Longitudinal amyloid and tau accumulation in autosomal dominant Alzheimer’s disease: findings from the Colombia-Boston (COLBOS) biomarker study
Abstract Background Neuroimaging studies of autosomal dominant Alzheimer’s disease (ADAD) enable characterization of the trajectories of cerebral amyloid-β (Aβ) and tau accumulation in the decades prior to clinical symptom onset. Longitudinal rates of regional tau accumulation measured with positron...
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| Format: | Article |
| Language: | English |
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BMC
2021-01-01
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| Series: | Alzheimer’s Research & Therapy |
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| Online Access: | https://doi.org/10.1186/s13195-020-00765-5 |
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| author | Justin S. Sanchez Bernard J. Hanseeuw Francisco Lopera Reisa A. Sperling Ana Baena Yamile Bocanegra David Aguillon Edmarie Guzmán-Vélez Enmanuelle Pardilla-Delgado Liliana Ramirez-Gomez Clara Vila-Castelar Jairo E. Martinez Joshua T. Fox-Fuller Claudia Ramos Martin Ochoa-Escudero Sergio Alvarez Heidi I. L. Jacobs Aaron P. Schultz Jennifer R. Gatchel J. Alex Becker Samantha R. Katz Danielle V. Mayblyum Julie C. Price Eric M. Reiman Keith A. Johnson Yakeel T. Quiroz |
| author_facet | Justin S. Sanchez Bernard J. Hanseeuw Francisco Lopera Reisa A. Sperling Ana Baena Yamile Bocanegra David Aguillon Edmarie Guzmán-Vélez Enmanuelle Pardilla-Delgado Liliana Ramirez-Gomez Clara Vila-Castelar Jairo E. Martinez Joshua T. Fox-Fuller Claudia Ramos Martin Ochoa-Escudero Sergio Alvarez Heidi I. L. Jacobs Aaron P. Schultz Jennifer R. Gatchel J. Alex Becker Samantha R. Katz Danielle V. Mayblyum Julie C. Price Eric M. Reiman Keith A. Johnson Yakeel T. Quiroz |
| author_sort | Justin S. Sanchez |
| collection | DOAJ |
| description | Abstract Background Neuroimaging studies of autosomal dominant Alzheimer’s disease (ADAD) enable characterization of the trajectories of cerebral amyloid-β (Aβ) and tau accumulation in the decades prior to clinical symptom onset. Longitudinal rates of regional tau accumulation measured with positron emission tomography (PET) and their relationship with other biomarker and cognitive changes remain to be fully characterized in ADAD. Methods Fourteen ADAD mutation carriers (Presenilin-1 E280A) and 15 age-matched non-carriers from the Colombian kindred underwent 2–3 sessions of Aβ (11C-Pittsburgh compound B) and tau (18F-flortaucipir) PET, structural magnetic resonance imaging, and neuropsychological evaluation over a 2–4-year follow-up period. Annualized rates of change for imaging and cognitive variables were compared between carriers and non-carriers, and relationships among baseline measurements and rates of change were assessed within carriers. Results Longitudinal measurements were consistent with a sequence of ADAD-related changes beginning with Aβ accumulation (16 years prior to expected symptom onset, EYO), followed by entorhinal cortex (EC) tau (9 EYO), neocortical tau (6 EYO), hippocampal atrophy (6 EYO), and cognitive decline (4 EYO). Rates of tau accumulation among carriers were most rapid in parietal neocortex (~ 9%/year). EC tau PET signal at baseline was a significant predictor of subsequent neocortical tau accumulation and cognitive decline within carriers. Conclusions Our results are consistent with the sequence of biological changes in ADAD implied by cross-sectional studies and highlight the importance of EC tau as an early biomarker and a potential link between Aβ burden and neocortical tau accumulation in ADAD. |
| first_indexed | 2024-12-20T11:41:39Z |
| format | Article |
| id | doaj.art-6c7078c506f2419da4f7a232e1dfe210 |
| institution | Directory Open Access Journal |
| issn | 1758-9193 |
| language | English |
| last_indexed | 2024-12-20T11:41:39Z |
| publishDate | 2021-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Alzheimer’s Research & Therapy |
| spelling | doaj.art-6c7078c506f2419da4f7a232e1dfe2102022-12-21T19:42:00ZengBMCAlzheimer’s Research & Therapy1758-91932021-01-0113111410.1186/s13195-020-00765-5Longitudinal amyloid and tau accumulation in autosomal dominant Alzheimer’s disease: findings from the Colombia-Boston (COLBOS) biomarker studyJustin S. Sanchez0Bernard J. Hanseeuw1Francisco Lopera2Reisa A. Sperling3Ana Baena4Yamile Bocanegra5David Aguillon6Edmarie Guzmán-Vélez7Enmanuelle Pardilla-Delgado8Liliana Ramirez-Gomez9Clara Vila-Castelar10Jairo E. Martinez11Joshua T. Fox-Fuller12Claudia Ramos13Martin Ochoa-Escudero14Sergio Alvarez15Heidi I. L. Jacobs16Aaron P. Schultz17Jennifer R. Gatchel18J. Alex Becker19Samantha R. Katz20Danielle V. Mayblyum21Julie C. Price22Eric M. Reiman23Keith A. Johnson24Yakeel T. Quiroz25Massachusetts General Hoospital, Harvard Medical SchoolMassachusetts General Hoospital, Harvard Medical SchoolGrupo de Neurociencias de