From Merkel Cell Polyomavirus Infection to Merkel Cell Carcinoma Oncogenesis
Merkel cell polyomavirus (MCPyV) infection causes near-ubiquitous, asymptomatic infection in the skin, but occasionally leads to an aggressive skin cancer called Merkel cell carcinoma (MCC). Epidemiological evidence suggests that poorly controlled MCPyV infection may be a precursor to MCPyV-associat...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-09-01
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| Series: | Frontiers in Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2021.739695/full |
| _version_ | 1818738665336078336 |
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| author | Nathan A. Krump Jianxin You |
| author_facet | Nathan A. Krump Jianxin You |
| author_sort | Nathan A. Krump |
| collection | DOAJ |
| description | Merkel cell polyomavirus (MCPyV) infection causes near-ubiquitous, asymptomatic infection in the skin, but occasionally leads to an aggressive skin cancer called Merkel cell carcinoma (MCC). Epidemiological evidence suggests that poorly controlled MCPyV infection may be a precursor to MCPyV-associated MCC. Clearer understanding of host responses that normally control MCPyV infection could inform prophylactic measures in at-risk groups. Similarly, the presence of MCPyV in most MCCs could imbue them with vulnerabilities that-if better characterized-could yield targeted intervention solutions for metastatic MCC cases. In this review, we discuss recent developments in elucidating the interplay between host cells and MCPyV within the context of viral infection and MCC oncogenesis. We also propose a model in which insufficient restriction of MCPyV infection in aging and chronically UV-damaged skin causes unbridled viral replication that licenses MCC tumorigenesis. |
| first_indexed | 2024-12-18T01:12:33Z |
| format | Article |
| id | doaj.art-6c7f97ce0f0d4d519b914bddf528d916 |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-12-18T01:12:33Z |
| publishDate | 2021-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-6c7f97ce0f0d4d519b914bddf528d9162022-12-21T21:26:03ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2021-09-011210.3389/fmicb.2021.739695739695From Merkel Cell Polyomavirus Infection to Merkel Cell Carcinoma OncogenesisNathan A. KrumpJianxin YouMerkel cell polyomavirus (MCPyV) infection causes near-ubiquitous, asymptomatic infection in the skin, but occasionally leads to an aggressive skin cancer called Merkel cell carcinoma (MCC). Epidemiological evidence suggests that poorly controlled MCPyV infection may be a precursor to MCPyV-associated MCC. Clearer understanding of host responses that normally control MCPyV infection could inform prophylactic measures in at-risk groups. Similarly, the presence of MCPyV in most MCCs could imbue them with vulnerabilities that-if better characterized-could yield targeted intervention solutions for metastatic MCC cases. In this review, we discuss recent developments in elucidating the interplay between host cells and MCPyV within the context of viral infection and MCC oncogenesis. We also propose a model in which insufficient restriction of MCPyV infection in aging and chronically UV-damaged skin causes unbridled viral replication that licenses MCC tumorigenesis.https://www.frontiersin.org/articles/10.3389/fmicb.2021.739695/fullMerkel cell polyomavirusMerkel cell carcinomapersistenceinnate immune responseintegrationdysbiosis |
| spellingShingle | Nathan A. Krump Jianxin You From Merkel Cell Polyomavirus Infection to Merkel Cell Carcinoma Oncogenesis Frontiers in Microbiology Merkel cell polyomavirus Merkel cell carcinoma persistence innate immune response integration dysbiosis |
| title | From Merkel Cell Polyomavirus Infection to Merkel Cell Carcinoma Oncogenesis |
| title_full | From Merkel Cell Polyomavirus Infection to Merkel Cell Carcinoma Oncogenesis |
| title_fullStr | From Merkel Cell Polyomavirus Infection to Merkel Cell Carcinoma Oncogenesis |
| title_full_unstemmed | From Merkel Cell Polyomavirus Infection to Merkel Cell Carcinoma Oncogenesis |
| title_short | From Merkel Cell Polyomavirus Infection to Merkel Cell Carcinoma Oncogenesis |
| title_sort | from merkel cell polyomavirus infection to merkel cell carcinoma oncogenesis |
| topic | Merkel cell polyomavirus Merkel cell carcinoma persistence innate immune response integration dysbiosis |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2021.739695/full |
| work_keys_str_mv | AT nathanakrump frommerkelcellpolyomavirusinfectiontomerkelcellcarcinomaoncogenesis AT jianxinyou frommerkelcellpolyomavirusinfectiontomerkelcellcarcinomaoncogenesis |