CYNICAL VALUE OF SERUM INTERLEUKIN-13 LEVELS IN VINCRISTINE POLYNEUROPATHY IN CHILDREN WITH ACUTE LYMPHOBLASTIC LEUKEMIA
Summary. The leading neurotoxic complication of acute lymphoblastic leukemia treatment in children is vincristine polyneuropathy. Recent studies have demonstrated the involvement of the immune system in the pathogenetic mechanisms of peripheral nervous system damage. In recent years, there have been...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | Russian |
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St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2019-08-01
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| Series: | Медицинская иммунология |
| Subjects: | |
| Online Access: | https://www.mimmun.ru/mimmun/article/view/2865 |
| _version_ | 1797197746499747840 |
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| author | Oksana Valeryevna Koryakina Olga P. Kovtun Vladimir V. Bazarnyi Maksim A. Kopenkin |
| author_facet | Oksana Valeryevna Koryakina Olga P. Kovtun Vladimir V. Bazarnyi Maksim A. Kopenkin |
| author_sort | Oksana Valeryevna Koryakina |
| collection | DOAJ |
| description | Summary. The leading neurotoxic complication of acute lymphoblastic leukemia treatment in children is vincristine polyneuropathy. Recent studies have demonstrated the involvement of the immune system in the pathogenetic mechanisms of peripheral nervous system damage. In recent years, there have been reports examining the relationship between interleukin-13 (IL-13) and the development of toxic effects of chemotherapeutic drugs.Objective: to evaluate the clinical value of IL-13 level in children with vincristine polyneuropathy.Materials and methods: 27 children with acute lymphoblastic leukemia aged from 3 to 17 years, who received chemotherapy according to the protocol, were included in the study. Plasma IL-13 levels were determined, followed by a comparative analysis of the values in two subgroups depending on the development of vincristine polyneuropathy. IL-13 content was assessed by multiparametric immunofluorescent analysis with magnetic microspheres (xMAP technology, Luminex 200, USA) and using ProcartaPlex Human Cytokine/Chemokine test system (Invitrogen, USA).Results: in the study group of patients vincristine polyneuropathy was registered in the majority of children (n=15) with its debut mainly at the induction stage of chemotherapy and predominance of sensory disorders. In a comparative analysis of IL-13 plasma levels in patients with vincristine polyneuropathy we observed a statistically significant increase in its concentration in contrast to children without signs of peripheral nervous system damage (p=0.042). When assessing the clinical value of this index, the diagnostic sensitivity was 75%, specificity - 100%, the integral index characterizing the accuracy of the test - 0.89. IL-13 change was found to have a rather high relative risk level, indicating its significant relationship to the development of vincristine polyneuropathy.Conclusion: the results of the study on the IL-13 content in blood plasma in children with vincristine polyneuropathy allowed us to identify it as a predictor of biological marker of peripheral nervous system damage. |
| first_indexed | 2024-03-08T05:46:38Z |
| format | Article |
| id | doaj.art-6c7eddb273f246d5a98aa547a2083770 |
| institution | Directory Open Access Journal |
| issn | 1563-0625 2313-741X |
| language | Russian |
| last_indexed | 2024-04-24T06:48:52Z |
| publishDate | 2019-08-01 |
| publisher | St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists |
| record_format | Article |
| series | Медицинская иммунология |
