Influence of the lung microbiome on antibiotic susceptibility of cystic fibrosis pathogens
The lungs of patients with cystic fibrosis (CF) are colonised by a microbial community comprised of pathogenic species, such as Pseudomonas aeruginosa and Staphylococcus aureus, and microorganisms that are typically not associated with worse clinical outcomes (considered as commensals). Antibiotics...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
European Respiratory Society
2019-07-01
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| Series: | European Respiratory Review |
| Online Access: | http://err.ersjournals.com/content/28/152/190041.full |
| _version_ | 1818468810161651712 |
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| author | Eva Vandeplassche Sarah Tavernier Tom Coenye Aurélie Crabbé |
| author_facet | Eva Vandeplassche Sarah Tavernier Tom Coenye Aurélie Crabbé |
| author_sort | Eva Vandeplassche |
| collection | DOAJ |
| description | The lungs of patients with cystic fibrosis (CF) are colonised by a microbial community comprised of pathogenic species, such as Pseudomonas aeruginosa and Staphylococcus aureus, and microorganisms that are typically not associated with worse clinical outcomes (considered as commensals). Antibiotics directed at CF pathogens are often not effective and a discrepancy is observed between activity of these agents in vitro and in the patient. This review describes how interspecies interactions within the lung microbiome might influence the outcome of antibiotic treatment targeted at common CF pathogens. Protective mechanisms by members of the microbiome such as antibiotic degradation (indirect pathogenicity), alterations of the cell wall, production of matrix components decreasing antibiotic penetration, and changes in metabolism are discussed. Interspecies interactions that increase bacterial susceptibility are also addressed. Furthermore, we discuss how experimental conditions, such as culture media, oxygen levels, incorporation of host–pathogen interactions, and microbial community composition may influence the outcome of microbial interaction studies related to antibiotic activity. Hereby, the importance to create in vitro conditions reflective of the CF lung microenvironment is highlighted. Understanding the role of the CF lung microbiome in antibiotic efficacy may help find novel therapeutic and diagnostic approaches to better tackle chronic lung infections in this patient population. |
| first_indexed | 2024-04-13T21:15:58Z |
| format | Article |
| id | doaj.art-6c7e3b1b72884fccbdeaf1aa0a4406b6 |
| institution | Directory Open Access Journal |
| issn | 0905-9180 1600-0617 |
| language | English |
| last_indexed | 2024-04-13T21:15:58Z |
| publishDate | 2019-07-01 |
| publisher | European Respiratory Society |
| record_format | Article |
| series | European Respiratory Review |
| spelling | doaj.art-6c7e3b1b72884fccbdeaf1aa0a4406b62022-12-22T02:29:40ZengEuropean Respiratory SocietyEuropean Respiratory Review0905-91801600-06172019-07-012815210.1183/16000617.0041-20190041-2019Influence of the lung microbiome on antibiotic susceptibility of cystic fibrosis pathogensEva Vandeplassche0Sarah Tavernier1Tom Coenye2Aurélie Crabbé3 Laboratory of Pharmaceutical Microbiology, Ghent University, Ghent, Belgium Laboratory of Pharmaceutical Microbiology, Ghent University, Ghent, Belgium Laboratory of Pharmaceutical Microbiology, Ghent University, Ghent, Belgium Laboratory of Pharmaceutical Microbiology, Ghent University, Ghent, Belgium The lungs of patients with cystic fibrosis (CF) are colonised by a microbial community comprised of pathogenic species, such as Pseudomonas aeruginosa and Staphylococcus aureus, and microorganisms that are typically not associated with worse clinical outcomes (considered as commensals). Antibiotics directed at CF pathogens are often not effective and a discrepancy is observed between activity of these agents in vitro and in the patient. This review describes how interspecies interactions within the lung microbiome might influence the outcome of antibiotic treatment targeted at common CF pathogens. Protective mechanisms by members of the microbiome such as antibiotic degradation (indirect pathogenicity), alterations of the cell wall, production of matrix components decreasing antibiotic penetration, and changes in metabolism are discussed. Interspecies interactions that increase bacterial susceptibility are also addressed. Furthermore, we discuss how experimental conditions, such as culture media, oxygen levels, incorporation of host–pathogen interactions, and microbial community composition may influence the outcome of microbial interaction studies related to antibiotic activity. Hereby, the importance to create in vitro conditions reflective of the CF lung microenvironment is highlighted. Understanding the role of the CF lung microbiome in antibiotic efficacy may help find novel therapeutic and diagnostic approaches to better tackle chronic lung infections in this patient population.http://err.ersjournals.com/content/28/152/190041.full |
| spellingShingle | Eva Vandeplassche Sarah Tavernier Tom Coenye Aurélie Crabbé Influence of the lung microbiome on antibiotic susceptibility of cystic fibrosis pathogens European Respiratory Review |
| title | Influence of the lung microbiome on antibiotic susceptibility of cystic fibrosis pathogens |
| title_full | Influence of the lung microbiome on antibiotic susceptibility of cystic fibrosis pathogens |
| title_fullStr | Influence of the lung microbiome on antibiotic susceptibility of cystic fibrosis pathogens |
| title_full_unstemmed | Influence of the lung microbiome on antibiotic susceptibility of cystic fibrosis pathogens |
| title_short | Influence of the lung microbiome on antibiotic susceptibility of cystic fibrosis pathogens |
| title_sort | influence of the lung microbiome on antibiotic susceptibility of cystic fibrosis pathogens |
| url | http://err.ersjournals.com/content/28/152/190041.full |
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