Adaptogenic Properties of a Phytoecdysteroid-Rich Extract from the Leaves of <i>Spinacia oleracea</i> L.
Increasing the ability of the human body to adapt in conditions of physical or emotional stress is promising from the standpoint of the use of preventive nutrition containing functional food ingredients (FFI) with proven effectiveness in complex physiological in vivo studies. In this work, we develo...
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| Format: | Article |
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MDPI AG
2021-11-01
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| Series: | Plants |
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| Online Access: | https://www.mdpi.com/2223-7747/10/12/2555 |
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| author | Yuliya S. Sidorova Vladimir A. Shipelin Nikita A. Petrov Sergey N. Zorin Vladimir K. Mazo |
| author_facet | Yuliya S. Sidorova Vladimir A. Shipelin Nikita A. Petrov Sergey N. Zorin Vladimir K. Mazo |
| author_sort | Yuliya S. Sidorova |
| collection | DOAJ |
| description | Increasing the ability of the human body to adapt in conditions of physical or emotional stress is promising from the standpoint of the use of preventive nutrition containing functional food ingredients (FFI) with proven effectiveness in complex physiological in vivo studies. In this work, we developed FFI from spinach leaves (<i>Spinacia oleracea</i> L.) with a high content of polyphenols and adaptogens—phytoecdysteroids. Using in vivo models of increased physical activity and immobilization-induced emotional stress, we evaluated the nonspecific resistance of rats in response to the addition of the developed FFI to the diet. In the acute toxicity experiment, we found no signs of FFI toxicity up to 5000 mg/kg body weight. As a result of the daily 26-day consumption of FFI, we observed an anxiolytic effect in physiological studies. FFI prevented an increase in the content of biogenic amines in the blood, the main markers of the stress system, and had a positive effect on the lipid metabolism of the rats. The obtained results demonstrate a “smoothing” effect on the body’s reaction in response to induced stress conditions. |
| first_indexed | 2024-03-10T03:17:30Z |
| format | Article |
| id | doaj.art-6c7ce42c98b642f7ba011d8a19b394bc |
| institution | Directory Open Access Journal |
| issn | 2223-7747 |
| language | English |
| last_indexed | 2024-03-10T03:17:30Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Plants |
| spelling | doaj.art-6c7ce42c98b642f7ba011d8a19b394bc2023-11-23T10:09:54ZengMDPI AGPlants2223-77472021-11-011012255510.3390/plants10122555Adaptogenic Properties of a Phytoecdysteroid-Rich Extract from the Leaves of <i>Spinacia oleracea</i> L.Yuliya S. Sidorova0Vladimir A. Shipelin1Nikita A. Petrov2Sergey N. Zorin3Vladimir K. Mazo4Federal Research Centre of Nutrition and Biotechnology, 109240 Moscow, RussiaFederal Research Centre of Nutrition and Biotechnology, 109240 Moscow, RussiaFederal Research Centre of Nutrition and Biotechnology, 109240 Moscow, RussiaFederal Research Centre of Nutrition and Biotechnology, 109240 Moscow, RussiaFederal Research Centre of Nutrition and Biotechnology, 109240 Moscow, RussiaIncreasing the ability of the human body to adapt in conditions of physical or emotional stress is promising from the standpoint of the use of preventive nutrition containing functional food ingredients (FFI) with proven effectiveness in complex physiological in vivo studies. In this work, we developed FFI from spinach leaves (<i>Spinacia oleracea</i> L.) with a high content of polyphenols and adaptogens—phytoecdysteroids. Using in vivo models of increased physical activity and immobilization-induced emotional stress, we evaluated the nonspecific resistance of rats in response to the addition of the developed FFI to the diet. In the acute toxicity experiment, we found no signs of FFI toxicity up to 5000 mg/kg body weight. As a result of the daily 26-day consumption of FFI, we observed an anxiolytic effect in physiological studies. FFI prevented an increase in the content of biogenic amines in the blood, the main markers of the stress system, and had a positive effect on the lipid metabolism of the rats. The obtained results demonstrate a “smoothing” effect on the body’s reaction in response to induced stress conditions.https://www.mdpi.com/2223-7747/10/12/2555stresspolyphenolsWistar ratsICR miceexercise testimmobilization |
| spellingShingle | Yuliya S. Sidorova Vladimir A. Shipelin Nikita A. Petrov Sergey N. Zorin Vladimir K. Mazo Adaptogenic Properties of a Phytoecdysteroid-Rich Extract from the Leaves of <i>Spinacia oleracea</i> L. Plants stress polyphenols Wistar rats ICR mice exercise test immobilization |
| title | Adaptogenic Properties of a Phytoecdysteroid-Rich Extract from the Leaves of <i>Spinacia oleracea</i> L. |
| title_full | Adaptogenic Properties of a Phytoecdysteroid-Rich Extract from the Leaves of <i>Spinacia oleracea</i> L. |
| title_fullStr | Adaptogenic Properties of a Phytoecdysteroid-Rich Extract from the Leaves of <i>Spinacia oleracea</i> L. |
| title_full_unstemmed | Adaptogenic Properties of a Phytoecdysteroid-Rich Extract from the Leaves of <i>Spinacia oleracea</i> L. |
| title_short | Adaptogenic Properties of a Phytoecdysteroid-Rich Extract from the Leaves of <i>Spinacia oleracea</i> L. |
| title_sort | adaptogenic properties of a phytoecdysteroid rich extract from the leaves of i spinacia oleracea i l |
| topic | stress polyphenols Wistar rats ICR mice exercise test immobilization |
| url | https://www.mdpi.com/2223-7747/10/12/2555 |
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