Combined pioglitazone–metformin and clomiphene citrate versus metformin and clomiphene citrate in induction of ovulation in women with clomiphene citrate-resistant polycystic ovary syndrome
Objective: To compare the efficacy of pioglitazone + metformin and clomiphene citrate (CC) with metformin and CC in women with CC-resistant polycystic ovary syndrome (PCOS). Design: Randomized clinical trial (RCT). Setting: A university teaching hospital in Cairo, Egypt. Patients: One hundred women...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2014-03-01
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| Series: | Middle East Fertility Society Journal |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1110569013000757 |
| _version_ | 1819112184439898112 |
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| author | Ghada Abdel Fattah Maged Al Mohammady Dalia Ahmed Hamed |
| author_facet | Ghada Abdel Fattah Maged Al Mohammady Dalia Ahmed Hamed |
| author_sort | Ghada Abdel Fattah |
| collection | DOAJ |
| description | Objective: To compare the efficacy of pioglitazone + metformin and clomiphene citrate (CC) with metformin and CC in women with CC-resistant polycystic ovary syndrome (PCOS).
Design: Randomized clinical trial (RCT).
Setting: A university teaching hospital in Cairo, Egypt.
Patients: One hundred women with CC-resistant PCOS.
Methods: Fifty women received pioglitazone 15 mg + metformin 850 mg once daily from the first day of the cycle for 10 days, and 50 women received metformin (500 mg three times daily). Clomiphene citrate 100 mg from the third day of the cycle for 5 days was added to each group. Treatment was continued for three cycles.
Main outcome measure(s): Ovulation rate and pregnancy rate.
Results: Ovulation rate was significantly higher in the pioglitazone + metformin and CC group than the metformin and CC group (69.8% versus 48.8%) (p: 0.002). Significantly higher serum E2 on day 12 and thicker endometrium were found in the pioglitazone + metformin and CC group in the three follow up cycles. Also, cummulative pregnancy rate was significantly higher in the pioglitazone + metformin and CC group than the metformin and CC group (58% versus 34%) (P: 0.027).
Conclusion: The use of pioglitazone/metformin and CC is more effective than metformin and CC as regards ovulation and pregnancy rates in anovulatory women with CC-resistant PCOS. |
| first_indexed | 2024-12-22T04:09:28Z |
| format | Article |
| id | doaj.art-6c71fec40e28451ab07d4e126816ae9b |
| institution | Directory Open Access Journal |
| issn | 1110-5690 |
| language | English |
| last_indexed | 2024-12-22T04:09:28Z |
| publishDate | 2014-03-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Middle East Fertility Society Journal |
| spelling | doaj.art-6c71fec40e28451ab07d4e126816ae9b2022-12-21T18:39:33ZengSpringerOpenMiddle East Fertility Society Journal1110-56902014-03-01191273310.1016/j.mefs.2013.05.003Combined pioglitazone–metformin and clomiphene citrate versus metformin and clomiphene citrate in induction of ovulation in women with clomiphene citrate-resistant polycystic ovary syndromeGhada Abdel Fattah0Maged Al Mohammady1Dalia Ahmed Hamed2Department of Obstetrics and Gynecology, Faculty of Medicine, Cairo University, EgyptDepartment of Obstetrics and Gynecology, Faculty of Medicine, Cairo University, EgyptChemical Pathology Department, Faculty of Medicine, Cairo University, EgyptObjective: To compare the efficacy of pioglitazone + metformin and clomiphene citrate (CC) with metformin and CC in women with CC-resistant polycystic ovary syndrome (PCOS). Design: Randomized clinical trial (RCT). Setting: A university teaching hospital in Cairo, Egypt. Patients: One hundred women with CC-resistant PCOS. Methods: Fifty women received pioglitazone 15 mg + metformin 850 mg once daily from the first day of the cycle for 10 days, and 50 women received metformin (500 mg three times daily). Clomiphene citrate 100 mg from the third day of the cycle for 5 days was added to each group. Treatment was continued for three cycles. Main outcome measure(s): Ovulation rate and pregnancy rate. Results: Ovulation rate was significantly higher in the pioglitazone + metformin and CC group than the metformin and CC group (69.8% versus 48.8%) (p: 0.002). Significantly higher serum E2 on day 12 and thicker endometrium were found in the pioglitazone + metformin and CC group in the three follow up cycles. Also, cummulative pregnancy rate was significantly higher in the pioglitazone + metformin and CC group than the metformin and CC group (58% versus 34%) (P: 0.027). Conclusion: The use of pioglitazone/metformin and CC is more effective than metformin and CC as regards ovulation and pregnancy rates in anovulatory women with CC-resistant PCOS.http://www.sciencedirect.com/science/article/pii/S1110569013000757PioglitazoneMetforminClomiphene citratrePCOS |
| spellingShingle | Ghada Abdel Fattah Maged Al Mohammady Dalia Ahmed Hamed Combined pioglitazone–metformin and clomiphene citrate versus metformin and clomiphene citrate in induction of ovulation in women with clomiphene citrate-resistant polycystic ovary syndrome Middle East Fertility Society Journal Pioglitazone Metformin Clomiphene citratre PCOS |
| title | Combined pioglitazone–metformin and clomiphene citrate versus metformin and clomiphene citrate in induction of ovulation in women with clomiphene citrate-resistant polycystic ovary syndrome |
| title_full | Combined pioglitazone–metformin and clomiphene citrate versus metformin and clomiphene citrate in induction of ovulation in women with clomiphene citrate-resistant polycystic ovary syndrome |
| title_fullStr | Combined pioglitazone–metformin and clomiphene citrate versus metformin and clomiphene citrate in induction of ovulation in women with clomiphene citrate-resistant polycystic ovary syndrome |
| title_full_unstemmed | Combined pioglitazone–metformin and clomiphene citrate versus metformin and clomiphene citrate in induction of ovulation in women with clomiphene citrate-resistant polycystic ovary syndrome |
| title_short | Combined pioglitazone–metformin and clomiphene citrate versus metformin and clomiphene citrate in induction of ovulation in women with clomiphene citrate-resistant polycystic ovary syndrome |
| title_sort | combined pioglitazone metformin and clomiphene citrate versus metformin and clomiphene citrate in induction of ovulation in women with clomiphene citrate resistant polycystic ovary syndrome |
| topic | Pioglitazone Metformin Clomiphene citratre PCOS |
| url | http://www.sciencedirect.com/science/article/pii/S1110569013000757 |
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