BXD Recombinant Inbred Mice as a Model to Study Neurotoxicity
BXD recombinant inbred (RI) lines represent a genetic reference population derived from a cross between C57BL/6J mice (B6) and DBA/2J mice (D2), which through meiotic recombination events possesses recombinant chromosomes containing B6 or D2 haplotype segments. The quantitative trait loci (QTLs) are...
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| Format: | Article |
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MDPI AG
2021-11-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/11/12/1762 |
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| author | Airton C. Martins Caridad López-Granero Beatriz Ferrer Alexey A. Tinkov Anatoly V. Skalny Monica M. B. Paoliello Michael Aschner |
| author_facet | Airton C. Martins Caridad López-Granero Beatriz Ferrer Alexey A. Tinkov Anatoly V. Skalny Monica M. B. Paoliello Michael Aschner |
| author_sort | Airton C. Martins |
| collection | DOAJ |
| description | BXD recombinant inbred (RI) lines represent a genetic reference population derived from a cross between C57BL/6J mice (B6) and DBA/2J mice (D2), which through meiotic recombination events possesses recombinant chromosomes containing B6 or D2 haplotype segments. The quantitative trait loci (QTLs) are the locations of segregating genetic polymorphisms and are fundamental to understanding genetic diversity in human disease susceptibility and severity. QTL mapping represents the typical approach for identifying naturally occurring polymorphisms that influence complex phenotypes. In this process, genotypic values at markers of known genomic locations are associated with phenotypic values measured in a segregating population. Indeed, BXD RI strains provide a powerful tool to study neurotoxicity induced by different substances. In this review, we describe the use of BXD RI lines to understand the underlying mechanisms of neurotoxicity in response to ethanol and cocaine, as well as metals and pesticide exposures. |
| first_indexed | 2024-03-10T04:33:44Z |
| format | Article |
| id | doaj.art-6c7a280932f347caab1b346ccd6c8094 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-10T04:33:44Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-6c7a280932f347caab1b346ccd6c80942023-11-23T03:58:45ZengMDPI AGBiomolecules2218-273X2021-11-011112176210.3390/biom11121762BXD Recombinant Inbred Mice as a Model to Study NeurotoxicityAirton C. Martins0Caridad López-Granero1Beatriz Ferrer2Alexey A. Tinkov3Anatoly V. Skalny4Monica M. B. Paoliello5Michael Aschner6Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USADepartamento de Psicología y Sociología, Campus Ciudad Escolar, Universidad de Zaragoza, 44003 Teruel, SpainDepartment of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USALaboratory of Molecular Dietetics, IM Sechenov First Moscow State Medical University, 119435 Moscow, RussiaWorld-Class Research Center “Digital Biodesign and Personalized Healthcare”, IM Sechenov First Moscow State Medical University (Sechenov University), 119435 Moscow, RussiaDepartment of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USADepartment of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USABXD recombinant inbred (RI) lines represent a genetic reference population derived from a cross between C57BL/6J mice (B6) and DBA/2J mice (D2), which through meiotic recombination events possesses recombinant chromosomes containing B6 or D2 haplotype segments. The quantitative trait loci (QTLs) are the locations of segregating genetic polymorphisms and are fundamental to understanding genetic diversity in human disease susceptibility and severity. QTL mapping represents the typical approach for identifying naturally occurring polymorphisms that influence complex phenotypes. In this process, genotypic values at markers of known genomic locations are associated with phenotypic values measured in a segregating population. Indeed, BXD RI strains provide a powerful tool to study neurotoxicity induced by different substances. In this review, we describe the use of BXD RI lines to understand the underlying mechanisms of neurotoxicity in response to ethanol and cocaine, as well as metals and pesticide exposures.https://www.mdpi.com/2218-273X/11/12/1762geneticalcoholmetalscocainepesticides |
| spellingShingle | Airton C. Martins Caridad López-Granero Beatriz Ferrer Alexey A. Tinkov Anatoly V. Skalny Monica M. B. Paoliello Michael Aschner BXD Recombinant Inbred Mice as a Model to Study Neurotoxicity Biomolecules genetic alcohol metals cocaine pesticides |
| title | BXD Recombinant Inbred Mice as a Model to Study Neurotoxicity |
| title_full | BXD Recombinant Inbred Mice as a Model to Study Neurotoxicity |
| title_fullStr | BXD Recombinant Inbred Mice as a Model to Study Neurotoxicity |
| title_full_unstemmed | BXD Recombinant Inbred Mice as a Model to Study Neurotoxicity |
| title_short | BXD Recombinant Inbred Mice as a Model to Study Neurotoxicity |
| title_sort | bxd recombinant inbred mice as a model to study neurotoxicity |
| topic | genetic alcohol metals cocaine pesticides |
| url | https://www.mdpi.com/2218-273X/11/12/1762 |
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