Effects of postweaning cadmium exposure on socioemotional behaviors in adolescent male mice
Exposure to cadmium (Cd), a toxic heavy metal classified as an environmental endocrine disruptor, can exert significant toxicity in both animals and humans. However, the potential effects of Cd exposure on socioemotional behaviors are still poorly understood, as are the underlying mechanisms. In the...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-03-01
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| Series: | Ecotoxicology and Environmental Safety |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651324001647 |
| _version_ | 1797300362451877888 |
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| author | Zhengxin Zhang Yuxin Li Hao Feng Shijun Li Zihan Qin Jiabo Li Yifei Chen Yue Zhang Ye Zhao Xueyong Yin Boya Huang Yuan Gao Yun Shi Haishui Shi |
| author_facet | Zhengxin Zhang Yuxin Li Hao Feng Shijun Li Zihan Qin Jiabo Li Yifei Chen Yue Zhang Ye Zhao Xueyong Yin Boya Huang Yuan Gao Yun Shi Haishui Shi |
| author_sort | Zhengxin Zhang |
| collection | DOAJ |
| description | Exposure to cadmium (Cd), a toxic heavy metal classified as an environmental endocrine disruptor, can exert significant toxicity in both animals and humans. However, the potential effects of Cd exposure on socioemotional behaviors are still poorly understood, as are the underlying mechanisms. In the present study, employing a series of behavioral tests as well as 16 S rRNA sequencing analysis, we investigated the long-term effects of Cd exposure on socioemotional behaviors and their associated mechanisms in mice based on the brain–gut interaction theory. The results showed that postweaning exposure to Cd reduced the ability to resist depression, decreased social interaction, subtly altered sexual preference, and changed the composition of the gut microbiota in male mice during adolescence. These findings provided direct evidence for the deleterious effects of exposure to Cd in the postweaning period on socioemotional behaviors later in adolescence, and suggested that these effects of Cd exposure may be linked to changes in the gut microbiota. |
| first_indexed | 2024-03-07T23:07:08Z |
| format | Article |
| id | doaj.art-6c706bb5508949c69bb87e3cabfe4bb8 |
| institution | Directory Open Access Journal |
| issn | 0147-6513 |
| language | English |
| last_indexed | 2024-03-07T23:07:08Z |
| publishDate | 2024-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj.art-6c706bb5508949c69bb87e3cabfe4bb82024-02-22T04:51:38ZengElsevierEcotoxicology and Environmental Safety0147-65132024-03-01272116089Effects of postweaning cadmium exposure on socioemotional behaviors in adolescent male miceZhengxin Zhang0Yuxin Li1Hao Feng2Shijun Li3Zihan Qin4Jiabo Li5Yifei Chen6Yue Zhang7Ye Zhao8Xueyong Yin9Boya Huang10Yuan Gao11Yun Shi12Haishui Shi13Neuroscience Research Center, Institute of Medical and Health Science of Hebei Medical University, Shijiazhuang 050017, ChinaNeuroscience Research Center, Institute of Medical and Health Science of Hebei Medical University, Shijiazhuang 050017, ChinaNeuroscience Research Center, Institute of Medical and Health Science of Hebei Medical University, Shijiazhuang 050017, ChinaNeuroscience Research Center, Institute of Medical and Health Science of Hebei Medical University, Shijiazhuang 050017, ChinaNeuroscience Research Center, Institute of Medical and Health Science of Hebei Medical University, Shijiazhuang 050017, ChinaNeuroscience Research Center, Institute of Medical and Health Science of Hebei Medical University, Shijiazhuang 050017, ChinaNeuroscience Research Center, Institute of Medical and Health Science of Hebei Medical University, Shijiazhuang 050017, ChinaNeuroscience Research Center, Institute of Medical and Health Science of Hebei Medical University, Shijiazhuang 050017, ChinaNeuroscience Research Center, Institute of Medical and Health Science of Hebei Medical University, Shijiazhuang 050017, China; Hebei Key Laboratory of Neurophysiology, Hebei Medical University, Shijiazhuang 050017, ChinaNeuroscience