Contribution of single-nucleotide polymorphism in transcription factor 7-like 2 gene to cardiometabolic risk in adult Nigerians
Background: Single-nucleotide polymorphism in the gene, transcription factor 7-like 2 (TCF7L2), shows the strongest and most consistent association with risk of developing type 2 diabetes (T2D). TCF7L2 has been associated with both impaired beta-cell function and insulin resistance. Gene variants of...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2019-01-01
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| Series: | International Journal of Noncommunicable Diseases |
| Subjects: | |
| Online Access: | http://www.ijncd.org/article.asp?issn=2468-8827;year=2019;volume=4;issue=3;spage=80;epage=85;aulast=Udenze |
| _version_ | 1811237937667375104 |
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| author | Ifeoma Christiana Udenze Idowu A Taiwo Oyesola O Ojewunmi |
| author_facet | Ifeoma Christiana Udenze Idowu A Taiwo Oyesola O Ojewunmi |
| author_sort | Ifeoma Christiana Udenze |
| collection | DOAJ |
| description | Background: Single-nucleotide polymorphism in the gene, transcription factor 7-like 2 (TCF7L2), shows the strongest and most consistent association with risk of developing type 2 diabetes (T2D). TCF7L2 has been associated with both impaired beta-cell function and insulin resistance. Gene variants of TCF7L2 may, therefore, contribute to cardiometabolic risk (CMR) and metabolic syndrome (MS).
Aims and Objectives: The study aims to examine the relationship between gene variants in TCF7L2 with MS and CMR.
Methods: Three hundred and fifty-six adult Nigerians aged between 40 and 100 years participated in a cross-sectional, analytical study. The association between TCF7L2 genotypes and MS and its components was determined. The data were analyzed, and statistical significance was set at P< 0.05.
Results: Three hundred and fifty-six individuals participated in the study (35.6% of males and 64.2% of females). About 64.9% of participants had T2D. The prevalence of MS was 26.4%. Among the individuals with the wild-type homozygote genotype CC, heterozygote genotype CT, and homozygote mutant TT, 24.9%, 27.2%, and 30.6% had MS, respectively. The risk T allele was associated with higher mean values of waist circumference and triglyceride than the C allele (P = 0.006 and 0.022, respectively). The T allele had a significant correlation with MS components (P < 0.05). In multivariate regression analysis, quantitative index of insulin resistance (Quantitative Insulin-Sensitivity Check Index) remained independently associated with the T risk allele (P = 0.033).
Conclusion: Variants in the TCF7L2 gene are associated with components of MS and correlate with CMR through insulin resistance. |
| first_indexed | 2024-04-12T12:33:09Z |
| format | Article |
| id | doaj.art-6c7711ed5aa94c12824f91b2b5dcdd0a |
| institution | Directory Open Access Journal |
| issn | 2468-8827 2468-8835 |
| language | English |
| last_indexed | 2024-04-12T12:33:09Z |
| publishDate | 2019-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | International Journal of Noncommunicable Diseases |
| spelling | doaj.art-6c7711ed5aa94c12824f91b2b5dcdd0a2022-12-22T03:32:58ZengWolters Kluwer Medknow PublicationsInternational Journal of Noncommunicable Diseases2468-88272468-88352019-01-0143808510.4103/jncd.jncd_1_19Contribution of single-nucleotide polymorphism in transcription factor 7-like 2 gene to cardiometabolic risk in adult NigeriansIfeoma Christiana UdenzeIdowu A TaiwoOyesola O OjewunmiBackground: Single-nucleotide polymorphism in the gene, transcription factor 7-like 2 (TCF7L2), shows the strongest and most consistent association with risk of developing type 2 diabetes (T2D). TCF7L2 has been associated with both impaired beta-cell function and insulin resistance. Gene variants of TCF7L2 may, therefore, contribute to cardiometabolic risk (CMR) and metabolic syndrome (MS). Aims and Objectives: The study aims to examine the relationship between gene variants in TCF7L2 with MS and CMR. Methods: Three hundred and fifty-six adult Nigerians aged between 40 and 100 years participated in a cross-sectional, analytical study. The association between TCF7L2 genotypes and MS and its components was determined. The data were analyzed, and statistical significance was set at P< 0.05. Results: Three hundred and fifty-six individuals participated in the study (35.6% of males and 64.2% of females). About 64.9% of participants had T2D. The prevalence of MS was 26.4%. Among the individuals with the wild-type homozygote genotype CC, heterozygote genotype CT, and homozygote mutant TT, 24.9%, 27.2%, and 30.6% had MS, respectively. The risk T allele was associated with higher mean values of waist circumference and triglyceride than the C allele (P = 0.006 and 0.022, respectively). The T allele had a significant correlation with MS components (P < 0.05). In multivariate regression analysis, quantitative index of insulin resistance (Quantitative Insulin-Sensitivity Check Index) remained independently associated with the T risk allele (P = 0.033). Conclusion: Variants in the TCF7L2 gene are associated with components of MS and correlate with CMR through insulin resistance.http://www.ijncd.org/article.asp?issn=2468-8827;year=2019;volume=4;issue=3;spage=80;epage=85;aulast=UdenzeCardiometabolic riskmetabolic syndromesingle-nucleotide polymorphismtranscription factor 7-like 2type 2 diabetes |
| spellingShingle | Ifeoma Christiana Udenze Idowu A Taiwo Oyesola O Ojewunmi Contribution of single-nucleotide polymorphism in transcription factor 7-like 2 gene to cardiometabolic risk in adult Nigerians International Journal of Noncommunicable Diseases Cardiometabolic risk metabolic syndrome single-nucleotide polymorphism transcription factor 7-like 2 type 2 diabetes |
| title | Contribution of single-nucleotide polymorphism in transcription factor 7-like 2 gene to cardiometabolic risk in adult Nigerians |
| title_full | Contribution of single-nucleotide polymorphism in transcription factor 7-like 2 gene to cardiometabolic risk in adult Nigerians |
| title_fullStr | Contribution of single-nucleotide polymorphism in transcription factor 7-like 2 gene to cardiometabolic risk in adult Nigerians |
| title_full_unstemmed | Contribution of single-nucleotide polymorphism in transcription factor 7-like 2 gene to cardiometabolic risk in adult Nigerians |
| title_short | Contribution of single-nucleotide polymorphism in transcription factor 7-like 2 gene to cardiometabolic risk in adult Nigerians |
| title_sort | contribution of single nucleotide polymorphism in transcription factor 7 like 2 gene to cardiometabolic risk in adult nigerians |
| topic | Cardiometabolic risk metabolic syndrome single-nucleotide polymorphism transcription factor 7-like 2 type 2 diabetes |
| url | http://www.ijncd.org/article.asp?issn=2468-8827;year=2019;volume=4;issue=3;spage=80;epage=85;aulast=Udenze |
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