NADPH Oxidase 5 Induces Changes in the Unfolded Protein Response in Human Aortic Endothelial Cells and in Endothelial-Specific <i>Knock-in</i> Mice

NADPH Oxidase 5 Induces Changes in the Unfolded Protein Response in Human Aortic Endothelial Cells and in Endothelial-Specific <i>Knock-in</i> Mice

Oxidative stress constitutes a key molecular mechanism in the development of cardiovascular diseases. A potential relationship between reactive oxygen species (ROS) driven by the NADPH oxidase family (NOX) and the unfolded protein response (UPR) has been postulated. Nevertheless, there is a lack of...

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Bibliographic Details
Main Authors: Adriana Cortés, Álvaro Pejenaute, Javier Marqués, Íñigo Izal, Silvia Cenoz, Eduardo Ansorena, Juan José Martínez-Irujo, Carlos de Miguel, Guillermo Zalba
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Antioxidants
Subjects:
oxidative stress
NADPH oxidase 5
unfolded protein response
chronic infarction
endothelial cells
Online Access:https://www.mdpi.com/2076-3921/10/2/194

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