Lipid Nanoparticle (LNP) Delivery Carrier-Assisted Targeted Controlled Release mRNA Vaccines in Tumor Immunity
In recent years, lipid nanoparticles (LNPs) have attracted extensive attention in tumor immunotherapy. Targeting immune cells in cancer therapy has become a strategy of great research interest. mRNA vaccines are a potential choice for tumor immunotherapy, due to their ability to directly encode anti...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-02-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/12/2/186 |
| _version_ | 1797296871200260096 |
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| author | Liusheng Wu Xiaoqiang Li Xinye Qian Shuang Wang Jixian Liu Jun Yan |
| author_facet | Liusheng Wu Xiaoqiang Li Xinye Qian Shuang Wang Jixian Liu Jun Yan |
| author_sort | Liusheng Wu |
| collection | DOAJ |
| description | In recent years, lipid nanoparticles (LNPs) have attracted extensive attention in tumor immunotherapy. Targeting immune cells in cancer therapy has become a strategy of great research interest. mRNA vaccines are a potential choice for tumor immunotherapy, due to their ability to directly encode antigen proteins and stimulate a strong immune response. However, the mode of delivery and lack of stability of mRNA are key issues limiting its application. LNPs are an excellent mRNA delivery carrier, and their structural stability and biocompatibility make them an effective means for delivering mRNA to specific targets. This study summarizes the research progress in LNP delivery carrier-assisted targeted controlled release mRNA vaccines in tumor immunity. The role of LNPs in improving mRNA stability, immunogenicity, and targeting is discussed. This review aims to systematically summarize the latest research progress in LNP delivery carrier-assisted targeted controlled release mRNA vaccines in tumor immunity to provide new ideas and strategies for tumor immunotherapy, as well as to provide more effective treatment plans for patients. |
| first_indexed | 2024-03-07T22:11:04Z |
| format | Article |
| id | doaj.art-6c7a3bc40bc84fd8b9c4e58ac7414364 |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-07T22:11:04Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-6c7a3bc40bc84fd8b9c4e58ac74143642024-02-23T15:37:07ZengMDPI AGVaccines2076-393X2024-02-0112218610.3390/vaccines12020186Lipid Nanoparticle (LNP) Delivery Carrier-Assisted Targeted Controlled Release mRNA Vaccines in Tumor ImmunityLiusheng Wu0Xiaoqiang Li1Xinye Qian2Shuang Wang3Jixian Liu4Jun Yan5Center of Hepatobiliary Pancreatic Disease, Beijing Tsinghua Changgung Hospital, School of Medicine, Tsinghua University, Beijing 100084, ChinaDepartment of Thoracic Surgery, Peking University Shenzhen Hospital, Shenzhen 518036, ChinaCenter of Hepatobiliary Pancreatic Disease, Beijing Tsinghua Changgung Hospital, School of Medicine, Tsinghua University, Beijing 100084, ChinaCenter of Hepatobiliary Pancreatic Disease, Beijing Tsinghua Changgung Hospital, School of Medicine, Tsinghua University, Beijing 100084, ChinaDepartment of Thoracic Surgery, Peking University Shenzhen Hospital, Shenzhen 518036, ChinaCenter of Hepatobiliary Pancreatic Disease, Beijing Tsinghua Changgung Hospital, School of Medicine, Tsinghua University, Beijing 100084, ChinaIn recent years, lipid nanoparticles (LNPs) have attracted extensive attention in tumor immunotherapy. Targeting immune cells in cancer therapy has become a strategy of great research interest. mRNA vaccines are a potential choice for tumor immunotherapy, due to their ability to directly encode antigen proteins and stimulate a strong immune response. However, the mode of delivery and lack of stability of mRNA are key issues limiting its application. LNPs are an excellent mRNA delivery carrier, and their structural stability and biocompatibility make them an effective means for delivering mRNA to specific targets. This study summarizes the research progress in LNP delivery carrier-assisted targeted controlled release mRNA vaccines in tumor immunity. The role of LNPs in improving mRNA stability, immunogenicity, and targeting is discussed. This review aims to systematically summarize the latest research progress in LNP delivery carrier-assisted targeted controlled release mRNA vaccines in tumor immunity to provide new ideas and strategies for tumor immunotherapy, as well as to provide more effective treatment plans for patients.https://www.mdpi.com/2076-393X/12/2/186lipid nanoparticles (LNPs)mRNA vaccinetumor immunitydelivery carrierreview |
| spellingShingle | Liusheng Wu Xiaoqiang Li Xinye Qian Shuang Wang Jixian Liu Jun Yan Lipid Nanoparticle (LNP) Delivery Carrier-Assisted Targeted Controlled Release mRNA Vaccines in Tumor Immunity Vaccines lipid nanoparticles (LNPs) mRNA vaccine tumor immunity delivery carrier review |
| title | Lipid Nanoparticle (LNP) Delivery Carrier-Assisted Targeted Controlled Release mRNA Vaccines in Tumor Immunity |
| title_full | Lipid Nanoparticle (LNP) Delivery Carrier-Assisted Targeted Controlled Release mRNA Vaccines in Tumor Immunity |
| title_fullStr | Lipid Nanoparticle (LNP) Delivery Carrier-Assisted Targeted Controlled Release mRNA Vaccines in Tumor Immunity |
| title_full_unstemmed | Lipid Nanoparticle (LNP) Delivery Carrier-Assisted Targeted Controlled Release mRNA Vaccines in Tumor Immunity |
| title_short | Lipid Nanoparticle (LNP) Delivery Carrier-Assisted Targeted Controlled Release mRNA Vaccines in Tumor Immunity |
| title_sort | lipid nanoparticle lnp delivery carrier assisted targeted controlled release mrna vaccines in tumor immunity |
| topic | lipid nanoparticles (LNPs) mRNA vaccine tumor immunity delivery carrier review |
| url | https://www.mdpi.com/2076-393X/12/2/186 |
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