Human mesenchymal stem cells improve rat islet functionality under cytokine stress with combined upregulation of heme oxygenase-1 and ferritin

Human mesenchymal stem cells improve rat islet functionality under cytokine stress with combined upregulation of heme oxygenase-1 and ferritin

Abstract Background Islets of Langerhans transplantation is a promising therapy for type 1 diabetes mellitus, but this technique is compromised by transplantation stresses including inflammation. In other tissues, co-transplantation with mesenchymal stem cells has been shown to reduce damage by impr...

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Main Authors: Camille Laporte, Emily Tubbs, Justine Cristante, Anne-Sophie Gauchez, Sandra Pesenti, Frédéric Lamarche, Cécile Cottet-Rousselle, Catherine Garrel, Anaick Moisan, Jean-Marc Moulis, Eric Fontaine, Pierre-Yves Benhamou, Sandrine Lablanche
Format: Article
Language:English
Published: BMC 2019-03-01
Series:Stem Cell Research & Therapy
Subjects:
Diabetes mellitus type 1
Islets of Langerhans transplantation
Mesenchymal stem cells
Co-culture
Cytokines
Heme oxygenase 1
Online Access:http://link.springer.com/article/10.1186/s13287-019-1190-4

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