Research Center, Institute of Medical and Health Science of Hebei Medical University, Shijiazhuang 050017, China; Hebei Key Laboratory of Neurophysiology, Hebei Medical University, Shijiazhuang 050017, ChinaNeuroscience Research Center, Institute of Medical and Health Science of Hebei Medical University, Shijiazhuang 050017, China; Hebei Key Laboratory of Neurophysiology, Hebei Medical University, Shijiazhuang 050017, ChinaNeuroscience Research Center, Institute of Medical and Health Science of Hebei Medical University, Shijiazhuang 050017, China; Hebei Key Laboratory of Neurophysiology, Hebei Medical University, Shijiazhuang 050017, ChinaNeuroscience Research Center, Institute of Medical and Health Science of Hebei Medical University, Shijiazhuang 050017, China; Hebei Key Laboratory of Neurophysiology, Hebei Medical University, Shijiazhuang 050017, China; Correspondence to: Neuroscience Research Center, Institute of Medical and Health Science, Hebei Medical University, No.361, East Zhongshan Road, Shijiazhuang 050017, China.Neuroscience Research Center, Institute of Medical and Health Science of Hebei Medical University, Shijiazhuang 050017, China; Hebei Key Laboratory of Neurophysiology, Hebei Medical University, Shijiazhuang 050017, China; Nursing School, Hebei Medical University, Shijiazhuang 050031, China; Hebei Key Laboratory of Forensic Medicine, Hebei Province, Shijiazhuang 050017, China; Correspondence to: Nursing School, Hebei Medical University, No.48, Donggang Road, Shijiazhuang 050031, China.Exposure to cadmium (Cd), a toxic heavy metal classified as an environmental endocrine disruptor, can exert significant toxicity in both animals and humans. However, the potential effects of Cd exposure on socioemotional behaviors are still poorly understood, as are the underlying mechanisms. In the present study, employing a series of behavioral tests as well as 16 S rRNA sequencing analysis, we investigated the long-term effects of Cd exposure on socioemotional behaviors and their associated mechanisms in mice based on the brain–gut interaction theory. The results showed that postweaning exposure to Cd reduced the ability to resist depression, decreased social interaction, subtly altered sexual preference, and changed the composition of the gut microbiota in male mice during adolescence. These findings provided direct evidence for the deleterious effects of exposure to Cd in the postweaning period on socioemotional behaviors later in adolescence, and suggested that these effects of Cd exposure may be linked to changes in the gut microbiota.http://www.sciencedirect.com/science/article/pii/S0147651324001647CadmiumPostweaningSocioemotional behaviorGut microbiotaEnvironmental endocrine disruptorlong-term effects |
| spellingShingle | Zhengxin Zhang Yuxin Li Hao Feng Shijun Li Zihan Qin Jiabo Li Yifei Chen Yue Zhang Ye Zhao Xueyong Yin Boya Huang Yuan Gao Yun Shi Haishui Shi Effects of postweaning cadmium exposure on socioemotional behaviors in adolescent male mice Ecotoxicology and Environmental Safety Cadmium Postweaning Socioemotional behavior Gut microbiota Environmental endocrine disruptor long-term effects |
| title | Effects of postweaning cadmium exposure on socioemotional behaviors in adolescent male mice |
| title_full | Effects of postweaning cadmium exposure on socioemotional behaviors in adolescent male mice |
| title_fullStr | Effects of postweaning cadmium exposure on socioemotional behaviors in adolescent male mice |
| title_full_unstemmed | Effects of postweaning cadmium exposure on socioemotional behaviors in adolescent male mice |
| title_short | Effects of postweaning cadmium exposure on socioemotional behaviors in adolescent male mice |
| title_sort | effects of postweaning cadmium exposure on socioemotional behaviors in adolescent male mice |
| topic | Cadmium Postweaning Socioemotional behavior Gut microbiota Environmental endocrine disruptor long-term effects |
| url | http://www.sciencedirect.com/science/article/pii/S0147651324001647 |
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