Recent Advancement in Drug Design and Discovery of Pyrazole Biomolecules as Cancer and Inflammation Therapeutics
Pyrazole, an important pharmacophore and a privileged scaffold of immense significance, is a five-membered heterocyclic moiety with an extensive therapeutic profile, viz., anti-inflammatory, anti-microbial, anti-anxiety, anticancer, analgesic, antipyretic, etc. Due to the expansion of pyrazolecent r...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-12-01
|
| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/27/24/8708 |
| _version_ | 1797456080757850112 |
|---|---|
| author | Md. Jahangir Alam Ozair Alam Mohd. Javed Naim Farah Nawaz Ajay Manaithiya Mohd Imran Hamdy Khamees Thabet Sultan Alshehri Mohammed M. Ghoneim Prawez Alam Faiyaz Shakeel |
| author_facet | Md. Jahangir Alam Ozair Alam Mohd. Javed Naim Farah Nawaz Ajay Manaithiya Mohd Imran Hamdy Khamees Thabet Sultan Alshehri Mohammed M. Ghoneim Prawez Alam Faiyaz Shakeel |
| author_sort | Md. Jahangir Alam |
| collection | DOAJ |
| description | Pyrazole, an important pharmacophore and a privileged scaffold of immense significance, is a five-membered heterocyclic moiety with an extensive therapeutic profile, viz., anti-inflammatory, anti-microbial, anti-anxiety, anticancer, analgesic, antipyretic, etc. Due to the expansion of pyrazolecent red pharmacological molecules at a quicker pace, there is an urgent need to put emphasis on recent literature with hitherto available information to recognize the status of this scaffold for pharmaceutical research. The reported potential pyrazole-containing compounds are highlighted in the manuscript for the treatment of cancer and inflammation, and the results are mentioned in % inhibition of inflammation, % growth inhibition, IC<sub>50</sub>, etc. Pyrazole is an important heterocyclic moiety with a strong pharmacological profile, which may act as an important pharmacophore for the drug discovery process. In the struggle to cultivate suitable anti-inflammatory and anticancer agents, chemists have now focused on pyrazole biomolecules. This review conceals the recent expansion of pyrazole biomolecules as anti-inflammatory and anticancer agents with an aim to provide better correlation among different research going around the world. |
| first_indexed | 2024-03-09T16:03:16Z |
| format | Article |
| id | doaj.art-6c78b83607334a1291573b824dfbe948 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T16:03:16Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-6c78b83607334a1291573b824dfbe9482023-11-24T16:56:03ZengMDPI AGMolecules1420-30492022-12-012724870810.3390/molecules27248708Recent Advancement in Drug Design and Discovery of Pyrazole Biomolecules as Cancer and Inflammation TherapeuticsMd. Jahangir Alam0Ozair Alam1Mohd. Javed Naim2Farah Nawaz3Ajay Manaithiya4Mohd Imran5Hamdy Khamees Thabet6Sultan Alshehri7Mohammed M. Ghoneim8Prawez Alam9Faiyaz Shakeel10Medicinal Chemistry and Molecular Modelling Lab, Department of Pharmaceutical Chemistry, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi 110062, IndiaMedicinal Chemistry and Molecular Modelling Lab, Department of Pharmaceutical Chemistry, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi 110062, IndiaDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Tishk International University, Erbil 44001, Kurdistan Region, IraqMedicinal Chemistry and Molecular Modelling Lab, Department of Pharmaceutical Chemistry, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi 110062, IndiaMedicinal Chemistry and Molecular Modelling Lab, Department of Pharmaceutical Chemistry, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi 110062, IndiaDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Northern Border University, Rafha 91911, Saudi ArabiaDepartment of Chemistry, Faculty of Arts and Sciences, Northern Border University, Rafha 91911, Saudi ArabiaDepartment of Pharmaceutical Sciences, College of Pharmacy, AlMaarefa University, Ad Diriyah 13713, Saudi ArabiaDepartment of Pharmacy Practice, College of Pharmacy, AlMaarefa University, Ad Diriyah 13713, Saudi