The Selective LAT1 Inhibitor JPH203 Enhances Mitochondrial Metabolism and Content in Insulin-Sensitive and Insulin-Resistant C2C12 Myotubes

The Selective LAT1 Inhibitor JPH203 Enhances Mitochondrial Metabolism and Content in Insulin-Sensitive and Insulin-Resistant C2C12 Myotubes

Population data have shown an association between higher circulating branched-chain amino acids (BCAA) and the severity of insulin resistance in people with diabetes. While several studies have assessed BCAA metabolism as a potential target for regulation, less attention has been paid to the role of...

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Bibliographic Details
Main Authors: Caroline N. Rivera, Carly E. Smith, Lillian V. Draper, Gabriela E. Ochoa, Rachel M. Watne, Andrew J. Wommack, Roger A. Vaughan
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Metabolites
Subjects:
leucine
isoleucine
valine
pAkt/Akt
skeletal muscle
insulin resistance
Online Access:https://www.mdpi.com/2218-1989/13/6/766

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