Novel strategies to reverse chemoresistance in colorectal cancer
Abstract Colorectal cancer (CRC) is a common gastrointestinal malignancy with high morbidity and fatality. Chemotherapy, as traditional therapy for CRC, has exerted well antitumor effect and greatly improved the survival of CRC patients. Nevertheless, chemoresistance is one of the major problems dur...
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Format: | Article |
Language: | English |
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Wiley
2023-05-01
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Series: | Cancer Medicine |
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Online Access: | https://doi.org/10.1002/cam4.5594 |
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author | Shu‐Chang Ma Jia‐Qi Zhang Tian‐Hua Yan Ming‐Xing Miao Ye‐Min Cao Yong‐Bing Cao Li‐Chao Zhang Ling Li |
author_facet | Shu‐Chang Ma Jia‐Qi Zhang Tian‐Hua Yan Ming‐Xing Miao Ye‐Min Cao Yong‐Bing Cao Li‐Chao Zhang Ling Li |
author_sort | Shu‐Chang Ma |
collection | DOAJ |
description | Abstract Colorectal cancer (CRC) is a common gastrointestinal malignancy with high morbidity and fatality. Chemotherapy, as traditional therapy for CRC, has exerted well antitumor effect and greatly improved the survival of CRC patients. Nevertheless, chemoresistance is one of the major problems during chemotherapy for CRC and significantly limits the efficacy of the treatment and influences the prognosis of patients. To overcome chemoresistance in CRC, many strategies are being investigated. Here, we review the common and novel measures to combat the resistance, including drug repurposing (nonsteroidal anti‐inflammatory drugs, metformin, dichloroacetate, enalapril, ivermectin, bazedoxifene, melatonin, and S‐adenosylmethionine), gene therapy (ribozymes, RNAi, CRISPR/Cas9, epigenetic therapy, antisense oligonucleotides, and noncoding RNAs), protein inhibitor (EFGR inhibitor, S1PR2 inhibitor, and DNA methyltransferase inhibitor), natural herbal compounds (polyphenols, terpenoids, quinones, alkaloids, and sterols), new drug delivery system (nanocarriers, liposomes, exosomes, and hydrogels), and combination therapy. These common or novel strategies for the reversal of chemoresistance promise to improve the treatment of CRC. |
first_indexed | 2024-03-13T07:07:36Z |
format | Article |
id | doaj.art-6c78f327e58c46d6a5153cbb473f0de7 |
institution | Directory Open Access Journal |
issn | 2045-7634 |
language | English |
last_indexed | 2024-03-13T07:07:36Z |
publishDate | 2023-05-01 |
publisher | Wiley |
record_format | Article |
series | Cancer Medicine |
spelling | doaj.art-6c78f327e58c46d6a5153cbb473f0de72023-06-06T07:30:47ZengWileyCancer Medicine2045-76342023-05-011210110731109610.1002/cam4.5594Novel strategies to reverse chemoresistance in colorectal cancerShu‐Chang Ma0Jia‐Qi Zhang1Tian‐Hua Yan2Ming‐Xing Miao3Ye‐Min Cao4Yong‐Bing Cao5Li‐Chao Zhang6Ling Li7Institute of Vascular Disease, Shanghai TCM‐Integrated Hospital Shanghai University of Traditional Chinese Medicine Shanghai ChinaInstitute of Vascular Disease, Shanghai TCM‐Integrated Hospital Shanghai University of Traditional Chinese Medicine Shanghai ChinaDepartment of Physiology and Pharmacology China Pharmaceutic University Nanjing ChinaDepartment of Physiology and Pharmacology China Pharmaceutic University Nanjing ChinaInstitute of Vascular Disease, Shanghai TCM‐Integrated Hospital Shanghai University of Traditional Chinese Medicine Shanghai ChinaInstitute of Vascular Disease, Shanghai TCM‐Integrated Hospital Shanghai University of Traditional Chinese Medicine Shanghai ChinaDepartment of Pharmacy Shanghai Municipal Hospital of Traditional Chinese Medicine Shanghai ChinaInstitute of Vascular Disease, Shanghai TCM‐Integrated Hospital Shanghai University of Traditional Chinese Medicine Shanghai ChinaAbstract Colorectal cancer (CRC) is a common gastrointestinal malignancy with high morbidity and fatality. Chemotherapy, as traditional therapy for CRC, has exerted well antitumor effect and greatly improved the survival of CRC patients. Nevertheless, chemoresistance is one of the major problems during chemotherapy for CRC and significantly limits the efficacy of the treatment and influences the prognosis of patients. To overcome chemoresistance in CRC, many strategies are being investigated. Here, we review the common and novel measures to combat the resistance, including drug repurposing (nonsteroidal anti‐inflammatory drugs, metformin, dichloroacetate, enalapril, ivermectin, bazedoxifene, melatonin, and S‐adenosylmethionine), gene therapy (ribozymes, RNAi, CRISPR/Cas9, epigenetic therapy, antisense oligonucleotides, and noncoding RNAs), protein inhibitor (EFGR inhibitor, S1PR2 inhibitor, and DNA methyltransferase inhibitor), natural herbal compounds (polyphenols, terpenoids, quinones, alkaloids, and sterols), new drug delivery system (nanocarriers, liposomes, exosomes, and hydrogels), and combination therapy. These common or novel strategies for the reversal of chemoresistance promise to improve the treatment of CRC.https://doi.org/10.1002/cam4.5594chemoresistancecolorectal cancernovel strategiesreversal of resistance |
spellingShingle | Shu‐Chang Ma Jia‐Qi Zhang Tian‐Hua Yan Ming‐Xing Miao Ye‐Min Cao Yong‐Bing Cao Li‐Chao Zhang Ling Li Novel strategies to reverse chemoresistance in colorectal cancer Cancer Medicine chemoresistance colorectal cancer novel strategies reversal of resistance |
title | Novel strategies to reverse chemoresistance in colorectal cancer |
title_full | Novel strategies to reverse chemoresistance in colorectal cancer |
title_fullStr | Novel strategies to reverse chemoresistance in colorectal cancer |
title_full_unstemmed | Novel strategies to reverse chemoresistance in colorectal cancer |
title_short | Novel strategies to reverse chemoresistance in colorectal cancer |
title_sort | novel strategies to reverse chemoresistance in colorectal cancer |
topic | chemoresistance colorectal cancer novel strategies reversal of resistance |
url | https://doi.org/10.1002/cam4.5594 |
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