Antioquia, Universidad de AntioquiaMassachusetts General Hoospital, Harvard Medical SchoolGrupo de Neurociencias de Antioquia, Universidad de AntioquiaGrupo de Neurociencias de Antioquia, Universidad de AntioquiaGrupo de Neurociencias de Antioquia, Universidad de AntioquiaMassachusetts General Hoospital, Harvard Medical SchoolMassachusetts General Hoospital, Harvard Medical SchoolMassachusetts General Hoospital, Harvard Medical SchoolMassachusetts General Hoospital, Harvard Medical SchoolMassachusetts General Hoospital, Harvard Medical SchoolMassachusetts General Hoospital, Harvard Medical SchoolGrupo de Neurociencias de Antioquia, Universidad de AntioquiaHospital Pablo Tobón UribeHospital Pablo Tobón UribeMassachusetts General Hoospital, Harvard Medical SchoolMassachusetts General Hoospital, Harvard Medical SchoolMassachusetts General Hoospital, Harvard Medical SchoolMassachusetts General Hoospital, Harvard Medical SchoolMassachusetts General Hoospital, Harvard Medical SchoolMassachusetts General Hoospital, Harvard Medical SchoolMassachusetts General Hoospital, Harvard Medical SchoolBanner Alzheimer’s InstituteMassachusetts General Hoospital, Harvard Medical SchoolMassachusetts General Hoospital, Harvard Medical SchoolAbstract Background Neuroimaging studies of autosomal dominant Alzheimer’s disease (ADAD) enable characterization of the trajectories of cerebral amyloid-β (Aβ) and tau accumulation in the decades prior to clinical symptom onset. Longitudinal rates of regional tau accumulation measured with positron emission tomography (PET) and their relationship with other biomarker and cognitive changes remain to be fully characterized in ADAD. Methods Fourteen ADAD mutation carriers (Presenilin-1 E280A) and 15 age-matched non-carriers from the Colombian kindred underwent 2–3 sessions of Aβ (11C-Pittsburgh compound B) and tau (18F-flortaucipir) PET, structural magnetic resonance imaging, and neuropsychological evaluation over a 2–4-year follow-up period. Annualized rates of change for imaging and cognitive variables were compared between carriers and non-carriers, and relationships among baseline measurements and rates of change were assessed within carriers. Results Longitudinal measurements were consistent with a sequence of ADAD-related changes beginning with Aβ accumulation (16 years prior to expected symptom onset, EYO), followed by entorhinal cortex (EC) tau (9 EYO), neocortical tau (6 EYO), hippocampal atrophy (6 EYO), and cognitive decline (4 EYO). Rates of tau accumulation among carriers were most rapid in parietal neocortex (~ 9%/year). EC tau PET signal at baseline was a significant predictor of subsequent neocortical tau accumulation and cognitive decline within carriers. Conclusions Our results are consistent with the sequence of biological changes in ADAD implied by cross-sectional studies and highlight the importance of EC tau as an early biomarker and a potential link between Aβ burden and neocortical tau accumulation in ADAD.https://doi.org/10.1186/s13195-020-00765-5Alzheimer’sTauAmyloidImagingLongitudinalAutosomal-Dominant |
| spellingShingle | Justin S. Sanchez Bernard J. Hanseeuw Francisco Lopera Reisa A. Sperling Ana Baena Yamile Bocanegra David Aguillon Edmarie Guzmán-Vélez Enmanuelle Pardilla-Delgado Liliana Ramirez-Gomez Clara Vila-Castelar Jairo E. Martinez Joshua T. Fox-Fuller Claudia Ramos Martin Ochoa-Escudero Sergio Alvarez Heidi I. L. Jacobs Aaron P. Schultz Jennifer R. Gatchel J. Alex Becker Samantha R. Katz Danielle V. Mayblyum Julie C. Price Eric M. Reiman Keith A. Johnson Yakeel T. Quiroz Longitudinal amyloid and tau accumulation in autosomal dominant Alzheimer’s disease: findings from the Colombia-Boston (COLBOS) biomarker study Alzheimer’s Research & Therapy Alzheimer’s Tau Amyloid Imaging Longitudinal Autosomal-Dominant |
| title | Longitudinal amyloid and tau accumulation in autosomal dominant Alzheimer’s disease: findings from the Colombia-Boston (COLBOS) biomarker study |
| title_full | Longitudinal amyloid and tau accumulation in autosomal dominant Alzheimer’s disease: findings from the Colombia-Boston (COLBOS) biomarker study |
| title_fullStr | Longitudinal amyloid and tau accumulation in autosomal dominant Alzheimer’s disease: findings from the Colombia-Boston (COLBOS) biomarker study |
| title_full_unstemmed | Longitudinal amyloid and tau accumulation in autosomal dominant Alzheimer’s disease: findings from the Colombia-Boston (COLBOS) biomarker study |
| title_short | Longitudinal amyloid and tau accumulation in autosomal dominant Alzheimer’s disease: findings from the Colombia-Boston (COLBOS) biomarker study |
| title_sort | longitudinal amyloid and tau accumulation in autosomal dominant alzheimer s disease findings from the colombia boston colbos biomarker study |
| topic | Alzheimer’s Tau Amyloid Imaging Longitudinal Autosomal-Dominant |
| url | https://doi.org/10.1186/s13195-020-00765-5 |
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