center, Institut de Cancérologie Strasbourg Europe (ICANS), Department of Radiation Oncology, Unicancer, 67200 Strasbourg, FrancePaul Strauss Comprehensive Cancer Center, Institut de Cancérologie Strasbourg Europe (ICANS), Department of Radiation Oncology, Unicancer, 67200 Strasbourg, FrancePaul Strauss Comprehensive Cancer Center, Institut de Cancérologie Strasbourg Europe (ICANS), Department of Radiation Oncology, Unicancer, 67200 Strasbourg, FrancePaul Strauss Comprehensive Cancer Center, Radiobiology Laboratory, Institut de Cancérologie Strasbourg Europe (ICANS), Strasbourg University, UNICANCER, 67000 Strasbourg, FrancePaul Strauss Comprehensive Cancer Center, Institut de Cancérologie Strasbourg Europe (ICANS), Department of Radiation Oncology, Unicancer, 67200 Strasbourg, FrancePaul Strauss Comprehensive Cancer Center, Radiobiology Laboratory, Institut de Cancérologie Strasbourg Europe (ICANS), Strasbourg University, UNICANCER, 67000 Strasbourg, FranceBackground: Gliomas are primary cerebral tumors. Radiation therapy plays a key role in their treatment but with a risk of toxicity associated with the dose to and volume of normal tissue that is irradiated. With its precision properties allowing for the increased sparing of healthy tissue, proton therapy could be an interesting option for this pathology. Methods: Two reviewers performed a systematic review of original papers published between 2010 and July 2021 following PRISMA guidelines. We analyzed disease outcomes, toxicity outcomes, or dosimetry data in four separate groups: children/adults and individuals with low-/high-grade gliomas. Results: Among 15 studies, 11 concerned clinical and toxicity outcomes, and 4 reported dosimetry data. Proton therapy showed similar disease outcomes with greater tolerance than conventional radiation therapy, partly due to the better dosimetry plans. Conclusions: This review suggests that proton therapy is a promising technique for glioma treatment. However, studies with a high level of evidence are still needed to validate this finding.https://www.mdpi.com/2673-592X/1/3/19proton therapygliomasbrain tumorsoutcomessystematic review |
| spellingShingle | Isabelle Chambrelant Jordan Eber Delphine Antoni Hélène Burckel Georges Noël Romane Auvergne Proton Therapy and Gliomas: A Systematic Review Radiation proton therapy gliomas brain tumors outcomes systematic review |
| title | Proton Therapy and Gliomas: A Systematic Review |
| title_full | Proton Therapy and Gliomas: A Systematic Review |
| title_fullStr | Proton Therapy and Gliomas: A Systematic Review |
| title_full_unstemmed | Proton Therapy and Gliomas: A Systematic Review |
| title_short | Proton Therapy and Gliomas: A Systematic Review |
| title_sort | proton therapy and gliomas a systematic review |
| topic | proton therapy gliomas brain tumors outcomes systematic review |
| url | https://www.mdpi.com/2673-592X/1/3/19 |
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