| spelling | doaj.art-6c7eddb273f246d5a98aa547a20837702024-04-22T13:07:51ZrusSt. Petersburg branch of the Russian Association of Allergologists and Clinical ImmunologistsМедицинская иммунология1563-06252313-741X2019-08-010010.15789/1563-0625-CVO-28651816CYNICAL VALUE OF SERUM INTERLEUKIN-13 LEVELS IN VINCRISTINE POLYNEUROPATHY IN CHILDREN WITH ACUTE LYMPHOBLASTIC LEUKEMIAOksana Valeryevna Koryakina0Olga P. Kovtun1Vladimir V. Bazarnyi2Maksim A. Kopenkin3Ural State Medical University Regional Children Clinical Hospital,YekaterinburgUral State Medical UniversityUral State Medical UniversityUral State Medical UniversitySummary. The leading neurotoxic complication of acute lymphoblastic leukemia treatment in children is vincristine polyneuropathy. Recent studies have demonstrated the involvement of the immune system in the pathogenetic mechanisms of peripheral nervous system damage. In recent years, there have been reports examining the relationship between interleukin-13 (IL-13) and the development of toxic effects of chemotherapeutic drugs.Objective: to evaluate the clinical value of IL-13 level in children with vincristine polyneuropathy.Materials and methods: 27 children with acute lymphoblastic leukemia aged from 3 to 17 years, who received chemotherapy according to the protocol, were included in the study. Plasma IL-13 levels were determined, followed by a comparative analysis of the values in two subgroups depending on the development of vincristine polyneuropathy. IL-13 content was assessed by multiparametric immunofluorescent analysis with magnetic microspheres (xMAP technology, Luminex 200, USA) and using ProcartaPlex Human Cytokine/Chemokine test system (Invitrogen, USA).Results: in the study group of patients vincristine polyneuropathy was registered in the majority of children (n=15) with its debut mainly at the induction stage of chemotherapy and predominance of sensory disorders. In a comparative analysis of IL-13 plasma levels in patients with vincristine polyneuropathy we observed a statistically significant increase in its concentration in contrast to children without signs of peripheral nervous system damage (p=0.042). When assessing the clinical value of this index, the diagnostic sensitivity was 75%, specificity - 100%, the integral index characterizing the accuracy of the test - 0.89. IL-13 change was found to have a rather high relative risk level, indicating its significant relationship to the development of vincristine polyneuropathy.Conclusion: the results of the study on the IL-13 content in blood plasma in children with vincristine polyneuropathy allowed us to identify it as a predictor of biological marker of peripheral nervous system damage.https://www.mimmun.ru/mimmun/article/view/2865neurotoxicityacute leukemiachildrenpolyneuropathychemotherapyinterleukins. |
| spellingShingle | Oksana Valeryevna Koryakina Olga P. Kovtun Vladimir V. Bazarnyi Maksim A. Kopenkin CYNICAL VALUE OF SERUM INTERLEUKIN-13 LEVELS IN VINCRISTINE POLYNEUROPATHY IN CHILDREN WITH ACUTE LYMPHOBLASTIC LEUKEMIA Медицинская иммунология neurotoxicity acute leukemia children polyneuropathy chemotherapy interleukins. |
| title | CYNICAL VALUE OF SERUM INTERLEUKIN-13 LEVELS IN VINCRISTINE POLYNEUROPATHY IN CHILDREN WITH ACUTE LYMPHOBLASTIC LEUKEMIA |
| title_full | CYNICAL VALUE OF SERUM INTERLEUKIN-13 LEVELS IN VINCRISTINE POLYNEUROPATHY IN CHILDREN WITH ACUTE LYMPHOBLASTIC LEUKEMIA |
| title_fullStr | CYNICAL VALUE OF SERUM INTERLEUKIN-13 LEVELS IN VINCRISTINE POLYNEUROPATHY IN CHILDREN WITH ACUTE LYMPHOBLASTIC LEUKEMIA |
| title_full_unstemmed | CYNICAL VALUE OF SERUM INTERLEUKIN-13 LEVELS IN VINCRISTINE POLYNEUROPATHY IN CHILDREN WITH ACUTE LYMPHOBLASTIC LEUKEMIA |
| title_short | CYNICAL VALUE OF SERUM INTERLEUKIN-13 LEVELS IN VINCRISTINE POLYNEUROPATHY IN CHILDREN WITH ACUTE LYMPHOBLASTIC LEUKEMIA |
| title_sort | cynical value of serum interleukin 13 levels in vincristine polyneuropathy in children with acute lymphoblastic leukemia |
| topic | neurotoxicity acute leukemia children polyneuropathy chemotherapy interleukins. |
| url | https://www.mimmun.ru/mimmun/article/view/2865 |
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