Short-Term Fasting Synergizes with Solid Cancer Therapy by Boosting Antitumor Immunity
Short-term fasting (STF), using a low caloric, low protein fasting mimicking diet (FMD), appears to be a promising strategy to enhance chemotherapy-based cancer efficacy, while potentially alleviating toxicity. Preclinical results suggest that enhanced tumor immunity and decreased growth signaling,...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-03-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/14/6/1390 |
| _version_ | 1797472519937064960 |
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| author | Nadia de Gruil Hanno Pijl Sjoerd H. van der Burg Judith R. Kroep |
| author_facet | Nadia de Gruil Hanno Pijl Sjoerd H. van der Burg Judith R. Kroep |
| author_sort | Nadia de Gruil |
| collection | DOAJ |
| description | Short-term fasting (STF), using a low caloric, low protein fasting mimicking diet (FMD), appears to be a promising strategy to enhance chemotherapy-based cancer efficacy, while potentially alleviating toxicity. Preclinical results suggest that enhanced tumor immunity and decreased growth signaling, via lowering of circulating insulin and insulin growth factor 1 (IGF-1) levels form the potential underlying mechanisms. STF may boost anti-tumor responses by promoting tumor immunogenicity and decreasing local immunosuppression. These findings warrant further studies focused on the combination of STF, not only with chemotherapy, but also with immunotherapy to evaluate the full range of benefits of STF in cancer treatment. Here, we delineate the underlying anticancer mechanisms of fasting. We summarize preclinical evidence of STF boosting antitumor immunity and alleviating immunosuppression, as well as the clinical findings reporting the immunomodulatory effects of STF during various cancer treatments, including immunotherapy. |
| first_indexed | 2024-03-09T20:02:53Z |
| format | Article |
| id | doaj.art-6c75e54dd05b4a548cbd8fbb2947c82c |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T20:02:53Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-6c75e54dd05b4a548cbd8fbb2947c82c2023-11-24T00:40:14ZengMDPI AGCancers2072-66942022-03-01146139010.3390/cancers14061390Short-Term Fasting Synergizes with Solid Cancer Therapy by Boosting Antitumor ImmunityNadia de Gruil0Hanno Pijl1Sjoerd H. van der Burg2Judith R. Kroep3Department of Medical Oncology, Leiden University Medical Center, 2333 ZA Leiden, The NetherlandsDivision of Endocrinology, Leiden University Medical Center, 2333 ZA Leiden, The NetherlandsDepartment of Medical Oncology, Leiden University Medical Center, 2333 ZA Leiden, The NetherlandsDepartment of Medical Oncology, Leiden University Medical Center, 2333 ZA Leiden, The NetherlandsShort-term fasting (STF), using a low caloric, low protein fasting mimicking diet (FMD), appears to be a promising strategy to enhance chemotherapy-based cancer efficacy, while potentially alleviating toxicity. Preclinical results suggest that enhanced tumor immunity and decreased growth signaling, via lowering of circulating insulin and insulin growth factor 1 (IGF-1) levels form the potential underlying mechanisms. STF may boost anti-tumor responses by promoting tumor immunogenicity and decreasing local immunosuppression. These findings warrant further studies focused on the combination of STF, not only with chemotherapy, but also with immunotherapy to evaluate the full range of benefits of STF in cancer treatment. Here, we delineate the underlying anticancer mechanisms of fasting. We summarize preclinical evidence of STF boosting antitumor immunity and alleviating immunosuppression, as well as the clinical findings reporting the immunomodulatory effects of STF during various cancer treatments, including immunotherapy.https://www.mdpi.com/2072-6694/14/6/1390short-term fastingfasting mimicking dietcancer therapyimmunomodulationcancer immunitychemotherapy |
| spellingShingle | Nadia de Gruil Hanno Pijl Sjoerd H. van der Burg Judith R. Kroep Short-Term Fasting Synergizes with Solid Cancer Therapy by Boosting Antitumor Immunity Cancers short-term fasting fasting mimicking diet cancer therapy immunomodulation cancer immunity chemotherapy |
| title | Short-Term Fasting Synergizes with Solid Cancer Therapy by Boosting Antitumor Immunity |
| title_full | Short-Term Fasting Synergizes with Solid Cancer Therapy by Boosting Antitumor Immunity |
| title_fullStr | Short-Term Fasting Synergizes with Solid Cancer Therapy by Boosting Antitumor Immunity |
| title_full_unstemmed | Short-Term Fasting Synergizes with Solid Cancer Therapy by Boosting Antitumor Immunity |
| title_short | Short-Term Fasting Synergizes with Solid Cancer Therapy by Boosting Antitumor Immunity |
| title_sort | short term fasting synergizes with solid cancer therapy by boosting antitumor immunity |
| topic | short-term fasting fasting mimicking diet cancer therapy immunomodulation cancer immunity chemotherapy |
| url | https://www.mdpi.com/2072-6694/14/6/1390 |
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