ArabiaDepartment of Pharmacognosy, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-Kharj 11942, Saudi ArabiaDepartment of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh 11451, Saudi ArabiaPyrazole, an important pharmacophore and a privileged scaffold of immense significance, is a five-membered heterocyclic moiety with an extensive therapeutic profile, viz., anti-inflammatory, anti-microbial, anti-anxiety, anticancer, analgesic, antipyretic, etc. Due to the expansion of pyrazolecent red pharmacological molecules at a quicker pace, there is an urgent need to put emphasis on recent literature with hitherto available information to recognize the status of this scaffold for pharmaceutical research. The reported potential pyrazole-containing compounds are highlighted in the manuscript for the treatment of cancer and inflammation, and the results are mentioned in % inhibition of inflammation, % growth inhibition, IC<sub>50</sub>, etc. Pyrazole is an important heterocyclic moiety with a strong pharmacological profile, which may act as an important pharmacophore for the drug discovery process. In the struggle to cultivate suitable anti-inflammatory and anticancer agents, chemists have now focused on pyrazole biomolecules. This review conceals the recent expansion of pyrazole biomolecules as anti-inflammatory and anticancer agents with an aim to provide better correlation among different research going around the world.https://www.mdpi.com/1420-3049/27/24/8708pyrazolebiomoleculesanticanceranti-inflammatory |
| spellingShingle | Md. Jahangir Alam Ozair Alam Mohd. Javed Naim Farah Nawaz Ajay Manaithiya Mohd Imran Hamdy Khamees Thabet Sultan Alshehri Mohammed M. Ghoneim Prawez Alam Faiyaz Shakeel Recent Advancement in Drug Design and Discovery of Pyrazole Biomolecules as Cancer and Inflammation Therapeutics Molecules pyrazole biomolecules anticancer anti-inflammatory |
| title | Recent Advancement in Drug Design and Discovery of Pyrazole Biomolecules as Cancer and Inflammation Therapeutics |
| title_full | Recent Advancement in Drug Design and Discovery of Pyrazole Biomolecules as Cancer and Inflammation Therapeutics |
| title_fullStr | Recent Advancement in Drug Design and Discovery of Pyrazole Biomolecules as Cancer and Inflammation Therapeutics |
| title_full_unstemmed | Recent Advancement in Drug Design and Discovery of Pyrazole Biomolecules as Cancer and Inflammation Therapeutics |
| title_short | Recent Advancement in Drug Design and Discovery of Pyrazole Biomolecules as Cancer and Inflammation Therapeutics |
| title_sort | recent advancement in drug design and discovery of pyrazole biomolecules as cancer and inflammation therapeutics |
| topic | pyrazole biomolecules anticancer anti-inflammatory |
| url | https://www.mdpi.com/1420-3049/27/24/8708 |
| work_keys_str_mv | AT mdjahangiralam recentadvancementindrugdesignanddiscoveryofpyrazolebiomoleculesascancerandinflammationtherapeutics AT ozairalam recentadvancementindrugdesignanddiscoveryofpyrazolebiomoleculesascancerandinflammationtherapeutics AT mohdjavednaim recentadvancementindrugdesignanddiscoveryofpyrazolebiomoleculesascancerandinflammationtherapeutics AT farahnawaz recentadvancementindrugdesignanddiscoveryofpyrazolebiomoleculesascancerandinflammationtherapeutics AT ajaymanaithiya recentadvancementindrugdesignanddiscoveryofpyrazolebiomoleculesascancerandinflammationtherapeutics AT mohdimran recentadvancementindrugdesignanddiscoveryofpyrazolebiomoleculesascancerandinflammationtherapeutics AT hamdykhameesthabet recentadvancementindrugdesignanddiscoveryofpyrazolebiomoleculesascancerandinflammationtherapeutics AT sultanalshehri recentadvancementindrugdesignanddiscoveryofpyrazolebiomoleculesascancerandinflammationtherapeutics AT mohammedmghoneim recentadvancementindrugdesignanddiscoveryofpyrazolebiomoleculesascancerandinflammationtherapeutics AT prawezalam recentadvancementindrugdesignanddiscoveryofpyrazolebiomoleculesascancerandinflammationtherapeutics AT faiyazshakeel recentadvancementindrugdesignanddiscoveryofpyrazolebiomoleculesascancerandinflammationtherapeutics |