Enzyme-Site Blocking Combined with Optimization of Molecular Docking for Efficient Discovery of Potential Tyrosinase Specific Inhibitors from Puerariae lobatae Radix

Enzyme-Site Blocking Combined with Optimization of Molecular Docking for Efficient Discovery of Potential Tyrosinase Specific Inhibitors from Puerariae lobatae Radix

Enzyme inhibitors from natural products are becoming an attractive target for drug discovery and development; however, separating enzyme inhibitors from natural-product extracts is highly complex. In this study, we developed a strategy based on tyrosinase-site blocking ultrafiltration integrated wit...

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Bibliographic Details
Main Authors: Haichun Liu, Yitian Zhu, Ting Wang, Jin Qi, Xuming Liu
Format: Article
Language:English
Published: MDPI AG 2018-10-01
Series:Molecules
Subjects:
affinity-ultrafiltration-MS
molecular docking
tyrosinase inhibitors
Online Access:http://www.mdpi.com/1420-3049/23/10/2612

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