Comparative efficacy of chloroquine and pyrimethamine-sulfadoxine versus artemether and pyrimethamine-sulfadoxine in the treatment of uncomplicated falciparum malaria in children
Background Large amount of data show that chloroquine and pyrimethamine-sulfadoxine (PS) as standard drugs for falciparum malaria cause resistance; for that reason new drugs or combina- tion drugs are urgently needed. Artemether is one of the new drugs. It has been studied extensively in China and S...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Indonesian Pediatric Society Publishing House
2016-10-01
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| Series: | Paediatrica Indonesiana |
| Subjects: | |
| Online Access: | https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/783 |
| _version_ | 1819068808429568000 |
|---|---|
| author | Femmy Tambajong Tonny H Rampengan |
| author_facet | Femmy Tambajong Tonny H Rampengan |
| author_sort | Femmy Tambajong |
| collection | DOAJ |
| description | Background Large amount of data show that chloroquine and
pyrimethamine-sulfadoxine (PS) as standard drugs for falciparum
malaria cause resistance; for that reason new drugs or combina-
tion drugs are urgently needed. Artemether is one of the new
drugs. It has been studied extensively in China and Southeast
Asia during the past 10 years. The effectiveness of this drug in
clearing parasites has been thoroughly documented.
Objective The objective of this study was to investigate the
efficacy of the combination of chloroquine and PS compared to
artemether and PS in the treatment of uncomplicated falciparum
malaria.
Methods We did a single-blind randomized study on 60 children
with uncomplicated falciparum malaria. Thirty children were
treated with chloroquine (10 mg/kg for 2 days, then 5 mg/kg in
the 3 rd day) and PS (pyrimethamine 1-1.5 mg/kg single dose on
the 1 st day) and the other 30 children were treated with artemether
(4 mg/kg/day for 3 days) and PS. All patients were admitted to
hospital for at least 7 days.
Results Fever clearance time was significantly shorter in the group
that received artemether and PS compared to that in the chloro-
quine-and-PS group (42 hours vs. 75 hours 50 minutes, p<0.0001).
Parasite clearance time was significantly different between the
group that received artemether and PS and the chloroquine-and-
PS group (2.5 days vs. 3.1 days, p=0.04). The cure rate in the
chloroquine-and-PS group was 28/30 and that of the artemether-
and-PS group was 30/30. Nausea and vomiting were found in 1
patient treated with chloroquine and PS.
Conclusion The combined treatment of artemether and PS was
well tolerated. No adverse reactions attributable to the treatment
were noted |
| first_indexed | 2024-12-21T16:40:02Z |
| format | Article |
| id | doaj.art-6c7434d4b92740f190bdac91192b673d |
| institution | Directory Open Access Journal |
| issn | 0030-9311 2338-476X |
| language | English |
| last_indexed | 2024-12-21T16:40:02Z |
| publishDate | 2016-10-01 |
| publisher | Indonesian Pediatric Society Publishing House |
| record_format | Article |
| series | Paediatrica Indonesiana |
| spelling | doaj.art-6c7434d4b92740f190bdac91192b673d2022-12-21T18:57:07ZengIndonesian Pediatric Society Publishing HousePaediatrica Indonesiana0030-93112338-476X2016-10-014462283310.14238/pi44.6.2004.228-33646Comparative efficacy of chloroquine and pyrimethamine-sulfadoxine versus artemether and pyrimethamine-sulfadoxine in the treatment of uncomplicated falciparum malaria in childrenFemmy TambajongTonny H RampenganBackground Large amount of data show that chloroquine and pyrimethamine-sulfadoxine (PS) as standard drugs for falciparum malaria cause resistance; for that reason new drugs or combina- tion drugs are urgently needed. Artemether is one of the new drugs. It has been studied extensively in China and Southeast Asia during the past 10 years. The effectiveness of this drug in clearing parasites has been thoroughly documented. Objective The objective of this study was to investigate the efficacy of the combination of chloroquine and PS compared to artemether and PS in the treatment of uncomplicated falciparum malaria. Methods We did a single-blind randomized study on 60 children with uncomplicated falciparum malaria. Thirty children were treated with chloroquine (10 mg/kg for 2 days, then 5 mg/kg in the 3 rd day) and PS (pyrimethamine 1-1.5 mg/kg single dose on the 1 st day) and the other 30 children were treated with artemether (4 mg/kg/day for 3 days) and PS. All patients were admitted to hospital for at least 7 days. Results Fever clearance time was significantly shorter in the group that received artemether and PS compared to that in the chloro- quine-and-PS group (42 hours vs. 75 hours 50 minutes, p<0.0001). Parasite clearance time was significantly different between the group that received artemether and PS and the chloroquine-and- PS group (2.5 days vs. 3.1 days, p=0.04). The cure rate in the chloroquine-and-PS group was 28/30 and that of the artemether- and-PS group was 30/30. Nausea and vomiting were found in 1 patient treated with chloroquine and PS. Conclusion The combined treatment of artemether and PS was well tolerated. No adverse reactions attributable to the treatment were notedhttps://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/783chloroquinepyrimethamine-sulfadoxineartemetherfever clearance timeparasite clearance timefalciparum malaria |
| spellingShingle | Femmy Tambajong Tonny H Rampengan Comparative efficacy of chloroquine and pyrimethamine-sulfadoxine versus artemether and pyrimethamine-sulfadoxine in the treatment of uncomplicated falciparum malaria in children Paediatrica Indonesiana chloroquine pyrimethamine-sulfadoxine artemether fever clearance time parasite clearance time falciparum malaria |
| title | Comparative efficacy of chloroquine and pyrimethamine-sulfadoxine versus artemether and pyrimethamine-sulfadoxine in the treatment of uncomplicated falciparum malaria in children |
| title_full | Comparative efficacy of chloroquine and pyrimethamine-sulfadoxine versus artemether and pyrimethamine-sulfadoxine in the treatment of uncomplicated falciparum malaria in children |
| title_fullStr | Comparative efficacy of chloroquine and pyrimethamine-sulfadoxine versus artemether and pyrimethamine-sulfadoxine in the treatment of uncomplicated falciparum malaria in children |
| title_full_unstemmed | Comparative efficacy of chloroquine and pyrimethamine-sulfadoxine versus artemether and pyrimethamine-sulfadoxine in the treatment of uncomplicated falciparum malaria in children |
| title_short | Comparative efficacy of chloroquine and pyrimethamine-sulfadoxine versus artemether and pyrimethamine-sulfadoxine in the treatment of uncomplicated falciparum malaria in children |
| title_sort | comparative efficacy of chloroquine and pyrimethamine sulfadoxine versus artemether and pyrimethamine sulfadoxine in the treatment of uncomplicated falciparum malaria in children |
| topic | chloroquine pyrimethamine-sulfadoxine artemether fever clearance time parasite clearance time falciparum malaria |
| url | https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/783 |
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